FlyBase Allele Report: Dmel\foxo[HMS00793]

General Information

Symbol

Dmel\foxo^HMS00793

Species

D. melanogaster

Name

FlyBase ID

FBal0257474

Feature type

allele

Associated gene

Dmel\foxo

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00793}

Also Known As

UAS-Foxo RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00793}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00793

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Parkinson's disease

CEA

(Tas et al., 2018)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4²²¹

(Iyer et al., 2013)

abnormal neuroanatomy, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

decreased cell number | adult stage, with Scer\GAL4^GMR58E02

(Tas et al., 2018)

Phenotype Manifest In

abdominal anterior ventral multidendritic neuron vdaa, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

adult dopaminergic PAM neuron | adult stage, with Scer\GAL4^GMR58E02

(Tas et al., 2018)

larval dorsal multidendritic neuron ddaC, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

larval dorsal multidendritic neuron ddaD, with Scer\GAL4²²¹

(Iyer et al., 2013)

Detailed Description

Statement

Reference

The expression of foxo^HMS00793 under the control of Scer\GAL4^GMR58E02 leads to a significant decrease in the number of dopaminergic PAM neurons in the adult brain, as compared to controls; adulthood-only expression under the control of Scer\GAL4^Fer2.2359 (and Gal80[ts], for the temporal control of expression) also leads to a significant decrease in the number of dopaminergic PAM neurons in 35 days old adults, but not in 1 and 14 days old adults, as compared to controls.

(Tas et al., 2018)

Expression of foxo^HMS00793 in C-I neurons under the control of Scer\GAL4²²¹ results in ddaD neurons that have an increased number of dendritic branches compared to controls.

Expression of foxo^HMS00793 in C-IV neurons under the control of Scer\GAL4^ppk.1.9 results in a reduction in total dendritic length in ddaC and v'ada neurons. The total number of dendritic branches is also reduced in ddaC neurons.

(Iyer et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

foxo^HMS00793/Scer\GAL4^Cg.PU is a non-enhancer of increased size phenotype of Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A}

(Sheng et al., 2025)

NOT Suppressor of

Statement

Reference

foxo^HMS00793/Scer\GAL4^Cg.PU is a non-suppressor of increased size phenotype of Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A}

(Sheng et al., 2025)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

foxo^HMS00793/Scer\GAL4^Cg.PU is a non-enhancer of lipid droplet phenotype of Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A}

(Sheng et al., 2025)

NOT Suppressor of

Statement

Reference

foxo^HMS00793/Scer\GAL4^Cg.PU is a non-suppressor of lipid droplet phenotype of Scer\GAL4^Cg.PU, babo^{RNAi.circbabo(5,6,7,8S).UAS.A}

(Sheng et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

32993

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00793}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

foxo^HMS00793

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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