FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\easUAS.cPa
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General Information
Symbol
Dmel\easUAS.cPa
Species
D. melanogaster
Name
FlyBase ID
FBal0180036
Feature type
allele
Associated gene
Dmel\eas
Associated Insertion(s)
Carried in Construct
P{UAS-eas.P}
Also Known As
UAS-eas+
Key Links
Transgenic product class
wild_type
(Pascual et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Pascual et al., 2005)
Mutagen
in vitro construct
(Pascual et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-eas.P}
Cytology
Description

UAS sequences drive expression of eas.

(Pascual et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
eas
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of easScer\UAS.cPa under the simultaneous control of both Scer\GAL4tin.cBa and Scer\GAL4Scer\UAS.cHa improves heart performance under stress compared to control flies.

      (Lim et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4HCH.Hand/easUAS.cPa rescues eas2

      (Lim et al., 2011)
      Partially rescues

      Scer\GAL4ey-OK107/easUAS.cPa partially rescues easalaE13

      (Pascual et al., 2005)
      Comments

      Expression of easScer\UAS.cPa under the control of Scer\GAL4HCH.Hand significantly normalises the heart period of eas2 mutant adults, mainly by restoring the diastolic interval to normal levels. In addition, the cardiac chamber appears normal in size in the rescued animals.

      Expression of easScer\UAS.cPa under the control of Scer\GAL4HCH.Hand rescues the stress-induced heart failure rates of eas2 adult hearts to normal levels.

      (Lim et al., 2011)

      The majority of flies have brains of wild-type appearance when easScer\UAS.cPa is expressed under the control of Scer\GAL4OK107 in a easalaE13 background.

      (Pascual et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      easScer\UAS.cPa
      easUAS.cPa
      Name Synonyms
      Secondary FlyBase IDs
        References (4)