FlyBase Allele Report: Dmel\Kdm5[HM05155]

General Information

Symbol

Dmel\Kdm5^HM05155

Species

D. melanogaster

Name

FlyBase ID

FBal0240284

Feature type

allele

Associated gene

Dmel\Kdm5

Associated Insertion(s)

Carried in Construct

P{TRiP.HM05155}

Also Known As

lid RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HM05155}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HM05155

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of autism spectrum disorder

CEA

(Chen et al., 2019)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of autism spectrum disorder

is ameliorated by imd^HMS00253

(Chen et al., 2019)

ameliorates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^UAS.cEa

(Berson et al., 2017)

exacerbates cancer

modeled by Rbf^HMS03004

(Parkhitko et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal, with Scer\GAL4^Act5C.PI

(Dietz et al., 2015)

visible | adult stage, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

Phenotype Manifest In

posterior crossvein, with Scer\GAL4^nub.PK

(Dietz et al., 2015)

Detailed Description

Statement

Reference

Expression of lid^HM05155 under the control of Scer\GAL4^Act5C.PI is lethal and when driven by Scer\GAL4^nub.PK results in occasional posterior crossveins defects. Expression controlled by any of the following: Scer\GAL4^ey.PH, Scer\GAL4^GMR.PF or Scer\GAL4^en.PU has no overt adult phenotype.

(Dietz et al., 2015)

Scer\GAL4^upd1-E132 or Scer\GAL4^C587 driven knockdown of lid^HM05155 does not affect germline stem cell number or average hub area in the testes.

(Tarayrah et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Kdm5^HM05155, Scer\GAL4^nub.PK has visible | female | adult stage phenotype, suppressible by htt^GD14943, Scer\GAL4^nub.PK

(Dietz et al., 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

Kdm5^HM05155, Scer\GAL4^nub.PK has wing blade | female phenotype, suppressible by htt^GD14943, Scer\GAL4^nub.PK

(Dietz et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The wing phenotype induced by expression of lid^HM05155 under the control of Scer\GAL4^nub.PK can be suppressed (in females only) by co-expression of htt^GD14943.

(Dietz et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

28944

y¹ v¹; P{TRiP.HM05155}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Kdm5^HM05155

kdm5^RNAi

(Chen et al., 2019)

lid^HM05155

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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