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General Information
Symbol
Dmel\httGD14943
Species
D. melanogaster
Name
FlyBase ID
FBal0209709
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of httGD14943 under the control of either Scer\GAL4en.PU or Scer\GAL4nub.PK does not lead to any obvious adult wing defects.

Expression of httGD14943 under the control of Scer\GAL4insc.PU results in mitotic spindle positioning defects in third instar larval neuroblasts: in contrast to wild-type controls, a significant proportion of cells show spindles with the angle between centrosomal pole and center of the mira protein crescent higher than the 15[o].

Adults expressing httGD14943 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
Other
Phenotype Manifest In
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

The ovarian defects observed in females expressing Su(var)3-3GD9296 under the control of Scer\GAL4Act5C.PI as well as the ectopic venation phenotype induced by Scer\GAL4en.PU-driven expression of Su(var)3-3GD9296 are enhanced by co-expression of httGD14943.

Co-expression with httGD14943 enhances, to a varying degree, the adult wing phenotypes induced by expression of any of the following: HDAC1JF01401, HDAC6HMS00077, Su(var)3-3GD9296, Jarid2JF02081, ash1JF01498, Snr1GD4140, notJF03152, escGD1240, Set1GD12893, escJF01403, Mt2GD5033, brmHM04019, gppJF01283, or RgaGL00386 (controlled by Scer\GAL4nub.PK or Scer\GAL4en.PU).

Adult flies co-expressing httGD14943 and any of the following: JHDM2HMS00775, Jarid2HMS00679, AsxJF01708, AsxKK102222, gppJF01284 and Su(var)205KK110828 under the control of Scer\GAL4en.PU display ectopic wing vein phenotype.

Co-expression of httGD14943 suppresses the adult eye phenotype induced by expression of E(Pc)JF03101 (under the control of either Scer\GAL4ey.PH or Scer\GAL4GMR.PF) or E(Pc)GL00169 (driven by Scer\GAL4ey.PH), whereas it enhances the eye defects observed upon expression of HDAC1JF01401 or brmK804R.Scer\UAS.T:Ivir\HA1 (with Scer\GAL4ey.PH) or E2f1dsRNA.Scer\UAS.cJa (with Scer\GAL4GMR.PF).

The various wing defects induced by expression of either HP1bKK108772 or Su(var)205KK110828 under the control of Scer\GAL4nub.PK or Scer\GAL4en.PU are both enhanced and suppressed by co-expression of httGD14943 - the ectopic venation phenotype is enhanced while the wing notches are suppressed.

The adult eye phenotype induced by expression of Sin3AHMS00359 under the control of Scer\GAL4ey.PH is suppressed by co-expression of httGD14943, the wing phenotype observed with the Scer\GAL4en.PU driver is both enhanced and suppressed by co-expression of httGD14943 - it suppresses the L5 wing vein defect but enhances the ectopic posterior crossvein phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
httGD14943
Name Synonyms
Secondary FlyBase IDs
    References (7)