FlyBase Gene Report: Dmel\X11L

General Information

Symbol

Dmel\X11L

Species

D. melanogaster

Name

X11L

Annotation Symbol

CG5675

Feature Type

protein_coding_gene

FlyBase ID

FBgn0026313

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Summary

X11L (X11L) encodes a scaffolding protein that is important for eye development. It interacts with the products of rst and Appl and is required for targeting several proteins to cell membranes. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Also Known As

Mint, X11Lα, dX11L, X11, X11/Mint

Key Links

Genomic Location

Cytogenetic map

16B7-16B7

Sequence location

X:17,599,608..17,606,879 [+]

Recombination map

1-57

RefSeq locus

NC_004354 REGION:17599608..17606879

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables cell adhesion molecule binding

inferred from physical interaction with FLYBASE:rst; FB:FBgn0003285

(Vishnu et al., 2006)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in compound eye development

inferred from mutant phenotype

(Vishnu et al., 2006)

involved_in protein localization to membrane

inferred from mutant phenotype

(Gross et al., 2013)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in chemical synaptic transmission

inferred from biological aspect of ancestor with PANTHER:PTN000960968

(GO Reference Genome Project, 2011-)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

located_in axon

inferred from direct assay

(Gross et al., 2013)

located_in cytoplasm

inferred from direct assay

(Vishnu et al., 2006)

located_in Golgi apparatus

inferred from direct assay

(Gross et al., 2013)

located_in neuronal cell body

inferred from direct assay

(Gross et al., 2013)

colocalizes_with plasma membrane

inferred from direct assay

(Vishnu et al., 2006)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000960967

(GO Reference Genome Project, 2011-)

is_active_in dendritic spine

inferred from biological aspect of ancestor with PANTHER:PTN000960968

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\X11L for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry X2JE74)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

X11L-RA

FBtr0074451

NM_132996

4500

1167

X11L-RB

FBtr0301696

NM_001169310

5282

1168

X11L-RC

FBtr0333757

NM_001272725

4862

1168

X11L-RE

FBtr0340620

NM_001272726

4485

1162

X11L-RF

FBtr0340621

NM_001298447

5288

1170

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

X11L-PA

FBpp0074225

126.7

1167

4.65

FBpp0290910

126.9

1168

4.65

FBpp0305899

126.9

1168

4.65

FBpp0309484

126.2

1162

4.65

FBpp0309485

127.0

1170

4.65

X2JE74

NP_001285376

AHN59846

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1168 aa isoforms: X11L-PB, X11L-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\X11L using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.70

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12

trunk mesoderm

(Vishnu et al., 2006)

embryonic stage 14

presumptive embryonic/larval central nervous system

(Hase et al., 2002)

embryonic stage 15 -- 16

larval central nervous system

(Vishnu et al., 2006)

embryonic stage 16

larval central nervous system

(Hase et al., 2002)

embryonic stage 16 -- 17

larval ventral nerve cord

(Gross et al., 2013)

larval brain

(Gross et al., 2013)

embryo | faint | restricted

• Golgi apparatus

(Gross et al., 2013)

third instar larval stage

larval brain

(Hase et al., 2002)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 15

organism

Comment: 0-12h AEL

(Hase et al., 2002)

embryonic stage 15 -- 17

organism

Comment: 12-24h AEL

(Hase et al., 2002)

pupal stage

organism

(Hase et al., 2002)

adult stage

organism

(Hase et al., 2002)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval mushroom body

(Gross et al., 2013)

larval brain | restricted

(Gross et al., 2013)

gamma Kenyon cell | punctate

• neuronal cell body & cytoplasm & Golgi apparatus

(Gross et al., 2013)

pupal stage P6

adult optic lobe

(Vishnu et al., 2006)

eye disc

(Vishnu et al., 2006)

medulla | distal

(Vishnu et al., 2006)

primary pigment cell

(Vishnu et al., 2006)

interommatidial precursor cell

(Vishnu et al., 2006)

Additional Descriptive Data

In gamma Kenyon cells, X11L-XP has a punctate cytoplasmic expression, colocalizing with the Golgi marker, Grasp65^{Scer\UAS.T:AvicGFP-EGFP} in the neuronal cell body. X11L-XP punctae were also observed adjacent to, or possibly colocalizing with, the early endosome marker Rab5^{Scer\UAS.T:AvicGFP-EGFP}, the late endosome marker Rab7^{Scer\UAS.T:AvicGFP} and the endoplasmic reticulum marker, GgalLYZ<up>Scer\UAS.PT.T:AvicGFP-EGFP,T:UuuuKDEL.

