FlyBase Allele Report: Hsap\FUS[RRMmut.UAS]

General Information

Symbol

Hsap\FUS^RRMmut.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0392838

Feature type

allele

Associated gene

Hsap\FUS

Associated Insertion(s)

Carried in Construct

P{UAS-hFUS.RRMmut}

Key Links

Transgenic product class

missense_variant

(Fujino et al., 2023)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Fujino et al., 2023)

Mutagen

in vitro construct

(Fujino et al., 2023)

Progenitor genotype

Carried in construct

P{UAS-hFUS.RRMmut}

Cytology

Description

UASt regulatory sequences drive expression of Hsap\FUS with mutations in the RNA recognition motif (RRM); leucine residues at positions 305, 341, 359, and 368 are substituted to phenylalanine.

(Fujino et al., 2023)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\FUS

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Hsap\FUS^RRMmut.UAS, Scer\GAL4^GMR.PS is a non-suppressor of partially lethal phenotype of Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS

(Fujino et al., 2023)

Hsap\FUS^RRMmut.UAS, Scer\GAL4^GMR.PS is a non-suppressor of decreased size | adult stage phenotype of Scer\GAL4^GMR.PS, Zzzz\GGGGCC^89.UAS

(Fujino et al., 2023)

Hsap\FUS^RRMmut.UAS, Scer\GAL4^GMR.PS is a non-suppressor of abnormal eye color phenotype of Scer\GAL4^GMR.PS, Zzzz\GGGGCC^89.UAS

(Fujino et al., 2023)

Hsap\FUS^RRMmut.UAS, Scer\GAL4^GMR.PS is a non-suppressor of abnormal eye color phenotype of Scer\GAL4^GMR.PS, Zzzz\poly-GR^PO-36.UAS

(Fujino et al., 2023)

Other

Statement

Reference

Hsap\FUS^RRMmut.UAS, Scer\GAL4^GMR.PS, Zzzz\poly-GR^PO-100.UAS has lethal phenotype

(Fujino et al., 2023)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Hsap\FUS^RRMmut.UAS, Scer\GAL4^GMR.PS is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS

(Fujino et al., 2023)

Hsap\FUS^RRMmut.UAS, Scer\GAL4^GMR.PS is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PS, Zzzz\GGGGCC^89.UAS

(Fujino et al., 2023)

Hsap\FUS^RRMmut.UAS, Scer\GAL4^GMR.PS is a non-suppressor of embryonic/larval salivary gland | larval stage phenotype of Scer\GAL4^GMR.PS, Zzzz\GGGGCC^89.UAS

(Fujino et al., 2023)

Hsap\FUS^RRMmut.UAS, Scer\GAL4^GMR.PS is a non-suppressor of eye disc phenotype of Scer\GAL4^GMR.PS, Zzzz\GGGGCC^89.UAS

(Fujino et al., 2023)

Hsap\FUS^RRMmut.UAS, Scer\GAL4^GMR.PS is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PS, Zzzz\poly-GR^PO-36.UAS

(Fujino et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hsap\FUS^RRMmut.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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