FlyBase Allele Report: Dmel\Sesn[d04539]

General Information

Symbol

Dmel\Sesn^d04539

Species

D. melanogaster

Name

FlyBase ID

FBal0223949

Feature type

allele

Associated gene

Dmel\Sesn

Associated Insertion(s)

P{XP}Sesn^d04539

Carried in Construct

Also Known As

dSesn^XP4

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{XP}Sesn^d04539

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{XP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:23,713,909..23,713,909 [-]

(Kim et al., 2020, Kim and Lee, 2015, Lee et al., 2010, FlyBase Curators, 2008-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell growth, with Scer\GAL4^ap-md544

(Lee et al., 2010)

abnormal size, with Scer\GAL4^ap-md544

(Kim and Lee, 2015)

visible, with Scer\GAL4^ap-md544

(Kim and Lee, 2015, Lee et al., 2010)

Phenotype Manifest In

wing blade, with Scer\GAL4^ap-md544

(Kim and Lee, 2015, Lee et al., 2010)

Detailed Description

Statement

Reference

When overexpressed in the dorsal wing epithelium under the control of Scer\GAL4^ap-md544, Sesn^d04539 reduces the growth of the target compartment, resulting in a slight bent-up wing phenotype.

(Kim and Lee, 2015)

Overexpression of Sesn^d04539 in dorsal cells of wings driven by Scer\GAL4^ap-md544 results in a phenotype in which the wing bends upward. It appears that the suppressed tissue growth in the dorsal wing compartment results from a decrease in size of the constituent cells.

(Lee et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^ap-md544, Sesn^d04539 has abnormal size phenotype, enhanceable by gig^UAS.cKa/Scer\GAL4^ap-md544

(Kim and Lee, 2015)

Scer\GAL4^ap-md544, Sesn^d04539 has visible phenotype, enhanceable by gig^UAS.cKa/Scer\GAL4^ap-md544

(Kim and Lee, 2015)

NOT Enhanced by

Statement

Reference

Scer\GAL4^ap-md544, Sesn^d04539 has visible phenotype, non-enhanceable by gig^S1338A.UAS/Scer\GAL4^ap-md544

(Kim and Lee, 2015)

Scer\GAL4^ap-md544, Sesn^d04539 has abnormal size phenotype, non-enhanceable by gig^S1338A.UAS/Scer\GAL4^ap-md544

(Kim and Lee, 2015)

Enhancer of

Statement

Reference

Sesn^d04539, Scer\GAL4^ap-md544 is an enhancer of visible phenotype of Pten^UAS.cGa, Scer\GAL4^ap-md544

(Lee et al., 2010)

Sesn^d04539, Scer\GAL4^ap-md544 is an enhancer of visible phenotype of Pi3K92E^A2860C.UAS, Scer\GAL4^ap-md544

(Lee et al., 2010)

Sesn^d04539, Scer\GAL4^ap-md544 is an enhancer of visible phenotype of InR^K1409A.UAS, Scer\GAL4^ap-md544

(Lee et al., 2010)

Sesn^d04539, Scer\GAL4^ap-md544 is an enhancer of visible phenotype of S6k^KQ.UAS, Scer\GAL4^ap-md544

(Lee et al., 2010)

Suppressor of

Statement

Reference

Sesn^d04539, Scer\GAL4^ap-md544 is a suppressor of visible phenotype of Akt^UAS.Exel, Scer\GAL4^ap-md544

(Lee et al., 2010)

Sesn^d04539, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Rheb^UAS.cPa, Scer\GAL4^GMR.PF

(Lee et al., 2010)

Sesn^d04539, Scer\GAL4^ap-md544 is a suppressor of visible phenotype of Pi3K92E^CAAX.UAS, Scer\GAL4^ap-md544

(Lee et al., 2010)

Sesn^d04539, Scer\GAL4^ap-md544 is a suppressor of visible phenotype of InR^A1325D.UAS, Scer\GAL4^ap-md544

(Lee et al., 2010)

Sesn^d04539, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of InR^A1325D.UAS, Scer\GAL4^GMR.PF

(Lee et al., 2010)

NOT Suppressor of

Statement

Reference

Sesn^d04539, Scer\GAL4^ap-md544 is a non-suppressor of visible phenotype of S6k^STDETE.UAS, Scer\GAL4^ap-md544

(Lee et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^ap-md544, Sesn^d04539 has wing blade phenotype, enhanceable by gig^UAS.cKa/Scer\GAL4^ap-md544

(Kim and Lee, 2015)

NOT Enhanced by

Statement

Reference

Scer\GAL4^ap-md544, Sesn^d04539 has wing blade phenotype, non-enhanceable by gig^S1338A.UAS/Scer\GAL4^ap-md544

(Kim and Lee, 2015)

Enhancer of

Statement

Reference

Sesn^d04539, Scer\GAL4^ap-md544 is an enhancer of wing blade phenotype of Pten^UAS.cGa, Scer\GAL4^ap-md544

(Lee et al., 2010)

Sesn^d04539, Scer\GAL4^ap-md544 is an enhancer of wing blade phenotype of Pi3K92E^A2860C.UAS, Scer\GAL4^ap-md544

(Lee et al., 2010)

Sesn^d04539, Scer\GAL4^ap-md544 is an enhancer of wing blade phenotype of InR^K1409A.UAS, Scer\GAL4^ap-md544

(Lee et al., 2010)

Sesn^d04539, Scer\GAL4^ap-md544 is an enhancer of wing blade phenotype of S6k^KQ.UAS, Scer\GAL4^ap-md544

(Lee et al., 2010)

Suppressor of

Statement

Reference

Sesn^d04539, Scer\GAL4^ap-md544 is a suppressor of wing blade phenotype of Akt^UAS.Exel, Scer\GAL4^ap-md544

(Lee et al., 2010)

Sesn^d04539, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Rheb^UAS.cPa, Scer\GAL4^GMR.PF

(Lee et al., 2010)

Sesn^d04539, Scer\GAL4^ap-md544 is a suppressor of wing blade phenotype of Pi3K92E^CAAX.UAS, Scer\GAL4^ap-md544

(Lee et al., 2010)

Sesn^d04539, Scer\GAL4^ap-md544 is a suppressor of wing blade phenotype of InR^A1325D.UAS, Scer\GAL4^ap-md544

(Lee et al., 2010)

Sesn^d04539, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of InR^A1325D.UAS, Scer\GAL4^GMR.PF

(Lee et al., 2010)

NOT Suppressor of

Statement

Reference

Sesn^d04539, Scer\GAL4^ap-md544 is a non-suppressor of wing blade phenotype of S6k^STDETE.UAS, Scer\GAL4^ap-md544

(Lee et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Simultaneous expression of Sesn^d04539 and gig^Scer\UAS.cKa using Scer\GAL4^ap-md544 induces much more pronounced bent-up wing phenotype compared with the phenotype induce Sesn^d04539 expression alone.

(Kim and Lee, 2015)

Co-expression of Sesn^d04539 with InR^{A1325D.Scer\UAS} via Scer\GAL4^GMR.PF suppresses the InR^{A1325D.Scer\UAS} hyperplastic eye phenotype.

Co-expression of Sesn^d04539 with Rheb^Scer\UAS.cPa via Scer\GAL4^GMR.PF suppresses the Rheb^Scer\UAS.cPa hyperplastic eye phenotype.

Co-expression of Sesn^d04539 with InR^{A1325D.Scer\UAS} via Scer\GAL4^ap-md544 suppresses the InR^{A1325D.Scer\UAS} hyperplastic wing phenotype.

Co-expression of Sesn^d04539 with Pi3K92E^{CAAX.Scer\UAS} via Scer\GAL4^ap-md544 suppresses the Pi3K92E^{CAAX.Scer\UAS} hyperplastic wing phenotype.

Co-expression of Sesn^d04539 with Akt1^{Scer\UAS.Exel} via Scer\GAL4^ap-md544 suppresses the Akt1^{Scer\UAS.Exel} hyperplastic wing phenotype.

Co-expression of Sesn^d04539 with S6k^{STDETE.Scer\UAS} via Scer\GAL4^ap-md544 fails to suppress the S6k^{STDETE.Scer\UAS} hyperplastic wing phenotype.

Co-expression of Sesn^d04539 with Pten^Scer\UAS.cGa driven by Scer\GAL4^ap-md544 enhances the wing-bending phenotype of Pten^Scer\UAS.cGa.

Co-expression of Sesn^d04539 with InR^{K1409A.Scer\UAS} driven by Scer\GAL4^ap-md544 enhances the wing-bending phenotype of InR^{K1409A.Scer\UAS}.

Co-expression of Sesn^d04539 with Pi3K92E^{A2860C.Scer\UAS} driven by Scer\GAL4^ap-md544 enhances the wing-bending phenotype of Pi3K92E^{A2860C.Scer\UAS}.

Co-expression of Sesn^d04539 with S6k^KQ.Scer\UAS driven by Scer\GAL4^ap-md544 enhances the wing-bending phenotype of S6k^KQ.Scer\UAS.

(Lee et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

85440

w¹¹¹⁸; P{XP}Sesn^d04539

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG11299^d04539

Sesn^d04539

dSesn^XP4

(Kim et al., 2020, Kim and Lee, 2015, Lee et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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