(Gross et al., 2013)

X11L protein is expressed in pupal eye discs in the interommatidial precursor cells and most strongly in primary pigment cells in a belt next to the apical cell membranes. In pupal brains, X11L protein is localized to a distinct layer in the neuropil of the distal medulla, where is overlaps with rst expression. X11L protein shows a cytoplasmic localization in ommatidial cells.

(Vishnu et al., 2006)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in axon

inferred from direct assay

(Gross et al., 2013)

located_in cytoplasm

inferred from direct assay

(Vishnu et al., 2006)

located_in Golgi apparatus

inferred from direct assay

(Gross et al., 2013)

located_in neuronal cell body

inferred from direct assay

(Gross et al., 2013)

colocalizes_with plasma membrane

inferred from direct assay

(Vishnu et al., 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\X11L in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\X11L

View exonic expression by tissue for Dmel\X11L

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026313

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

252671/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026313

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026313

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026313

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5675

Flygut - An atlas of the Drosophila adult midgut

FBgn0026313

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 19 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of X11L

Transgenic constructs containing regulatory region of X11L

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 22 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

X11L^GD11731

viable, with Scer\GAL4^ey-OK107

X11L^RNAi.UAS.cGa

viable, with Scer\GAL4^Mef2.PR

X11L^GD11731

viable, with Scer\GAL4^pnr-MD237

X11L^GD11731

viable, with Scer\GAL4^tin.CΔ4

X11L^GD11731

Sterility

Allele

fertile

X11L^e03317

Other Phenotypes

Allele

increased cell death, with Scer\GAL4^GMR.PY

X11L^UAS.cMa

visible, with Scer\GAL4^GMR.PY

Phenotype manifest in

Allele

eye, with Scer\GAL4^GMR.PY

eye disc, with Scer\GAL4^GMR.PY

X11L^UAS.cMa

four cone-cell ommatidial precursor cluster, with Scer\GAL4^GMR.PF

X11L^RNAi.UAS

four cone-cell ommatidial precursor cluster, with Scer\GAL4^MZ1369

X11L^UAS.cMa

interommatidial bristle, with Scer\GAL4^MZ1369

X11L^UAS.cMa

lamina, with Scer\GAL4^GMR.PF

X11L^RNAi.UAS

lobe system of mushroom body, with Scer\GAL4^ey-OK107

X11L^RNAi.UAS.cGa

medulla, with Scer\GAL4^GMR.PF

X11L^RNAi.UAS

mushroom body medial lobe

X11L⁸⁰

mushroom body vertical lobe

X11L⁸⁰

ommatidial precursor cluster, with Scer\GAL4^GMR.PF

X11L^RNAi.UAS

ommatidial precursor cluster, with Scer\GAL4^MZ1369

X11L^UAS.cMa

ommatidium, with Scer\GAL4^MZ1369

X11L^UAS.cMa

primary pigment cell, with Scer\GAL4^GMR.PF

X11L^RNAi.UAS

primary pigment cell, with Scer\GAL4^MZ1369

X11L^UAS.cMa

rhabdomere, with Scer\GAL4^GMR.PF

X11L^RNAi.UAS

rhabdomere | ectopic, with Scer\GAL4^MZ1369

X11L^UAS.cMa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (56)

Hsap\APBA2

9 of 14

Yes

Hsap\APBA1

8 of 14

Yes

6 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\APBB2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (39)

