FlyBase Allele Report: Zzzz\UGGAA[22.UAS]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Zzzz\UGGAA^22.UAS

General Information

Symbol

Zzzz\UGGAA^22.UAS

Species

a. artificial

Name

FlyBase ID

FBal0327165

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{UAS-UGGAA.22}

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Ishiguro et al., 2017)

Progenitor genotype

Carried in construct

P{UAS-UGGAA.22}

Cytology

Description

UAS regulatory sequences drive expression of 22 Zzzz\UGGAA (a repeat tract associated with human SCA31) repeats, followed by a bridging sequence (complex of UGGGAA, UGGAA, UAGAA) and then a (UAGAA)n, (UAAAA UAGAA)n stretch.

(Ishiguro et al., 2017)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis

modeled by Hsap\TARDBP^{G298S.UAS.cIb}

(Ishiguro et al., 2017)

modeled by Hsap\TARDBP^UAS.cIb

(Ishiguro et al., 2017)

modeled by Hsap\HNRNPA2B1^D290V.UAS

(Ishiguro et al., 2017)

modeled by Hsap\FUS^UAS.cIa

(Ishiguro et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(Ishiguro et al., 2017)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of Zzzz\UGGAA^22.Scer\UAS under the control of either Scer\GAL4^GMR.PS or Scer\GAL4^elav-C155 results in no obvious defects in the adult eye morphology, as compared to controls. Adulthood expression by the combined control of Scer\GAL4^{elav.Switch.PO} and RU486 treatment results in no obvious defects in lifespan or locomotor capacity in negative geotaxis assays, as compared to controls.

(Ishiguro et al., 2017)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS is a suppressor | partially of visible | adult stage phenotype of Hsap\FUS^UAS.cIa, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS is a suppressor | partially of abnormal eye color phenotype of Hsap\FUS^UAS.cIa, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS is a suppressor | partially of visible | adult stage phenotype of Hsap\HNRNPA2B1^D290V.UAS, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS is a suppressor | partially of abnormal eye color phenotype of Hsap\HNRNPA2B1^D290V.UAS, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS is a suppressor | partially of visible | adult stage phenotype of Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS is a suppressor | partially of abnormal size | adult stage phenotype of Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS is a suppressor | partially of visible | adult stage phenotype of Hsap\TARDBP^{G298S.UAS.cIb}, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS is a suppressor | partially of abnormal eye color phenotype of Hsap\TARDBP^{G298S.UAS.cIb}, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Phenotype Manifest In

Suppressor of

Statement

Reference

Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS is a suppressor | partially of eye phenotype of Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS is a suppressor | partially of retina | adult stage phenotype of Hsap\TARDBP^UAS.cIb, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS is a suppressor | partially of ommatidium | adult stage phenotype of Hsap\FUS^UAS.cIa, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS is a suppressor | partially of retina | adult stage phenotype of Hsap\FUS^UAS.cIa, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS is a suppressor | partially of eye phenotype of Hsap\HNRNPA2B1^D290V.UAS, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS is a suppressor | partially of ommatidium | adult stage phenotype of Hsap\HNRNPA2B1^D290V.UAS, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS is a suppressor | partially of retina | adult stage phenotype of Hsap\HNRNPA2B1^D290V.UAS, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS is a suppressor | partially of eye phenotype of Hsap\TARDBP^{G298S.UAS.cIb}, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS is a suppressor | partially of ommatidium | adult stage phenotype of Hsap\TARDBP^{G298S.UAS.cIb}, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS is a suppressor | partially of retina | adult stage phenotype of Hsap\TARDBP^{G298S.UAS.cIb}, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Zzzz\UGGAA^22.UAS, Scer\GAL4^GMR.PS is a suppressor | partially of eye phenotype of Hsap\FUS^UAS.cIa, Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The co-expression of Zzzz\UGGAA^22.Scer\UAS partially suppresses the eye defects observed upon the Scer\GAL4^GMR.PS-driven expression of Hsap\TARDBP^{G298S.Scer\UAS.cIb}, Hsap\FUS^Scer\UAS.cIa or Hsap\HNRNPA2B1^{D290V.Scer\UAS}, and partially suppresses the retina thinning resulting from the Scer\GAL4^GMR.PS-driven expression of Hsap\TARDBP^Scer\UAS.cIb.

(Ishiguro et al., 2017)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Zzzz\UGGAA^22.Scer\UAS

Zzzz\UGGAA^22.UAS

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections