FlyBase Allele Report: Hsap\TGIF2LX[UAS.Tag:MYC]

General Information

Symbol

Hsap\TGIF2LX^UAS.Tag:MYC

Species

H. sapiens

Name

FlyBase ID

FBal0283556

Feature type

allele

Associated gene

Hsap\TGIF2LX

Associated Insertion(s)

Carried in Construct

P{UAS-TGIF2LX.MYC}

Key Links

Transgenic product class

wild_type

(Wang et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Wang et al., 2008)

Mutagen

in vitro construct

(Wang et al., 2008)

Progenitor genotype

Carried in construct

P{UAS-TGIF2LX.MYC}

Cytology

Description

UAS regulatory sequences drive expression of Hsap\TGIF2LX tagged with Tag:MYC.

(Wang et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\TGIF2LX

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size, with Scer\GAL4^en-e16E

(Wang et al., 2008)

decreased cell number | adult stage, with Scer\GAL4^en-e16E

(Wang et al., 2008)

decreased cell size | adult stage, with Scer\GAL4^en-e16E

(Wang et al., 2008)

decreased cell size | adult stage | somatic clone, with Scer\GAL4^FRT.Act5C

(Wang et al., 2008)

decreased occurrence of cell division | larval stage, with Scer\GAL4^en-e16E

(Wang et al., 2008)

visible, with Scer\GAL4^en-e16E

(Wang et al., 2008)

visible, with Scer\GAL4^sca-537.4

(Wang et al., 2008)

Phenotype Manifest In

adult fat body | somatic clone, with Scer\GAL4^FRT.Act5C

(Wang et al., 2008)

scutellar bristle, with Scer\GAL4^sca-537.4

(Wang et al., 2008)

wing | posterior, with Scer\GAL4^en-e16E

(Wang et al., 2008)

wing disc | posterior, with Scer\GAL4^en-e16E

(Wang et al., 2008)

Detailed Description

Statement

Reference

Fat body cells expressing Hsap\TGIF2LX^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^{Scer\FRT.Act5C} are much smaller than controls.

The scutellar bristles in flies expressing Hsap\TGIF2LX^{Scer\UAS.T:Hsap\MYC} in the sensory organ precursor cells under the control of Scer\GAL4^sca-537.4 are dramatically smaller than controls.

The wings of flies expressing Hsap\TGIF2LX^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^en-e16E have a smaller posterior compartment compared to controls. Cell number and cell size are both reduced. BrdU staining shows that less cell division takes place in the posterior compartment of the wing disc.

(Wang et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^sca-537.4 has visible phenotype, suppressible | partially by Myc^UAS.cZa, Scer\GAL4^sca-537.4

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^sca-537.4 has visible phenotype, suppressible | partially by Hsap\MYC^UAS.S, Scer\GAL4^sca-537.4

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has visible phenotype, suppressible by Myc^UAS.cZa, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has abnormal size phenotype, suppressible by Myc^UAS.cZa, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has decreased cell size | adult stage phenotype, suppressible by Myc^UAS.cZa, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has decreased cell number | adult stage phenotype, suppressible by Myc^UAS.cZa, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has visible phenotype, suppressible by Hsap\MYC^UAS.S, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has abnormal size phenotype, suppressible by Hsap\MYC^UAS.S, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has decreased cell size | adult stage phenotype, suppressible by Hsap\MYC^UAS.S, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has decreased cell number | adult stage phenotype, suppressible by Hsap\MYC^UAS.S, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has visible phenotype, suppressible by CycE^UAS.cLa, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has abnormal size phenotype, suppressible by CycE^UAS.cLa, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has decreased cell size | adult stage phenotype, suppressible by CycE^UAS.cLa, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has decreased cell number | adult stage phenotype, suppressible by CycE^UAS.cLa, Scer\GAL4^en-e16E

(Wang et al., 2008)

NOT suppressed by

Statement

Reference

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has visible phenotype, non-suppressible by Pi3K92E^UAS.Tag:MYC, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has abnormal size phenotype, non-suppressible by Pi3K92E^UAS.Tag:MYC, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has decreased cell size | adult stage phenotype, non-suppressible by Pi3K92E^UAS.Tag:MYC, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has decreased cell number | adult stage phenotype, non-suppressible by Pi3K92E^UAS.Tag:MYC, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^sca-537.4 has visible phenotype, non-suppressible by InR^A1325D.UAS, Scer\GAL4^sca-537.4

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^sca-537.4 has visible phenotype, non-suppressible by Pi3K92E^UAS.Tag:MYC, Scer\GAL4^sca-537.4

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has visible phenotype, non-suppressible by InR^A1325D.UAS, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has abnormal size phenotype, non-suppressible by InR^A1325D.UAS, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has decreased cell size | adult stage phenotype, non-suppressible by InR^A1325D.UAS, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has decreased cell number | adult stage phenotype, non-suppressible by InR^A1325D.UAS, Scer\GAL4^en-e16E

(Wang et al., 2008)

Phenotype Manifest In

Suppressed by

Statement

Reference

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^sca-537.4 has scutellar bristle phenotype, suppressible | partially by Myc^UAS.cZa, Scer\GAL4^sca-537.4

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^sca-537.4 has scutellar bristle phenotype, suppressible | partially by Hsap\MYC^UAS.S, Scer\GAL4^sca-537.4

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has wing | posterior phenotype, suppressible by Myc^UAS.cZa, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has wing | posterior phenotype, suppressible by Hsap\MYC^UAS.S, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has wing | posterior phenotype, suppressible by CycE^UAS.cLa, Scer\GAL4^en-e16E

(Wang et al., 2008)

NOT suppressed by

Statement

Reference

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^sca-537.4 has scutellar bristle phenotype, non-suppressible by InR^A1325D.UAS, Scer\GAL4^sca-537.4

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^sca-537.4 has scutellar bristle phenotype, non-suppressible by Pi3K92E^UAS.Tag:MYC, Scer\GAL4^sca-537.4

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has wing | posterior phenotype, non-suppressible by InR^A1325D.UAS, Scer\GAL4^en-e16E

(Wang et al., 2008)

Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E has wing | posterior phenotype, non-suppressible by Pi3K92E^UAS.Tag:MYC, Scer\GAL4^en-e16E

(Wang et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of dm^Scer\UAS.cZa partially suppresses the growth phenotypes seen in the wings and bristles of flies expressing Hsap\TGIF2LX^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^en-e16E or Scer\GAL4^sca-537.4 respectively.

Expression of Hsap\MYC^Scer\UAS.S partially suppresses the growth phenotypes seen in the wings and bristles of flies expressing Hsap\TGIF2LX^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^en-e16E or Scer\GAL4^sca-537.4 respectively.

Expression of CycE^Scer\UAS.cLa partially suppresses the growth phenotype seen in the wings of flies expressing Hsap\TGIF2LX^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^en-e16E.

Expression of InR^{A1325D.Scer\UAS} is unable to suppress the growth phenotypes seen in the wings and bristles of flies expressing Hsap\TGIF2LX^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^en-e16E or Scer\GAL4^sca-537.4 respectively.

Expression of Pi3K92E^{Scer\UAS.T:Hsap\MYC} is unable to suppress the growth phenotypes seen in the wings and bristles of flies expressing Hsap\TGIF2LX^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^en-e16E or Scer\GAL4^sca-537.4 respectively.

(Wang et al., 2008)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\TGIF2LX^{Scer\UAS.T:Hsap\MYC}

Hsap\TGIF2LX^UAS.Tag:MYC

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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