FlyBase Gene Report: Dmel\numb

Hsap\NUMB

(Toriya et al., 2006)

Mmus\Numbl

(Zhong et al., 1997)

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, anti tag western blot

(Shan et al., 2018)

numb - AP-1γ

anti tag coimmunoprecipitation, western blot

(Cotton et al., 2013)

numb - AP-2α

pull down, autoradiography, anti tag coimmunoprecipitation, western blot, anti tag western blot, anti bait coimmunoprecipitation

(Cotton et al., 2013, Song and Lu, 2012, Wirtz-Peitz et al., 2008, Bhalerao et al., 2005, Berdnik et al., 2002)

numb - CRMP

anti tag coimmunoprecipitation, anti tag western blot

(Jauffred et al., 2013)

numb - Dap160

anti tag coimmunoprecipitation, anti tag western blot

(Tang et al., 2005)

numb - Dronc

(Ouyang et al., 2011)

numb - Eps-15

two hybrid, pull down, western blot

(Tang et al., 2005)

numb - N

two hybrid, pull down, autoradiography

(Guo et al., 1996)

numb - Nak

fluorescence polarization spectroscopy, predetermined participant, cosedimentation, molecular weight, two hybrid, pull down, molecular weight estimation by staining, nuclear magnetic resonance, autoradiography, anti tag coimmunoprecipitation, western blot

(Shan et al., 2018, Tang et al., 2005, Zwahlen et al., 2000, Chien et al., 1998, Li et al., 1998)

numb - Past1

pull down, anti tag western blot, phage display, tag visualisation

(Smith et al., 2004)

numb - aPKC

(Wirtz-Peitz et al., 2008)

numb - baz

pull down, autoradiography

(Wirtz-Peitz et al., 2008)

numb - mira

(Shen et al., 1998, Shen et al., 1997)

numb - mol

anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot, lambda phage display, fluorescence polarization spectroscopy, predetermined participant

(Qin et al., 2004)

numb - par-6

two hybrid, anti tag coimmunoprecipitation, anti tag western blot, pull down, molecular weight estimation by staining, western blot, anti bait coimmunoprecipitation, x-ray crystallography, cosedimentation, molecular weight, isothermal titration calorimetry, predetermined participant

(Wirtz-Peitz et al., 2008)

numb - pon

(Shan et al., 2018, Ouyang et al., 2011, Bhalerao et al., 2005, Lu et al., 1998)

numb - spdo

anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot

(Cotton et al., 2013, Song and Lu, 2012, Tong et al., 2010, Bhalerao et al., 2005, Hutterer and Knoblich, 2005, O'Connor-Giles and Skeath, 2003)

RNA-RNA

Physical Interaction

Assay

References

numb - mir-ban

luminiscence technology, necessary binding region

(Wu et al., 2017)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

ago

(Ouyang et al., 2011)

suppressible

(Wu et al., 2024)

enhanceable

(Komori et al., 2018)

enhanceable

brm

(Janssens et al., 2014)

enhanceable

Caf1-55

(Rajan et al., 2023)

enhanceable

(Wai et al., 1999)

suppressible

(Zhang et al., 2024)

enhanceable

Dronc

(Ouyang et al., 2011)

suppressible

Dronc

(Ouyang et al., 2011)

numb|fru

suppressible

E(spl)mγ-HLH

(Rajan et al., 2023)

enhanceable

E(z)

(Rajan et al., 2023)

enhanceable

erm

(Janssens et al., 2014)

enhanceable

fru

(Rajan et al., 2023)

enhanceable

(Wang et al., 1997)

enhanceable

insb

(Komori et al., 2018)

suppressible

insv

(Duan et al., 2011)

numb|fru

suppressible

mam

(Rajan et al., 2023)

suppressible

mam

(Rajan et al., 2023)

suppressible

(Wu et al., 2017)

enhanceable

(Janssens et al., 2014)

suppressible

(Wu et al., 2017)

suppressible

(Wu et al., 2017)

suppressible

(Ouyang et al., 2011, Guo et al., 1996)

suppressible

p53

(Ouyang et al., 2011)

suppressible

(Song and Lu, 2012, Ouyang et al., 2011, Babaoglan et al., 2009, Lundell et al., 2003, Dye et al., 1998)

enhanceable

(Babaoglan et al., 2009)

suppressible

Su(H)

(Wang et al., 1997)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

aPKC

enhanceable

(Wirtz-Peitz et al., 2008)

aPKC

suppressible

(Haenfler et al., 2012, Wirtz-Peitz et al., 2008)

aurA

suppressible

(Lee et al., 2006, Wang et al., 2006)

suppressible

(Wu et al., 2024)

enhanceable

(Komori et al., 2018)

Cdc42

suppressible

(Raymond et al., 2004)

dsh

suppressible

(Domingos et al., 2019)

enhanceable

(Bellaiche et al., 2001)

suppressible

(Nagel et al., 2000)

l(2)gl

suppressible

(Haenfler et al., 2012, Wirtz-Peitz et al., 2008)

l(2)gl

enhanceable

(Wirtz-Peitz et al., 2008, Ohshiro et al., 2000)

mts

suppressible

(Ouyang et al., 2011, Wang et al., 2009)

enhanceable

(Frise et al., 1996)

suppressible

(Han and Bodmer, 2003)

Nak

enhanceable

(Chien et al., 1998)

pbl

suppressible

(Gregory et al., 2007)

pdm2

suppressible

(Bhat and Apsel, 2004)

Pld

enhanceable

(Medina-Yáñez et al., 2020)

polo

suppressible

(Ouyang et al., 2011, Wang et al., 2007)

Prosβ6

suppressible

(Tang et al., 2005)

Rac1

suppressible

(Raymond et al., 2004)

RacGAP84C

suppressible

(Raymond et al., 2004)

RPA3

suppressible

(Zhou and Luo, 2013)

suppressible

(Babaoglan et al., 2009)

suppressible

fng|numb

(Babaoglan et al., 2009)