FlyBase Allele Report: Dmel\babo[RNAi.circbabo(5,6,7,8S).UAS.A]

General Information

Symbol

Dmel\babo^{RNAi.circbabo(5,6,7,8S).UAS.A}

Species

D. melanogaster

Name

FlyBase ID

FBal0407800

Feature type

allele

Associated gene

Dmel\babo

Associated Insertion(s)

Carried in Construct

P{UAS-shcircbabo(5-6-7-8S).A}

Key Links

Transgenic product class

RNAi_reagent

(Sheng et al., 2025)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Sheng et al., 2025)

Mutagen

in vitro construct

(Sheng et al., 2025)

Progenitor genotype

Carried in construct

P{UAS-shcircbabo(5-6-7-8S).A}

Cytology

Description

UAS regulates expression of an shRNA targeting the the 'circbabo(5,6,7,8S)' circular RNA, which is generated by a backsplicing reaction of babo exons 5, 6, 7 and the first part of exon 8.

(Sheng et al., 2025)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

babo

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^elav.PU

(Sheng et al., 2025)

abnormal neuroanatomy | adult stage, with Scer\GAL4^repo.PU

(Sheng et al., 2025)

abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4^GMR.PU

(Sheng et al., 2025)

decreased cell number | adult stage, with Scer\GAL4^elav.PU

(Sheng et al., 2025)

decreased cell number | adult stage, with Scer\GAL4^repo.PU

(Sheng et al., 2025)

decreased cell number | adult stage | progressive, with Scer\GAL4^GMR.PU

(Sheng et al., 2025)

increased size, with Scer\GAL4^ppl.PU

(Sheng et al., 2025)

increased size | larval stage, with Scer\GAL4^Cg.PU

(Sheng et al., 2025)

short lived, with Scer\GAL4^nSyb.PU

(Sheng et al., 2025)

Phenotype Manifest In

embryonic/larval fat body | larval stage, with Scer\GAL4^Cg.PU

(Sheng et al., 2025)

eye photoreceptor cell | adult stage | decreased number, with Scer\GAL4^elav.PU

(Sheng et al., 2025)

eye photoreceptor cell | adult stage | decreased number, with Scer\GAL4^GMR.PU

(Sheng et al., 2025)

eye photoreceptor cell | adult stage | decreased number, with Scer\GAL4^repo.PU

(Sheng et al., 2025)

fat body, with Scer\GAL4^ppl.PU

(Sheng et al., 2025)

lipid droplet, with Scer\GAL4^ppl.PU

(Sheng et al., 2025)

lipid droplet | adult stage, with Scer\GAL4^elav.PU

(Sheng et al., 2025)

lipid droplet | adult stage, with Scer\GAL4^GMR.PU

(Sheng et al., 2025)

lipid droplet | larval stage, with Scer\GAL4^Cg.PU

(Sheng et al., 2025)

ommatidium | adult stage, with Scer\GAL4^elav.PU

(Sheng et al., 2025)

ommatidium | adult stage, with Scer\GAL4^GMR.PU

(Sheng et al., 2025)

ommatidium | adult stage, with Scer\GAL4^repo.PU

(Sheng et al., 2025)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has increased size phenotype, non-enhanceable by foxo^HMS00793/Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has increased size phenotype, non-enhanceable by Rel^HMS00070, Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has decreased cell number | adult stage | progressive phenotype, suppressible | partially by Hsap\SOD1^UAS.cUa, Scer\GAL4^GMR.PU

(Sheng et al., 2025)

Scer\GAL4^nSyb.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has short lived phenotype, suppressible by Hsap\SOD1^UAS.cUa, Scer\GAL4^nSyb.PU

(Sheng et al., 2025)

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has increased size phenotype, suppressible by bmm^UAS.EGFP/Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has increased size phenotype, suppressible by Lsd-2^HMS00629, Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has increased size phenotype, suppressible by SREBP^RNAi.UAS.cUa, Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has increased size phenotype, suppressible by SREBP[+]/SREBP¹⁸⁹

(Sheng et al., 2025)

Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has abnormal neuroanatomy | adult stage | progressive phenotype, suppressible | partially by SREBP[+]/SREBP¹⁸⁹

(Sheng et al., 2025)

Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has decreased cell number | adult stage | progressive phenotype, suppressible | partially by SREBP[+]/SREBP¹⁸⁹

(Sheng et al., 2025)

Scer\GAL4^nSyb.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has short lived phenotype, suppressible by SREBP^RNAi.UAS.cUa, Scer\GAL4^nSyb.PU

(Sheng et al., 2025)

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has increased size phenotype, suppressible by bsk^HMS00777/Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has abnormal neuroanatomy | adult stage | progressive phenotype, suppressible | partially by bsk^HMS00777/Scer\GAL4^GMR.PU

(Sheng et al., 2025)

Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has decreased cell number | adult stage | progressive phenotype, suppressible | partially by bsk^HMS00777/Scer\GAL4^GMR.PU

(Sheng et al., 2025)

Scer\GAL4^nSyb.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has short lived phenotype, suppressible by Scer\GAL4^nSyb.PU/bsk^HMS00777

(Sheng et al., 2025)

Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has abnormal neuroanatomy | adult stage | progressive phenotype, suppressible by SREBP^RNAi.UAS.cUa, Scer\GAL4^GMR.PU

(Sheng et al., 2025)

Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has decreased cell number | adult stage | progressive phenotype, suppressible by SREBP^RNAi.UAS.cUa, Scer\GAL4^GMR.PU

(Sheng et al., 2025)

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has increased size phenotype, suppressible by Hsap\SOD1^UAS.cUa, Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has abnormal neuroanatomy | adult stage | progressive phenotype, suppressible | partially by Hsap\SOD1^UAS.cUa, Scer\GAL4^GMR.PU

(Sheng et al., 2025)

NOT suppressed by

Statement

Reference

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has increased size phenotype, non-suppressible by foxo^HMS00793/Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has increased size phenotype, non-suppressible by Rel^HMS00070, Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has lipid droplet phenotype, non-enhanceable by foxo^HMS00793/Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has lipid droplet phenotype, non-enhanceable by Rel^HMS00070, Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Suppressed by

Statement

Reference

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has lipid droplet phenotype, suppressible by bmm^UAS.EGFP/Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has lipid droplet phenotype, suppressible by Lsd-2^HMS00629, Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has lipid droplet phenotype, suppressible by SREBP^RNAi.UAS.cUa, Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has lipid droplet phenotype, suppressible by SREBP[+]/SREBP¹⁸⁹

(Sheng et al., 2025)

Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has eye photoreceptor cell | adult stage | decreased number phenotype, suppressible | partially by SREBP[+]/SREBP¹⁸⁹

(Sheng et al., 2025)

Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has ommatidium | adult stage phenotype, suppressible | partially by SREBP[+]/SREBP¹⁸⁹

(Sheng et al., 2025)

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has lipid droplet phenotype, suppressible by bsk^HMS00777/Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has fat body phenotype, suppressible by bsk^HMS00777/Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has eye photoreceptor cell | adult stage | decreased number phenotype, suppressible | partially by bsk^HMS00777/Scer\GAL4^GMR.PU

(Sheng et al., 2025)

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has fat body phenotype, suppressible by SREBP^RNAi.UAS.cUa, Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has ommatidium | adult stage phenotype, suppressible | partially by bsk^HMS00777/Scer\GAL4^GMR.PU

(Sheng et al., 2025)

Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has eye photoreceptor cell | adult stage | decreased number phenotype, suppressible by SREBP^RNAi.UAS.cUa, Scer\GAL4^GMR.PU

(Sheng et al., 2025)

Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has ommatidium | adult stage phenotype, suppressible by SREBP^RNAi.UAS.cUa, Scer\GAL4^GMR.PU

(Sheng et al., 2025)

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has lipid droplet phenotype, suppressible by Hsap\SOD1^UAS.cUa, Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has lipid droplet | adult stage phenotype, suppressible | partially by Hsap\SOD1^UAS.cUa, Scer\GAL4^GMR.PU

(Sheng et al., 2025)

Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has eye photoreceptor cell | adult stage | decreased number phenotype, suppressible | partially by Hsap\SOD1^UAS.cUa, Scer\GAL4^GMR.PU

(Sheng et al., 2025)

Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has ommatidium | adult stage phenotype, suppressible | partially by Hsap\SOD1^UAS.cUa, Scer\GAL4^GMR.PU

(Sheng et al., 2025)

NOT suppressed by

Statement

Reference

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has lipid droplet phenotype, non-suppressible by foxo^HMS00793/Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A} has lipid droplet phenotype, non-suppressible by Rel^HMS00070, Scer\GAL4^Cg.PU

(Sheng et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

babo^{RNAi.circbabo(5,6,7,8S).UAS.A} is rescued by Scer\GAL4^Cg.PU/babo^{circbabo(5,6,7,8S)-p.UAS.Tag:FLAG}

(Sheng et al., 2025)

babo^{RNAi.circbabo(5,6,7,8S).UAS.A} is rescued by babo^{circbabo(5,6,7,8S)-p.UAS.Tag:FLAG}/Scer\GAL4^GMR.PU

(Sheng et al., 2025)

babo^{RNAi.circbabo(5,6,7,8S).UAS.A} is rescued by Scer\GAL4^nSyb.PU/babo^{circbabo(5,6,7,8S)-p.UAS.Tag:FLAG}

(Sheng et al., 2025)

babo^{RNAi.circbabo(5,6,7,8S).UAS.A} is rescued by Scer\GAL4^Cg.PU/babo^{circbabo(5,6,7,8S).UAS}

(Sheng et al., 2025)

babo^{RNAi.circbabo(5,6,7,8S).UAS.A} is rescued by babo^{circbabo(5,6,7,8S).UAS}/Scer\GAL4^GMR.PU

(Sheng et al., 2025)

babo^{RNAi.circbabo(5,6,7,8S).UAS.A} is rescued by Scer\GAL4^elav.PU/babo^{circbabo(5,6,7,8S).UAS}

(Sheng et al., 2025)

babo^{RNAi.circbabo(5,6,7,8S).UAS.A} is rescued by Scer\GAL4^nSyb.PU/babo^{circbabo(5,6,7,8S).UAS}

(Sheng et al., 2025)

babo^{RNAi.circbabo(5,6,7,8S).UAS.A} is rescued by Scer\GAL4^repo.PU/babo^{circbabo(5,6,7,8S).UAS}

(Sheng et al., 2025)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

babo^{RNAi.circbabo(5,6,7,8S).UAS.A}

Name Synonyms

Secondary FlyBase IDs

References (1)

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