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General Information
Symbol
Dmel\SREBP52
Species
D. melanogaster
Name
FlyBase ID
FBal0147883
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dSREBP52
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion 3bp into exon 1.

PBac{GAL4D,EYFP} insertion in an exon of HLH106. The insertion site is at position 16226 of accession number AE003515.2.

Insertion components
PBac{GAL4D,EYFP}SREBP52
Product class / Tool use(s)
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

HLH10652/HLH106189 first instar larvae contain significantly less total fatty acid than wild-type controls, but the relative abundance of various fatty acid species does not differ significantly from that of controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference

SREBP52/HLH106[+] is a suppressor of adult heart phenotype of eas2

Additional Comments
Genetic Interactions
Statement
Reference

The increased whole fly triglyceride levels seen in 1 week old eas2 females are suppressed if they are also carrying HLH10652/+.

HLH10652/+ rescues the increased heartbeat rate and constricted heart phenotypes of eas2 flies.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Separable from: an unrelated pupal lethal mutation on the same chromosome.

Comments
Comments

Excision of the PBac{GAL4D,EYFP} element can revert the lethal phenotype.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (4)