FlyBase Allele Report: Dmel\bmm[UAS.EGFP]

General Information

Symbol

Dmel\bmm^UAS.EGFP

Species

D. melanogaster

Name

FlyBase ID

FBal0195577

Feature type

allele

Associated gene

Dmel\bmm

Associated Insertion(s)

Carried in Construct

P{UAS-bmm.EGFP}

Also Known As

UAS-bmm

Key Links

Transgenic product class

cDNA

(Gronke et al., 2005)

wild_type

(Gronke et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Gronke et al., 2005)

wild_type

(Gronke et al., 2005)

Mutagen

in vitro construct

(Gronke et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-bmm.EGFP}

Cytology

Description

UASt regulatory sequences drive expression of full-length bmm (coding sequence derived from cDNA), tagged with EGFP.

(Gronke et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

bmm

Tagged with

EGFP

green fluorescent protein

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates obesity

modeled by Grasp65³⁰²

(Kim et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased size, with Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Phenotype Manifest In

adult fat body, with Scer\GAL4^fat

(Gronke et al., 2005)

lipid droplet, with Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Detailed Description

Statement

Reference

Expression of bmm^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^fat depletes organismal triacylglycerol storage and reduces both the number and size of lipid droplets in fat body cells of immature adult flies.

(Gronke et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

bmm^UAS.EGFP/Scer\GAL4^Cg.PU is a suppressor of increased size phenotype of Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A}

(Sheng et al., 2025)

bmm^UAS.EGFP/Scer\GAL4^GMR.PU is a suppressor | partially of abnormal neurophysiology | adult stage phenotype of mir-210^Δ

(Weigelt et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

bmm^UAS.EGFP/Scer\GAL4^Cg.PU is a suppressor of lipid droplet phenotype of Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A}

(Sheng et al., 2025)

bmm^UAS.EGFP/Scer\GAL4^GMR.PU is a suppressor | partially of retina phenotype of mir-210^Δ

(Weigelt et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

bmm^UAS.EGFP/Scer\GAL4^Act5C.PI rescues bmm¹

(Gronke et al., 2005)

Comments

Expression of bmm^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^Act5C.PI reverts the obese phenotype of bmm¹ mutant flies.

(Gronke et al., 2005)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

98110

w^*; P{UAS-bmm.EGFP}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

bmm^{Scer\UAS.T:Avic\GFP-EGFP}

bmm^UAS.EGFP

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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