FlyBase Allele Report: Dmel\mir-210[Δ]

General Information

Symbol

Dmel\mir-210^Δ

Species

D. melanogaster

Name

FlyBase ID

FBal0346250

Feature type

allele

Associated gene

Dmel\mir-210

Associated Insertion(s)

Carried in Construct

Also Known As

miR-210Δ

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Weigelt et al., 2019)

Mutagen

CRISPR/Cas9

(Weigelt et al., 2019)

Progenitor genotype

Cytology

Description

Deletion of the mir-210 gene.

(Weigelt et al., 2019)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage

(Colaianni et al., 2024, Weigelt et al., 2019)

abnormal neuroanatomy | adult stage (with Df(1)BSC352)

(Weigelt et al., 2019)

abnormal neurophysiology | adult stage

(Weigelt et al., 2019)

decreased cell number | adult stage

(Weigelt et al., 2019)

long lived | male limited

(Weigelt et al., 2019)

Phenotype Manifest In

eye photoreceptor cell

(Weigelt et al., 2019)

eye photoreceptor cell | adult stage

(Colaianni et al., 2024)

ommatidium | adult stage

(Colaianni et al., 2024)

retina

(Weigelt et al., 2019)

retina (with Df(1)BSC352)

(Weigelt et al., 2019)

rhabdomere of eye photoreceptor cell

(Weigelt et al., 2019)

vacuole | adult stage

(Weigelt et al., 2019)

Detailed Description

Statement

Reference

mir-210^Δ homozygous mutants have no difference in adult eclosion under hypoxic (10 percent oxygen) conditions, relative to normoxic conditions, compared to controls; males, but not females, have a slight but significant increase in lifespan, compared to controls; there is no difference in adult survival of 14 h hypoxia (1 percent oxygen), or starvation survival, compared to controls; there is a slight, but significant increase in adult weight, but no difference in fecundity, compared to controls; photoreceptor cell arrangement, integrity and rhabdomere morphology becomes increasingly dissimilar to controls with increasing adult age in mir-210^Δ mutants, with abnormal appearance of vacuoles following loss of photoreceptor cells; this retinal degeneration occurs under constant light, light-dark or constant dark conditions; receptor potential (measured by electroretinogram) also decreases relative to controls with increasing age, being significantly lower at 10 d and 4 2 d, but not 0 d; mir-210^Δ/Df(1)BSC352 mutant adults also have increased retinal degeneration by 4 d post-eclosion, unlike controls.

(Weigelt et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

mir-210^Δ has abnormal neurophysiology | adult stage phenotype, non-enhanceable by BacA\p35^GMR.PH

(Weigelt et al., 2019)

mir-210^Δ has abnormal neurophysiology | adult stage phenotype, non-enhanceable by Scer\GAL4^GMR.PU/Apc^GD1333