FlyBase Allele Report: Zzzz\GGGGCC[42.UAS]

General Information

Symbol

Zzzz\GGGGCC^42.UAS

Species

a. artificial

Name

FlyBase ID

FBal0392839

Feature type

allele

Associated gene

Zzzz\GGGGCC

Associated Insertion(s)

Carried in Construct

P{UAS-GGGGCC.42}

Transgenic product class

short_tandem_repeat_expansion

(Fujino et al., 2023)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

short_tandem_repeat_expansion

(Fujino et al., 2023)

Mutagen

in vitro construct

(Fujino et al., 2023)

Progenitor genotype

Carried in construct

P{UAS-GGGGCC.42}

Cytology

Description

UASt regulatory sequences drive expression of 42 repeats of Zzzz\GGGGCC.

(Fujino et al., 2023)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Zzzz\GGGGCC

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

CEA

(Fujino et al., 2023)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

is ameliorated by Hsap\SF3B3^UAS.cFa

(Fujino et al., 2023)

is exacerbated by Hsap\SFPQ^UAS.cFa

(Fujino et al., 2023)

is ameliorated by Hsap\FUS^UAS.cIa

(Fujino et al., 2023)

is ameliorated by Hsap\HNRNPA1^UAS.cFa

(Fujino et al., 2023)

is ameliorated by Hsap\HNRNPA2B1^UAS.cFa

(Fujino et al., 2023)

is exacerbated by Hsap\HNRNPK^UAS.cFa

(Fujino et al., 2023)

is ameliorated by Hsap\HNRNPL^UAS.cFa

(Fujino et al., 2023)

is ameliorated by Hsap\HNRNPR^UAS.cFa

(Fujino et al., 2023)

is ameliorated by Hsap\IGF2BP1^UAS.cFa

(Fujino et al., 2023)

is ameliorated by Hsap\SAFB2^UAS.cFa

(Fujino et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color, with Scer\GAL4^GMR.PS

(Fujino et al., 2023)

decreased rate of adult locomotory behavior, with Scer\GAL4^elav.PLu

(Fujino et al., 2023)

decreased rate of adult locomotory behavior | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Fujino et al., 2023)

partially lethal, with Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, enhanceable by Hsap\HNRNPK^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, enhanceable by Hsap\SFPQ^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, enhanceable by Hsap\DHX30^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, non-enhanceable by Hsap\HNRNPL^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, non-enhanceable by Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, non-enhanceable by Hsap\SAFB^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, non-enhanceable by Hsap\DHX15^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, non-enhanceable by Hsap\ILF2^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, suppressible by Scer\GAL4^GMR.PS/caz^{UAS.x10.Tag:FLAG}

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, suppressible by Hsap\FUS^UAS.cIa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, suppressible by Hsap\IGF2BP1^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, suppressible | partially by Hsap\HNRNPA2B1^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has increased mortality during development phenotype, suppressible by Hsap\FUS^UAS.cIa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^42.UAS has decreased rate of adult locomotory behavior | RU486 conditional phenotype, suppressible by Hsap\FUS^UAS.cIa, Scer\GAL4^{elav.Switch.PO}

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, suppressible | partially by Hsap\FUS^{UAS.10x.Tag:FLAG}, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, suppressible by Hsap\FUS^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, non-suppressible by Hsap\HNRNPR^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, non-suppressible by Hsap\SAFB2^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, non-suppressible by Hsap\SF3B3^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, non-suppressible by Hsap\HNRNPA1^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, non-suppressible by Hsap\HNRNPL^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, non-suppressible by Hsap\SAFB^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, non-suppressible by Hsap\DHX15^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, non-suppressible by Hsap\ILF2^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has abnormal eye color phenotype, non-suppressible by Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has partially lethal phenotype, non-suppressible by Hsap\FUS^RRMmut.UAS, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Other

Statement

Reference

Hsap\ELAVL1^UAS.cFa, Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has lethal phenotype

(Fujino et al., 2023)

Hsap\NONO^UAS.cFa, Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has lethal phenotype

(Fujino et al., 2023)

Hsap\ILF3^UAS.cFa, Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has lethal phenotype

(Fujino et al., 2023)

Hsap\DDX21^UAS.cFa, Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has lethal phenotype

(Fujino et al., 2023)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, enhanceable by Hsap\HNRNPK^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, enhanceable by Hsap\SFPQ^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, enhanceable by Hsap\DHX30^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, non-enhanceable by Hsap\HNRNPL^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, non-enhanceable by Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, non-enhanceable by Hsap\SAFB^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, non-enhanceable by Hsap\DHX15^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, non-enhanceable by Hsap\ILF2^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, suppressible by Scer\GAL4^GMR.PS/caz^{UAS.x10.Tag:FLAG}

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, suppressible by Hsap\FUS^UAS.cIa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, suppressible by Hsap\IGF2BP1^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, suppressible by Hsap\HNRNPA2B1^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, suppressible | partially by Hsap\FUS^{UAS.10x.Tag:FLAG}, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, non-suppressible by Hsap\HNRNPR^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, non-suppressible by Hsap\SAFB2^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, non-suppressible by Hsap\SF3B3^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, non-suppressible by Hsap\HNRNPA1^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, non-suppressible by Hsap\HNRNPL^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, non-suppressible by Hsap\SAFB^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, non-suppressible by Hsap\DHX15^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, non-suppressible by Hsap\ILF2^UAS.cFa, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, non-suppressible by Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Scer\GAL4^GMR.PS, Zzzz\GGGGCC^42.UAS has eye phenotype, non-suppressible by Hsap\FUS^RRMmut.UAS, Scer\GAL4^GMR.PS

(Fujino et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Zzzz\GGGGCC^42.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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