FlyBase Gene Report: Dmel\Shc

General Information

Symbol

Dmel\Shc

Species

D. melanogaster

Name

SHC-adaptor protein

Annotation Symbol

CG3715

Feature Type

protein_coding_gene

FlyBase ID

FBgn0015296

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

SHC-adaptor protein (Shc) encodes a protein involved in receptor tyrosine kinase signalling. It regulates anti-parasitoid immune response and tracheal development. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Interactive Fly

Also Known As

dshc

Key Links

Genomic Location

Cytogenetic map

67B5-67B5

Sequence location

3L:9,427,010..9,428,671 [+]

Recombination map

3-29

RefSeq locus

NT_037436 REGION:9427010..9428671

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (20 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables epidermal growth factor receptor binding

inferred from direct assay

(Li et al., 1996, Lai et al., 1995)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables receptor tyrosine kinase binding

inferred from biological aspect of ancestor with PANTHER:PTN000818658

(GO Reference Genome Project, 2011-)

Biological Process (17 terms)

Terms Based on Experimental Evidence (15 terms)

CV Term

Evidence

References

involved_in border follicle cell migration

inferred from mutant phenotype

(Bianco et al., 2007)

involved_in compound eye photoreceptor cell differentiation

inferred from mutant phenotype

(Luschnig et al., 2000)

involved_in dorsal/ventral axis specification, ovarian follicular epithelium

inferred from mutant phenotype

(Luschnig et al., 2000)

involved_in epidermal growth factor receptor signaling pathway

inferred from mutant phenotype

(Bianco et al., 2007)

inferred from direct assay

(Li et al., 1996, Lai et al., 1995)

inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731

(Luschnig et al., 2000)

involved_in epithelial cell migration, open tracheal system

inferred from mutant phenotype

(Cabernard and Affolter, 2005)

involved_in fibroblast growth factor receptor signaling pathway

inferred from mutant phenotype

(Cabernard and Affolter, 2005, Wilson et al., 2005)

involved_in imaginal disc-derived wing vein specification

inferred from mutant phenotype

(Luschnig et al., 2000)

involved_in melanotic encapsulation of foreign target

inferred from mutant phenotype

(Howell et al., 2012)

involved_in mesodermal cell migration

inferred from mutant phenotype

(Wilson et al., 2005)

involved_in positive regulation of TORC1 signaling

inferred from mutant phenotype

(Tran et al., 2013)

involved_in regulation of dorsal/ventral axon guidance

inferred from mutant phenotype

(Luschnig et al., 2000)

involved_in terminal region determination

inferred from mutant phenotype

(Luschnig et al., 2000)

involved_in torso signaling pathway

inferred from genetic interaction with FLYBASE:tor; FB:FBgn0003733

(Luschnig et al., 2000)

involved_in tracheal outgrowth, open tracheal system

inferred from mutant phenotype

(Cabernard and Affolter, 2005)

involved_in vascular endothelial growth factor receptor signaling pathway

inferred from mutant phenotype

(Tran et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in cell surface receptor protein tyrosine kinase signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000818658

(GO Reference Genome Project, 2011-)

involved_in intracellular signal transduction

inferred from electronic annotation with InterPro:IPR006019

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000818658

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Pathway (FlyBase)

TORSO SIGNALING PATHWAY CORE COMPONENTS

EGFR SIGNALING PATHWAY CORE COMPONENTS

FGFR SIGNALING PATHWAY CORE COMPONENTS

PVR SIGNALING PATHWAY CORE COMPONENTS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

SHC-adaptor protein (Shc) encodes a protein involved in receptor tyrosine kinase signalling. It regulates anti-parasitoid immune response and tracheal development. [Date last reviewed: 2019-03-14]

Pathway (FlyBase)

TORSO SIGNALING PATHWAY CORE COMPONENTS -: The formation of Drosophila embryonic termini is controlled by the localized activation of Torso (tor) receptor tyrosine kinase. The Torso signaling pathway acts via the canonical Ras/Raf/MAP kinase cascade. (Adapted from FBrf0157176.)
EGFR SIGNALING PATHWAY CORE COMPONENTS -: The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).
FGFR SIGNALING PATHWAY CORE COMPONENTS -: Fibroblast Growth Factor Receptor (FGFR) signaling pathway is initiated by the binding of secreted FGFs - bnl or ths/pyr to receptor tyrosine kinases btl or htl, respectively, to initiate signaling primarily via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0221038).
PVR SIGNALING PATHWAY CORE COMPONENTS -: PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).

Summary (Interactive Fly)

phosphotyrosine-binding domain protein - interacts with and regulates Torso and Egfr signaling conferring specificity to receptor function

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Shc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V3C8)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Shc-RA

FBtr0076458

NM_079944

1600

409

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Shc-PA

FBpp0076186

45.0

409

6.51

Q9V3C8

NP_524683

AAF50273

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Shc using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Shc_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.44

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Shc in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Shc

View exonic expression by tissue for Dmel\Shc

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015296

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44052/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015296

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015296

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015296

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3715

Flygut - An atlas of the Drosophila adult midgut

FBgn0015296

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Shc

Transgenic constructs containing regulatory region of Shc

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3L)AC1

(Luschnig et al., 2000)

Gene not disrupted in

Df(3L)29A6

(Luschnig et al., 2000)

Inferred from location ( 1 )

Dp(3;2)GV-CH321-17F07

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | embryonic stage | germline clone | maternal effect | recessive

Shc^111-40

lethal | embryonic stage | maternal effect | recessive

partially lethal - majority die | pupal stage | recessive

partially lethal - majority die | recessive

Shc^111-40

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Shc^GD11053

viable, with Scer\GAL4^pnr-MD237

Shc^GD11053

viable, with Scer\GAL4^tin.CΔ4

Shc^GD11053

Sterility

Allele

female sterile | recessive

male sterile | recessive

Shc^111-40

Other Phenotypes

Allele

abnormal immune response | larval stage, with Scer\GAL4^Hml.PG

Shc^GD11053

abnormal planar polarity | recessive

Shc^BG

terminal phenotype | germline clone | maternal effect

Shc^111-40

visible | recessive

Shc^111-40

Phenotype manifest in

Allele

border follicle cell | somatic clone

Shc^111-40

cephalopharyngeal skeleton | germline clone | maternal effect

dorsal air sac primordium | somatic clone

Shc^BG

dorsal appendage | maternal effect

Shc^BG

egg | maternal effect

Shc^BG

egg chorion | maternal effect

Shc^BG

embryo | extended germ band stage | germline clone | maternal effect

embryo | germline clone | maternal effect

Shc^111-40

embryonic/first instar larval cuticle | germline clone | maternal effect

embryonic abdominal segment 8 | germline clone | maternal effect

eye

Shc^111-40

eye | anterior | maternal effect

Shc^BG

eye | maternal effect

Shc^BG

eye photoreceptor cell | maternal effect

Shc^BG

filzkorper | germline clone | maternal effect

Malpighian tubule | germline clone | maternal effect

mesoderm | germline clone

Shc^13G

ommatidium

Shc^111-40

ommatidium | maternal effect

Shc^BG

ovary | maternal effect

Shc^BG

ventral denticle belt | germline clone | maternal effect

wing | maternal effect

Shc^BG

wing vein L4 | distal | maternal effect

Shc^BG

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (45)

Hsap\SHC1

13 of 14

Yes

Hsap\SHC4

13 of 14

Yes

Hsap\SHC3

12 of 14

Yes

Hsap\SHC2

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\APBB2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (35)

Rnor\Shc1

13 of 14

Yes

Rnor\Shc4

13 of 14

Yes

Rnor\Shc2

12 of 14

Yes

Rnor\Shc3

12 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (34)

Mmus\Shc1

13 of 14

Yes

Mmus\Shc4

12 of 14

Yes

Mmus\Shc2

11 of 14

Yes

Mmus\Shc3

11 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Vav1

1 of 14

Mmus\Vav2

1 of 14

Mmus\Vav3

1 of 14

Xenopus tropicalis (Western clawed frog) (33)

Xtro\shc4

11 of 13

Yes

Xtro\shc2

10 of 13

Yes

Xtro\shc1

9 of 13

Yes

Xtro\klhl21

6 of 13

Yes

Xtro\shc3

6 of 13

Yes

Xtro\oma1

5 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\fer

1 of 13

Xtro\fes

1 of 13

Xtro\grb7

1 of 13

Yes

Xtro\ldlrap1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (45)

Drer\shc1

13 of 14

Yes

Drer\shc2

11 of 14

Yes

Drer\shc3

8 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\hsh2d

1 of 14

Yes

Drer\lcp2b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (16)

Cele\shc-1

10 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\frk-1

1 of 14

Cele\jip-1

1 of 14

Cele\K11E4.2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (14)

Agam\AgaP_AGAP011463

12 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Shc. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (17)

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Csk

1 of 13

csw

1 of 13

Dab

1 of 13

dock

1 of 13

hwt

1 of 13

Lnk

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SHC1; SHC adaptor protein 1

13 of 14

600560

SHC4; SHC adaptor protein 4

13 of 14

617372

SHC3; SHC adaptor protein 3

12 of 14

605263

SHC2; SHC adaptor protein 2

11 of 14

605217

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Shc - CG11723

two hybrid

(Hu et al., 2017.6.13)

Shc - CG1233

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Shc - CG7668

experimental knowledge based

(Guruharsha et al., 2011)

Shc - Egfr

pull down, western blot, two hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, anti tag western blot

(Bianco et al., 2007, van der Geer et al., 1996, Lai et al., 1995)

Shc - Pvr

experimental knowledge based, anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(Guruharsha et al., 2011, Bianco et al., 2007, Ishimaru et al., 2004)

Shc - Tmep

experimental knowledge based

(Guruharsha et al., 2011)

Shc - dos

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Shc - drk

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Shc - sty

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

btl::Egfr

suppressible

Shc

(Luschnig et al., 2000)

Egfr

suppressible

Shc

(Luschnig et al., 2000)

tor

suppressible

Shc

(Luschnig et al., 2000)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68802

DroID - A comprehensive database of gene and protein interactions.

