FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\puml1
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General Information
Symbol
Dmel\puml1
Species
D. melanogaster
Name
FlyBase ID
FBal0352217
Feature type
allele
Associated gene
Dmel\puml
Associated Insertion(s)
P{?SUPor-P}puml1
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Hehlert et al., 2019)
Progenitor genotype
P{SUPor-P}pumlKG09852
(Hehlert et al., 2019)
Associated Insertion(s)
P{?SUPor-P}puml1
Cytology
Description

Mobilization of the P{SUPor-P}pumlKG09852 progenitor, resulting in an imprecise excision with 12 bp residual P-element sequence remaining between the deletion breakpoints and the puml gene locus being devoid of coding DNA sequence from position 188-2369 relative to the transcription start of puml-RA.

(Hehlert et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2R:7,812,693..7,814,874 [+]
Comment:

Sequences from 188-2369 relative to the puml-RA transcription start are removed by imprecise excision of P{SUPor-P}pumlKG09852. 12 bases of residual P element sequence remain at the site.

(Hehlert et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  obesity
      CEA
      (Hehlert et al., 2019)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      puml1 homozygous mutants have significantly reduced startle-induced climbing, compared to controls, with no effect on spontaneous locomotion, respiratory rate or food intake; they have significantly reduced survival under desiccation conditions, but significantly increased survival under starvation conditions, compared to controls, with no effect on survival under salt stress conditions; in the Malpighian tubules, there are more lipid droplets, which are significantly smaller than lipid droplets of controls, and significantly larger mitochondria, compared to controls.

      (Hehlert et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      puml1 is rescued by pumlUAS.PA/Scer\GAL4Act5C.PI

      (Hehlert et al., 2019)
      Partially rescued by

      puml1 is partially rescued by pumlUAS.PA/Scer\GAL4Uro.PT

      (Hehlert et al., 2019)

      puml1 is partially rescued by pumlUAS.PA/Scer\GAL4fat

      (Hehlert et al., 2019)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      puml1
      (Hehlert et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)