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General Information
Symbol
Dmel\SREBP189
Species
D. melanogaster
Name
FlyBase ID
FBal0241326
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dSREBP189, dSREP189
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

Deletion extends from site of P{SUPor-P}Gyc76CKG03723 insertion within Gyc76C to amino acid 233 of HLH106. The deletion removes 697 nucleotides of the HLH106 ORF and the first noncoding exon of Gyc76C.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the progenitor insertion has resulted in a deletion which affects both Gyc76C and HLH106 (neighbouring genes). The deletion extends 697bp into the HLH106 open reading frame, up to amino acid residue 233 in exon 3 (the next in-frame start codon is at amino acid residue 265). The deletion also removes the predicted first exon of Gyc76C.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

HLH106189 mutants survive extremely poorly on unsupplemented medium, and their survival is much improved on medium supplemented with fatty acids.

In HLH106189 mutant flies, lethality is reduced by supplementing food with fatty acids.

Homozygous larvae show a profound defects in growth during the second larval instar.

HLH10652/HLH106189 first instar larvae contain significantly less total fatty acid than wild-type controls, but the relative abundance of various fatty acid species does not differ significantly from that of controls.

The survival of homozygotes to adulthood is markedly improved in the presence of soy lipids (lecithin) in the food medium, and increases with increasing concentration of soy lipid (up to 9%). The rescued adults are indistinguishable in mass from their heterozygous siblings and are morphologically normal.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
NOT Suppressor of
Statement
Reference

SREBP[+]/SREBP189 is a non-suppressor of abnormal neuroanatomy | somatic clone | adult stage | progressive | conditional phenotype of Pectomb593

HLH106[+]/SREBP189, SREBPD386A/SREBPD386A is a non-suppressor of viable | conditional phenotype of S2PKG08356/S2P1

Phenotype Manifest In
NOT Suppressor of
Statement
Reference

SREBP[+]/SREBP189 is a non-suppressor of axon | somatic clone | adult stage | progressive | conditional phenotype of Pectomb593

SREBP[+]/SREBP189 is a non-suppressor of eye photoreceptor cell | somatic clone | adult stage | progressive | conditional phenotype of Pectomb593

SREBP[+]/SREBP189 is a non-suppressor of optic cartridge | somatic clone | adult stage | progressive | conditional phenotype of Pectomb593

Additional Comments
Genetic Interactions
Statement
Reference

A SREBP189 heterozygous background is sufficient to ameliorate the lipid droplet accumulation displayed in sicilyE mutants.

A SREBP189 heterozygous background is sufficient to ameliorate the lipid droplet accumulation displayed in Aats-metFB mutants.

A SREBP189 heterozygous background is sufficient to ameliorate the lipid droplet accumulation displayed in MarfB mutants.

On unsupplemented medium, S2PKG08356/S2P1 mutants in the presence of two copies of HLH106D386A and carrying HLH106189/+, survive at less than 25% of the expected rate. When these animals are homozygous for HLH106189, survival at only 10% of the expected rate is observed. Survival is restored by supplementing the culture medium with free fatty acids.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (5)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (10)