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General Information
Symbol
Zzzz\UGGAA22.UAS
Species
a. artificial
Name
FlyBase ID
FBal0327165
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of 22 Zzzz\UGGAA (a repeat tract associated with human SCA31) repeats, followed by a bridging sequence (complex of UGGGAA, UGGAA, UAGAA) and then a (UAGAA)n, (UAAAA UAGAA)n stretch.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
This allele represents a human variant implicated in disease.
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of Zzzz\UGGAA22.Scer\UAS under the control of either Scer\GAL4GMR.PS or Scer\GAL4elav-C155 results in no obvious defects in the adult eye morphology, as compared to controls. Adulthood expression by the combined control of Scer\GAL4elav.Switch.PO and RU486 treatment results in no obvious defects in lifespan or locomotor capacity in negative geotaxis assays, as compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

The co-expression of Zzzz\UGGAA22.Scer\UAS partially suppresses the eye defects observed upon the Scer\GAL4GMR.PS-driven expression of Hsap\TARDBPG298S.Scer\UAS.cIb, Hsap\FUSScer\UAS.cIa or Hsap\HNRNPA2B1D290V.Scer\UAS, and partially suppresses the retina thinning resulting from the Scer\GAL4GMR.PS-driven expression of Hsap\TARDBPScer\UAS.cIb.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Zzzz\UGGAA22.Scer\UAS
Zzzz\UGGAA22.UAS
Name Synonyms
Secondary FlyBase IDs
    References (2)