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Citation
Meltzer, S., Bagley, J.A., Perez, G.L., O'Brien, C.E., DeVault, L., Guo, Y., Jan, L.Y., Jan, Y.N. (2017). Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons.  Cell Rep. 21(4): 859--866.
FlyBase ID
FBrf0237004
Publication Type
Research paper
Abstract

Disruptions in lipid homeostasis have been observed in many neurodevelopmental disorders that are associated with dendrite morphogenesis defects. However, the molecular mechanisms of how lipid homeostasis affects dendrite morphogenesis are unclear. We find that easily shocked (eas), which encodes a kinase with a critical role in phospholipid phosphatidylethanolamine (PE) synthesis, and two other enzymes in this synthesis pathway are required cell autonomously in sensory neurons for dendrite growth and stability. Furthermore, we show that the level of Sterol Regulatory Element-Binding Protein (SREBP) activity is important for dendrite development. SREBP activity increases in eas mutants, and decreasing the level of SREBP and its transcriptional targets in eas mutants largely suppresses the dendrite growth defects. Furthermore, reducing Ca(2+) influx in neurons of eas mutants ameliorates the dendrite morphogenesis defects. Our study uncovers a role for EAS kinase and reveals the in vivo function of phospholipid homeostasis in dendrite morphogenesis.

Graphical Abstract
Obtained with permission from Cell Press.
PubMed ID
PubMed Central ID
PMC5687885 (PMC) (EuropePMC)
Related Publication(s)
Review

Neuronal Fat and Dendrite Morphogenesis: The Goldilocks Effect.
Sundararajan and Miller, 2018, Trends Neurosci. 41(5): 250--252 [FBrf0238769]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell Rep.
    Title
    Cell reports
    ISBN/ISSN
    2211-1247
    Data From Reference