FlyBase Allele Report: Dmel\bsk[HMS00777]

General Information

Symbol

Dmel\bsk^HMS00777

Species

D. melanogaster

Name

FlyBase ID

FBal0257458

Feature type

allele

Associated gene

Dmel\bsk

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00777}

Also Known As

UAS-bsk^RNAi, UAS-Bsk-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00777}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00777

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates colorectal cancer

modeled by Ras85D^V12.UAS

(Bangi et al., 2012)

ameliorates lower respiratory tract disease

modeled by PGRP-LC^x.UAS

(Wagner et al., 2021)

ameliorates cancer

modeled by Raf^F22.hs

(Zhao et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expressing bsk^HMS00777 under the control of Scer\GAL4^GMR71G10 does not induce mushroom body gamma neuron pruning defects.

(Meltzer et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

bsk^HMS00777/Scer\GAL4^Cg.PU is a suppressor of increased size phenotype of Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A}

(Sheng et al., 2025)

bsk^HMS00777/Scer\GAL4^GMR.PU is a suppressor | partially of abnormal neuroanatomy | adult stage | progressive phenotype of Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A}

(Sheng et al., 2025)

bsk^HMS00777/Scer\GAL4^GMR.PU is a suppressor | partially of decreased cell number | adult stage | progressive phenotype of Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A}

(Sheng et al., 2025)

Scer\GAL4^nSyb.PU/bsk^HMS00777 is a suppressor of short lived phenotype of Scer\GAL4^nSyb.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A}

(Sheng et al., 2025)

bsk^HMS00777/Scer\GAL4^NP5130 is a suppressor of increased cell number | adult stage phenotype of Scer\GAL4^NP5130, TER94^HMS00656

(Liu et al., 2022)

Scer\GAL4^Act.PU/bsk^HMS00777 is a suppressor of increased cell number | somatic clone | adult stage phenotype of TER94^k15502

(Liu et al., 2022)

Scer\GAL4^Act.PU/bsk^HMS00777 is a suppressor of increased cell number | somatic clone | adult stage phenotype of Der-1^Δ

(Liu et al., 2022)

Scer\GAL4^Act.PU/bsk^HMS00777 is a suppressor of increased cell number | somatic clone | adult stage phenotype of Der-1^SH1964

(Liu et al., 2022)

bsk^HMS00777/Scer\GAL4^NP5130 is a suppressor of increased cell number | adult stage phenotype of Scer\GAL4^NP5130, TER94^GL00448

(Liu et al., 2022)

bsk^HMS00777, Scer\GAL4^byn-Gal4 is a suppressor | partially of abnormal cell migration | adult stage | progressive phenotype of Ras85D^V12.UAS, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

bsk^HMS00777/Scer\GAL4^Cg.PU is a suppressor of lipid droplet phenotype of Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A}

(Sheng et al., 2025)

bsk^HMS00777/Scer\GAL4^Cg.PU is a suppressor of fat body phenotype of Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A}

(Sheng et al., 2025)

bsk^HMS00777/Scer\GAL4^GMR.PU is a suppressor | partially of eye photoreceptor cell | adult stage | decreased number phenotype of Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A}

(Sheng et al., 2025)

bsk^HMS00777/Scer\GAL4^GMR.PU is a suppressor | partially of ommatidium | adult stage phenotype of Scer\GAL4^GMR.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A}

(Sheng et al., 2025)

Scer\GAL4^Act.PU/bsk^HMS00777 is a suppressor of adult midgut epithelium | somatic clone phenotype of TER94^k15502

(Liu et al., 2022)

Scer\GAL4^Act.PU/bsk^HMS00777 is a suppressor of adult midgut epithelium | somatic clone phenotype of Der-1^Δ

(Liu et al., 2022)

Scer\GAL4^Act.PU/bsk^HMS00777 is a suppressor of adult midgut epithelium | somatic clone phenotype of Der-1^SH1964

(Liu et al., 2022)

bsk^HMS00777/Scer\GAL4^NP5130 is a suppressor of adult midgut progenitor cell | increased number phenotype of Scer\GAL4^NP5130, TER94^GL00448

(Liu et al., 2022)

bsk^HMS00777/Scer\GAL4^NP5130 is a suppressor of adult midgut progenitor cell | increased number phenotype of Scer\GAL4^NP5130, TER94^HMS00656

(Liu et al., 2022)

bsk^HMS00777, Scer\GAL4^byn-Gal4 is a suppressor | partially of adult hindgut phenotype of Ras85D^V12.UAS, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

bsk^HMS00777, Scer\GAL4^byn-Gal4 is a suppressor | partially of adult abdomen phenotype of Ras85D^V12.UAS, Scer\GAL4^byn-Gal4

(Bangi et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of bsk^HMS00777 partially suppresses the dissemination of hindgut cells seen in flies expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^byn-Gal4.

(Bangi et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

32977

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00777}attP2

NIG-Fly

HMS00777

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00777}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

JNK^RNAi

(Chen et al., 2020)

bsk^HMS00777

bsk^RNAi

(Zhao et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections