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General Information
Symbol
Dmel\Hrb98DEGD14939
Species
D. melanogaster
Name
FlyBase ID
FBal0207321
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Ubiquitous expression of Hrb98DEGD14939 under the control of Scer\GAL4Act5C.PI causes lethality.

Ubiquitous expression of Hrb98DEGD14939 under the control of Scer\GAL4αTub84B.PL causes lethality.

Adults expressing Hrb98DEGD14939 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) show significantly reduced avoidance of noxious temperature (46[o]C) compared to control flies.

Expression under the control of Scer\GAL4Mef2.PR results in grossly normal adult indirect flight muscles.

Expression under the control of Scer\GAL4Mef2.PR results in frayed myofibrils in the adult indirect flight muscles.

Expression under the control of Scer\GAL4Mef2.PR results in sarcomeres with broadened Z-lines in the adult indirect flight muscles.

Expression under the control of Scer\GAL4pnr-MD237 results in extra bristles on the notum in 40-50% or 50-60% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in a colour difference between the central Scer\GAL4pnr-MD237 expression domain of the notum and the surrounding lateral region in 0% or 30-40% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in bristle morphology defects on the notum in 40-50% or 50-60% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in planar polarity defects in the orientation of bristles of the notum in 40-50% or 50-60% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 40-50% or 50-60% of the Scer\GAL4pnr-MD237-expressing area of the notum, depending on the insertion line used.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

The co-expression of Hrb98DEGD14939 does not lead to a decrease in the severity of the eye defects resulting from the Scer\GAL4GMR.PS-driven expression of either Zzzz\UGGAAW.Scer\UAS or Zzzz\UGGAAS.Scer\UAS, alone or in combination with Hsap\TARDBPScer\UAS.cIb (i.e. reduced size, loss of pigmentation, defective morphology and ommatidial abnormalities).

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Hrb98DEGD14939
Name Synonyms
Secondary FlyBase IDs
    References (9)