FlyBase Allele Report: Dmel\Hnf4[HMC05862]

General Information

Symbol

Dmel\Hnf4^HMC05862

Species

D. melanogaster

Name

FlyBase ID

FBal0322131

Feature type

allele

Associated gene

Dmel\Hnf4

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC05862}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HMC05862}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC05862

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal courtship behavior, with Scer\GAL4^Desat1.PB

(Sun et al., 2023)

decreased cell number | oogenesis, with Scer\GAL4^{VP16.nanos.UTR}

(Amartuvshin et al., 2025)

visible | adult stage, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

Phenotype Manifest In

adult midgut region R2, with Scer\GAL4^{Mal-A7-MI00819-TG4.2}

(Vonolfen et al., 2024)

adult midgut region R2, with Scer\GAL4^pHCl-2.PR

(Vonolfen et al., 2024)

adult midgut region R2 | nutrition conditional, with Scer\GAL4^mex1.2.1

(Vonolfen et al., 2024)

adult midgut region R3, with Scer\GAL4^Desat1.PB

(Vonolfen et al., 2024)

adult midgut region R3, with Scer\GAL4^mex1.2.1

(Vonolfen et al., 2024)

adult midgut region R3, with Scer\GAL4^pHCl-2.PR

(Vonolfen et al., 2024)

adult midgut region R4, with Scer\GAL4^{Mal-A7-MI00819-TG4.2}

(Vonolfen et al., 2024)

adult midgut region R4 | nutrition conditional, with Scer\GAL4^mex1.2.1

(Vonolfen et al., 2024)

adult midgut region R5, with Scer\GAL4^cad.PU

(Vonolfen et al., 2024)

adult midgut region R5, with Scer\GAL4^Desat1.PB

(Vonolfen et al., 2024)

adult midgut region R5, with Scer\GAL4^mex1.2.1

(Vonolfen et al., 2024)

eye, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

female germline stem cell | decreased number, with Scer\GAL4^{VP16.nanos.UTR}

(Amartuvshin et al., 2025)

lipid droplet | adult stage, with Scer\GAL4^cad.PU

(Vonolfen et al., 2024)

lipid droplet | adult stage, with Scer\GAL4^Desat1.PB

(Vonolfen et al., 2024)

lipid droplet | adult stage, with Scer\GAL4^{Mal-A7-MI00819-TG4.2}

(Vonolfen et al., 2024)

lipid droplet | adult stage, with Scer\GAL4^mex1.2.1

(Vonolfen et al., 2024)

lipid droplet | adult stage, with Scer\GAL4^pHCl-2.PR

(Vonolfen et al., 2024)

Detailed Description

Statement

Reference

Expression under the control of Scer\GAL4^eya.enh1+E+2 results in a rough eye phenotype.

(Pletcher et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hnf4^HMC05862, Scer\GAL4^{VP16.nanos.UTR} is a suppressor of decreased cell number | oogenesis phenotype of Acc^HMS01230, Scer\GAL4^{VP16.nanos.UTR}

(Amartuvshin et al., 2025)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hnf4^HMC05862, Scer\GAL4^{VP16.nanos.UTR} is a suppressor of female fusome phenotype of Acc^HMS01230, Scer\GAL4^{VP16.nanos.UTR}

(Amartuvshin et al., 2025)

Hnf4^HMC05862, Scer\GAL4^{VP16.nanos.UTR} is a suppressor of female germline cyst phenotype of Acc^HMS01230, Scer\GAL4^{VP16.nanos.UTR}

(Amartuvshin et al., 2025)

Hnf4^HMC05862, Scer\GAL4^{VP16.nanos.UTR} is a suppressor of female germline stem cell | decreased number phenotype of Acc^HMS01230, Scer\GAL4^{VP16.nanos.UTR}

(Amartuvshin et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

64988

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05862}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hnf4^HMC05862

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections