FB2026_02 , released June 18, 2026
Allele: Dmel\SppL24J
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General Information
Symbol
Dmel\SppL24J
Species
D. melanogaster
Name
FlyBase ID
FBal0267946
Feature type
allele
Associated gene
Dmel\SppL
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Casso et al., 2012)
Progenitor genotype
P{lacW}SppLSH116
(Casso et al., 2012)
Cytology
Description

Imprecise excision of P{lacW}SpplSH116 resulting in elimination of the branch points for the introns between non-coding exons 2-3 and between non-coding exon 2 and coding exon 1 (proximal to the insertion), and removal of the translation start site, the first transmembrane domain and part of the loop between transmembrane domains 1 and 2 (distal to the insertion).

(Casso et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants display no obvious morphological abnormalities. Hemizygous SppL24J/Df(3R)SpplBW1 flies have a similar life span to controls.

      (Casso et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      SppL24J/Df(3R)SpplBW1 is a non-enhancer of lethal | larval stage phenotype of Df(2L)lwr14/Spp5

      (Casso et al., 2012)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Removal of SppL (using the genotype SppL24J/Df(3R)SpplBW1) in a Spp5/+ or Df(2L)lwr14, lwr+t2.4/+ background has no noticeable effect on viability, morphology or fertility.

      Lethality of Spp5/Df(2L)lwr14, lwr+t2.4; SppL24J/Df(3R)SpplBW1 double mutants occurs during larval stages, as it does in the Spp single mutant. Removal of SppL does not enhance the Spp tracheal phenotype.

      Double mutants of S2P1 and SppL24J/Df(3R)SpplBW1 are viable, of normal size and shape, and fertile.

      (Casso et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      SppL24J
      Sppl24J
      sppL24J
      (Casso et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)