FlyBase Allele Report: Dmel\cPges[KO]

General Information

Symbol

Dmel\cPges^KO

Species

D. melanogaster

Name

FlyBase ID

FBal0408809

Feature type

allele

Associated gene

Dmel\cPges

Associated Insertion(s)

TI{TI}cPges^KO

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Fujinaga et al., 2025)

Mutagen

CRISPR/Cas9

(Fujinaga et al., 2025)

gene targeting by homologous recombination

(Fujinaga et al., 2025)

Progenitor genotype

Associated Insertion(s)

TI{TI}cPges^KO

Cytology

Description

1326bp deletion that removes the entire cPges coding sequence. A Disc\RFP^3xP3.cUa marker has been inserted in place of the deleted sequence.

(Fujinaga et al., 2025)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

cPges^KO has lethal - all die before end of P-stage | recessive phenotype, suppressible by Hsap\PTGES3^UAS.cFa/Scer\GAL4^αTub84B.PL

(Fujinaga et al., 2025)

cPges^KO has lethal - all die before end of P-stage | recessive phenotype, suppressible by Hsap\PTGES3^UAS.cFa/Scer\GAL4^MsrA.657

(Fujinaga et al., 2025)

cPges^KO has lethal - all die before end of P-stage | recessive phenotype, suppressible by Scer\GAL4^{Pgr-CR01668-TG4.2}/Hsap\PTGES3^UAS.cFa

(Fujinaga et al., 2025)

cPges^KO has lethal - all die before end of P-stage | recessive phenotype, suppressible by Hsap\PTGES3^UAS.cFa/Scer\GAL4^btl.PS

(Fujinaga et al., 2025)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

cPges^KO is rescued by Scer\GAL4^{Pgr-CR01668-TG4.2}/cPges^{UAS.Tag:FLAG,Tag:HA}

(Fujinaga et al., 2025)

cPges^KO is rescued by cPges^{UAS.Tag:FLAG,Tag:HA}/Scer\GAL4^btl.PS

(Fujinaga et al., 2025)

cPges^KO is rescued by cPges^{UAS.Tag:FLAG,Tag:HA}/Scer\GAL4^MsrA.657

(Fujinaga et al., 2025)

cPges^KO is rescued by cPges^{UAS.Tag:FLAG,Tag:HA}/Scer\GAL4^αTub84B.PL

(Fujinaga et al., 2025)

Not rescued by

cPges^KO is not rescued by cPges^{UAS.Tag:FLAG,Tag:HA}/Scer\GAL4^bs.Term

(Fujinaga et al., 2025)

cPges^KO is not rescued by cPges^{UAS.Tag:FLAG,Tag:HA}/Scer\GAL4^Desat1.PB

(Fujinaga et al., 2025)

cPges^KO is not rescued by Scer\GAL4^elav.PU/cPges^{UAS.Tag:FLAG,Tag:HA}

(Fujinaga et al., 2025)

cPges^KO is not rescued by Scer\GAL4^nSyb.PP/cPges^{UAS.Tag:FLAG,Tag:HA}

(Fujinaga et al., 2025)

cPges^KO is not rescued by cPges^{UAS.Tag:FLAG,Tag:HA}/Scer\GAL4^Cg.PA

(Fujinaga et al., 2025)

cPges^KO is not rescued by cPges^{UAS.Tag:FLAG,Tag:HA}/Scer\GAL4^He.PZ

(Fujinaga et al., 2025)

cPges^KO is not rescued by Scer\GAL4^Myo31DF.PU/cPges^{UAS.Tag:FLAG,Tag:HA}

(Fujinaga et al., 2025)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

cPges^KO

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections