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General Information
Symbol
Dmel\HDAC1JF01401
Species
D. melanogaster
Name
FlyBase ID
FBal0245672
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies expressing HDAC1JF01401 under the control of Scer\GAL4fat exhibit significantly shorter survival time under starvation stress, as compared to controls.

Expression of HDAC1JF01401 results in: small and rough adult eye phenotype (with Scer\GAL4ey.PH), held out wings with vein defects (with Scer\GAL4nub.PK), missing as well as ectopic wing veins (with Scer\GAL4en.PU) expression controlled by Scer\GAL4GMR.PF has no overt adult phenotype.

Expression of HDAC1JF01401 under the control of Scer\GAL4Act.PU results in lethality.

Expression of HDAC1JF01401 under the control of Scer\GAL4arm.PU leads to increased lifespan and increased survival to paraquat-induced oxidative stress, as compared to controls.

Expression of HDAC1JF01401 under the control of Scer\GAL4tin.CΔ4 in males leads to increased survival to paraquat-induced oxidative stress, starvation, or heat stress, as compared to controls; in females, the same expression leads to increased survival to paraquat-induced oxidative stress and starvation, but not to heat stress.

Adults expressing HDAC1JF01401 under the control of Scer\GAL4tin.CΔ4 display increased heart rate under either control conditions (no stress), paraquat-induced oxidative stress or heat stress, as compared to wild-type controls; expression of HDAC1JF01401 under the control of Scer\GAL4tin.CΔ4 increases the heart recovery rate and decreases the heart failure rate after electric shocks in animals under paraquat-induced oxidative stress, as compared to equally stressed controls; this expression of HDAC1JF01401 under the control of Scer\GAL4tin.CΔ4 has no significant effect in the overall lifespan, as compared to controls.

Expression of HDAC1JF01401 under the control of Scer\GAL4r4 is semi-lethal in males and does not improve survival under paraquat-induced oxidative stress in adult females, as compared to wild-type controls.

Expression of HDAC1JF01401 under the control of Scer\GAL4GMR.PU in adult does not increase survival to paraquat-induced oxidative stress; it does not increase the heart rate or decrease the heart failure rate after electric shock; it also does not have an obvious effect on the eye morphology.

Expression of HDAC1JF01401 under the control of both Scer\GAL4GMR.PU and Scer\GAL4Scer\UAS.cHa improves survival to paraquat-induced oxidative stress and increases the lifespan and heart rate under control conditions (absence of stress), as compared to wild-type control animals.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Additional Comments
Genetic Interactions
Statement
Reference

The eye or wing phenotype induced by expression of HDAC1JF01401 under the control of either Scer\GAL4ey.PH or Scer\GAL4nub.PK, respectively, is weakly enhanced by combination with httint or by co-expression of httGD14943.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
HDAC1JF01401
Rpd3JF01401
Name Synonyms
Secondary FlyBase IDs
    References (5)