Open Close
General Information
Symbol
Hsap\TARDBPUAS.cIb
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct b of Ishiguro
FlyBase ID
FBal0327172
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of full-length Hsap\TARDBP.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of Hsap\TARDBPScer\UAS.cIb under the control of Scer\GAL4GMR.PS leads to a mild rough eye phenotype, including the thinning of the retina, as compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT suppressed by
Suppressor of
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

The co-expression of Hsap\TARDBPScer\UAS.cIb decreases the severity of the eye defects resulting from the expression of either Zzzz\UGGAAW.Scer\UAS or Zzzz\UGGAAS.Scer\UAS, under the control of Scer\GAL4GMR.PS (i.e. reduced size, loss of pigmentation, defective morphology and ommatidial abnormalities); these partial suppressions of the eye phenotypes are not furthered by the additional co-expression of cazKK107486, Hrb87FKK108162 or Hrb98DEGD14939.

The retina thinning resulting from the expression of Hsap\TARDBPScer\UAS.cIb under the control of Scer\GAL4GMR.PS is partially suppressed by the co-expression of either Zzzz\UGGAA22.Scer\UAS or Zzzz\UGGAAW.Scer\UAS.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Hsap\TARDBPScer\UAS.cIb
Hsap\TARDBPUAS.cIb
Name Synonyms
Saccharomyces cerevisiae UAS construct b of Ishiguro
Secondary FlyBase IDs
    References (1)