FBgn0015296

MIST (protein-protein) - An integrated Molecular Interaction Database

44052

Pathways

Signaling Pathways (FlyBase)

TORSO SIGNALING PATHWAY CORE COMPONENTS
EGFR SIGNALING PATHWAY CORE COMPONENTS
FGFR SIGNALING PATHWAY CORE COMPONENTS
PVR SIGNALING PATHWAY CORE COMPONENTS

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MAPK signaling pathway - fly

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q24080

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-29

Cytogenetic map

67B5-67B5

Sequence location

3L:9,427,010..9,428,671 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

67B5-67B5

Limits computationally determined from genome sequence between P{EP}Hsp26^EP3336&P{EP}Hsp26^EP3315 and P{PZ}fry⁰²²⁴⁰

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

67B-67C

(Luschnig et al., 2004, Lai, 1995.5.5)

67B-67C

(determined by in situ hybridisation)

(Lai et al., 1995)

Experimentally Determined Recombination Data

Location

3-29

(FlyBase, 2016)

3-23.0

(Comeron et al., 2012)

(Lai, 1995.5.5)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

93762

w^*; Shc^KO/TM3, Sb¹

92542

y¹ v¹; P{U6.2-Shc.dgRNA}attP40/CyO

14051

y¹ w^67c23; P{SUPor-P}Shc^KG06847 ry⁵⁰⁶

83504

y¹ sc^* v¹ sev²¹; P{TKO.GS04224}attP40

66961

y¹ sc^* v¹ sev²¹; P{TRiP.HMS05427}attP40

3715R-1

3715R-2

v103906

v40464

w¹¹¹⁸ P{GD11053}v40464

v318787

PBac{fTRG01180.sfGFP-TVPTBF}VK00002

Genomic Clones (29)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (34)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RH57813

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0015296

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0015296

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Lai et al., 1995)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Shc is required for signaling by a subset of receptor tyrosine kinases; tor and Egfr, but not sev.

(Luschnig et al., 2000)

The PTB domain (phosphotyrosine binding domain) possesses a binding specificity for tyrosine-phosphorylated peptides that is optimally suited for recognition of the activated Egfr receptor.

(Li et al., 1996)

Isolated from a Drosophila cDNA expression library, using an antibody to the human Shc adaptor protein. Immunoprecipitation of protein lysates from flies expressing the activated Egfr::tor^{t4021E.hs.sev} receptor indicates that Shc is associated with the Egfr::tor^{t4021E.hs.sev} protein in vivo.

(Lai et al., 1995)

A Shc cDNA has been cloned and sequenced, and its expression pattern has been analysed.

(Lai et al., 1995)

Relationship to Other Genes

Source for database merge of

Source for merge of: Shc CG3715

(Bayraktaroglu, 2000.4.13)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG3715

(Trivedi et al., 2020, Balakrishnan et al., 2015, Howell et al., 2012, Keleman et al., 2009.8.5, Perkins et al., 2009)

D-Shc

(Moghal and Sternberg, 1999)

DSHC

(Das and Arur, 2017, Roche, 2000)

dShc

(Chien et al., 1998, Bonfini et al., 1996, Li et al., 1996, van der Geer et al., 1996, van der Geer et al., 1995)

dshc

(Cabernard and Affolter, 2005, Wilson et al., 2005, Luschnig et al., 2004, Luschnig et al., 2004, Settle et al., 2003, Cho et al., 2002, Madhani, 2001, Luschnig et al., 2000, Lai et al., 1995)

shc

(Brumby et al., 2004, Lai, 1995.5.5)

Name Synonyms

SHC adaptor protein

(Malartre, 2016)

SHC-adaptor protein

Secondary FlyBase IDs

FBgn0035990

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 64 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

44052

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V3C8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V3C8

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015296

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44052/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015296

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015296

FlyMine - An integrated database for Drosophila genomics

FBgn0015296

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3715

MARRVEL_MODEL - MARRVEL (model organism gene)

44052

Linkouts

BioGRID - A database of protein and genetic interactions.

68802

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0015296

DroID - A comprehensive database of gene and protein interactions.

FBgn0015296

DRSC - Results frm RNAi screens

FBgn0015296

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Shc_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015296

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0015296

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3715

Flygut - An atlas of the Drosophila adult midgut

FBgn0015296

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0015296

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC010804

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MAPK signaling pathway - fly

MIST (protein-protein) - An integrated Molecular Interaction Database

44052

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q24080

References (84)

The following external sites may use different assemblies or annotations than FlyBase.

1.44

Report Sections