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General Information
Symbol
Dmel\httint
Species
D. melanogaster
Name
FlyBase ID
FBal0324927
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Targeting event that has resulted in a partial duplication of the htt locus. The sequence consists of 1. htt exons 1 through 8, in which exons 3 and 4 and part of exon 5 have been deleted, 2. a mini-w[+] marker and 3. exons 2 through to the 3' end of the htt transcription unit.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The longevity of httint mutant adult flies is comparable to wild-type.

The positional effect variegation (PEV) at the Sb locus caused by T(2;3)SbV or at the y locus caused by In(1)y3P is significantly suppressed by single copy of httint.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

httint is an enhancer of visible | adult stage phenotype of Su(var)3-3ΔN

Suppressor of
Phenotype Manifest In
Enhancer of
Statement
Reference

httint/htt[+] is an enhancer of eye phenotype of E2f1dsRNA.UAS.cJa, Scer\GAL4GMR.PF

httint is an enhancer of wing phenotype of Scer\GAL4en.PU, ash1JF01498

httint is an enhancer of wing phenotype of Mt2GD5033, Scer\GAL4en.PU

httint is an enhancer of wing phenotype of Scer\GAL4en.PU, gppJF01283

httint is an enhancer of eye phenotype of HDAC1JF01401, Scer\GAL4ey.PH

Suppressor of
Statement
Reference

httint is a suppressor of eye phenotype of E(Pc)JF03101, Scer\GAL4ey.PH

httint is a suppressor of wing phenotype of Scer\GAL4en.PU, Sin3AHMS00359

httint/htt[+] is a suppressor of eye phenotype of Scer\GAL4ey.PH, Sin3AHMS00359

httint is a suppressor of eye phenotype of E(Pc)JF03101, Scer\GAL4GMR.PF

httint is a suppressor of wing phenotype of Orc2KK102852, Scer\GAL4nub.PK

Additional Comments
Genetic Interactions
Statement
Reference

The ovarian defects observed in females expressing Su(var)3-3GD9296 under the control of Scer\GAL4Act5C.PI as well as the ectopic venation phenotype induced by Scer\GAL4en.PU-driven expression of Su(var)3-3GD9296 are enhanced by combination with httint.

The adult eye induced by expression of HDAC1JF01401 under the control of Scer\GAL4ey.PH or by expression of E2f1dsRNA.Scer\UAS.cJa driven by Scer\GAL4GMR.PF is weakly enhanced by combination with httint, whereas the eye defects observed upon expression of E(Pc)JF03101 (under the control of either Scer\GAL4ey.PH or Scer\GAL4GMR.PF) are suppressed by combination with httint.

Combination with httint enhances, to a varying degree, the adult wing phenotypes induced by expression of any of the following: HDAC1JF01401, Su(var)3-3GD9296, Jarid2JF02081, Su(z)12JF01706, ash1JF01498, trxJF01557, brmGD4507, Mt2GD5033, brmHM04019, gppJF01283, RgaGL00386 or HP1bKK108772 (controlled by Scer\GAL4nub.PK or Scer\GAL4en.PU) and suppresses the wing defects induced by expression of Su(var)205KK110828, Sin3AHMS00359 (driven by Scer\GAL4en.PU) or Orc2KK102852 (driven by Scer\GAL4nub.PK).

The penetrance of the ectopic venation phenotype observed in Su(var)3-3ΔN homozygous adults is significantly increased upon combination with httint.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)