FlyBase Allele Report: Dmel\S2P[1]

General Information

Symbol

Dmel\S2P¹

Species

D. melanogaster

Name

FlyBase ID

FBal0244688

Feature type

allele

Associated gene

Dmel\S2P

Associated Insertion(s)

Carried in Construct

Also Known As

dS2P¹

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Matthews et al., 2009)

Progenitor genotype

P{EP}Sln^EP2245

(Matthews et al., 2009)

Cytology

Description

Imprecise excision of the progenitor insertion resulting in a deletion which encompasses the entire S2P locus and neighbouring CG34229.

(Matthews et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased body size (with S2P^KG08356)

(Matthews et al., 2009)

lethal - all die before end of larval stage (with S2P^KG08356)

(Amarneh et al., 2009)

some die during larval stage (with S2P^KG08356)

(Amarneh et al., 2009)

viable

(Casso et al., 2012)

viable | conditional

(Matthews et al., 2009)

viable | conditional (with S2P^KG08356)

(Amarneh et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

Viability is reduced in S2P^KG08356/S2P¹ mutant flies from S2P^KG08356/S2P^KG08356 homozygous mothers mated to S2P¹ males. Viability is restored by feeding the flies medium enriched with fatty acids.

(Amarneh et al., 2009)

S2P^KG08356/S2P¹ larvae are comparable in size to control larvae 48 hours after egg laying. However, from this age mutant larvae are distinctly smaller than control larvae, and emerge on average 2 days late (or even later if animals are raised in conditions of crowding). By adulthood, mutants display a greater variability in body size compared to controls. Mutants show normal morphology.

Viability is reduced in S2P^KG08356/S2P¹ mutant flies from S2P¹/S2P¹ homozygous mothers mated to S2P^KG08356 males, compared to progeny from heterozygous mutant parents. This reduced viability is restored by feeding the flies on a fatty-acid enriched culture medium.

(Matthews et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

S2P^KG08356/S2P¹ has lethal | larval stage phenotype, enhanceable by HLH106[+]/SREBP¹⁸⁹, SREBP^D386A/SREBP^D386A

(Amarneh et al., 2009)

S2P^KG08356/S2P¹ has lethal | larval stage phenotype, enhanceable by SREBP^D386A/SREBP^D386A/SREBP¹⁸⁹/SREBP¹⁸⁹

(Amarneh et al., 2009)

Suppressed by

Statement

Reference

S2P^KG08356/S2P¹ has viable | conditional phenotype, suppressible by Drice^Δ1/Ice[+]

(Amarneh et al., 2009)

S2P^KG08356/S2P¹ has viable | conditional phenotype, suppressible by Drice^Δ1/Drice^Δ1

(Amarneh et al., 2009)

S2P^KG08356/S2P¹ has viable | conditional phenotype, suppressible by Dronc⁵¹/Nc[+]

(Amarneh et al., 2009)

S2P^KG08356/S2P¹ has viable | conditional phenotype, suppressible by Dronc⁵¹/Dronc⁵¹

(Amarneh et al., 2009)

NOT suppressed by

Statement

Reference

S2P^KG08356/S2P¹ has viable | conditional phenotype, non-suppressible by HLH106[+]/SREBP¹⁸⁹, SREBP^D386A/SREBP^D386A

(Amarneh et al., 2009)

S2P^KG08356/S2P¹ has viable | conditional phenotype, non-suppressible by SREBP^D386A/SREBP^D386A/SREBP¹⁸⁹/SREBP¹⁸⁹

(Amarneh et al., 2009)

Other

Statement

Reference

SppL^24J/Df(3R)Sppl^BW1, S2P¹ has viable phenotype

(Casso et al., 2012)

SppL^24J/Df(3R)Sppl^BW1, S2P¹ has fertile phenotype

(Casso et al., 2012)

Df(3R)Sppl^BW1/SppL^57D, S2P¹ has viable phenotype

(Casso et al., 2012)

Df(3R)Sppl^BW1/SppL^57D, S2P¹ has fertile phenotype

(Casso et al., 2012)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Double mutants of S2P¹ and either SppL^24J/Df(3R)Sppl^BW1 or SppL^57D/Df(3R)Sppl^BW1 are viable, of normal size and shape, and fertile.

(Casso et al., 2012)

S2P^KG08356/S2P¹, Ice^Δ1/+ and S2P^KG08356/S2P¹, Ice^Δ1/Ice^Δ1 mutant larvae exhibit lethality between second and third instar stages. Lethality is rescued partially by supplementing fly food with fatty acids, but viability is still reduced compared to S2P^KG08356/S2P¹ mutants.

S2P^KG08356/S2P¹, Nc⁵¹/+ and S2P^KG08356/S2P¹, Nc⁵¹/Nc⁵¹ mutant larvae exhibit lethality between second and third instar stages. Lethality is rescued partially by supplementing fly food with fatty acids, but viability is still reduced compared to S2P^KG08356/S2P¹ mutants.

On unsupplemented medium, S2P^KG08356/S2P¹ mutants in the presence of two copies of HLH106^D386A and carrying HLH106¹⁸⁹/+, survive at less than 25% of the expected rate. When these animals are homozygous for HLH106¹⁸⁹, survival at only 10% of the expected rate is observed. Survival is restored by supplementing the culture medium with free fatty acids.

(Amarneh et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

38392

w^*; S2P¹/CyO, P{ActGFP}JMR1; SREBP¹⁸⁹/TM6B, Tb⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

S2P¹

(Casso et al., 2012)

dS2P¹

(Amarneh et al., 2009, Matthews et al., 2009)

ds2p¹

(Matthews et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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