Rnor\Apba2

10 of 14

Yes

Rnor\Apba1

9 of 14

Yes

6 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Tamalin

1 of 14

Rnor\Ush1c

1 of 14

Rnor\Whrn

1 of 14

Mus musculus (laboratory mouse) (40)

Mmus\Apba2

9 of 14

Yes

Mmus\Apba1

8 of 14

Yes

5 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Tamalin

1 of 14

Mmus\Ush1c

1 of 14

Mmus\Whrn

1 of 14

Xenopus tropicalis (Western clawed frog) (20)

Xtro\apba2

8 of 13

Yes

Xtro\apba1

7 of 13

Yes

Xtro\apba3

5 of 13

Yes

Xtro\adcyap1r1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ldlrap1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (49)

Drer\apba2b

10 of 14

Yes

Drer\apba1b

9 of 14

Yes

Drer\apba2a

9 of 14

Yes

Drer\apba1a

8 of 14

Yes

Drer\si:ch73-40i7.5

8 of 14

Yes

Drer\pdzd3b

2 of 14

Drer\apbb1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch211-204c21.1

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (25)

Cele\lin-10

8 of 14

Yes

Cele\C11E4.6

1 of 14

Cele\C46H11.6

1 of 14

Yes

Cele\C50F7.3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\F26E4.5

1 of 14

Cele\F28E10.4

1 of 14

Yes

Cele\F40F9.3

1 of 14

Yes

Cele\feh-1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\num-1

1 of 14

Cele\smz-1

1 of 14

Yes

Cele\smz-2

1 of 14

Yes

Cele\T19B10.5

1 of 14

Yes

Cele\txt-1

1 of 14

Yes

Cele\ZK849.1

1 of 14

Anopheles gambiae (African malaria mosquito) (37)

Agam\AgaP_AGAP000452

7 of 12

Yes

5 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP009630

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP011463

1 of 12

Agam\AgaP_AGAP012008

1 of 12

Agam\AgaP_AGAP012354

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:X11L. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (38)

9 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Aplip1

1 of 13

baz

1 of 13

bbg

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Dab

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

pyd

1 of 13

scrib

1 of 13

Shc

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

APBA2; amyloid beta precursor protein binding family A member 2

9 of 14

602712

APBA1; amyloid beta precursor protein binding family A member 1

8 of 14

602414

APBA3; amyloid beta precursor protein binding family A member 3

6 of 14

604262

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

X11L - Appl

anti bait coimmunoprecipitation, western blot, two hybrid, pull down, anti tag western blot

(Ashley et al., 2005, Hase et al., 2002)

X11L - Fas2

anti bait coimmunoprecipitation, western blot

(Ashley et al., 2005)

X11L - kirre

two hybrid

(Vishnu et al., 2006)

X11L - rst

anti tag coimmunoprecipitation, western blot, two hybrid, anti bait coimmunoprecipitation

(Vishnu et al., 2006)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

X11L

enhanceable

AP-2α

(Gross et al., 2013)

X11L

enhanceable

rst

(Vishnu et al., 2006)

X11L

enhanceable

X11Lβ

(Gross et al., 2013)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

grim

suppressible

X11L

(Gross et al., 2008)

hid

suppressible

X11L

(Gross et al., 2008)

rst

enhanceable

X11L

(Vishnu et al., 2006)

X11Lβ

enhanceable

X11L

(Gross et al., 2013)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

76144

DroID - A comprehensive database of gene and protein interactions.

FBgn0026313

MIST (protein-protein) - An integrated Molecular Interaction Database

252671

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

E1JJN6

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-57

Cytogenetic map

16B7-16B7

Sequence location

X:17,599,608..17,606,879 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

16B7-16B7

Limits computationally determined from genome sequence between P{EP}baz^EP1446 and P{EP}EP1464

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

15F-16A

(Lloyd et al., 2000)

Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.

(Lloyd et al., 2000)

Experimentally Determined Recombination Data

Location

1-57

(FlyBase, 2016)

1-58.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

29309

y¹ v¹; P{TRiP.JF02449}attP2

10678

5675R-1

5675R-3

v27479

w¹¹¹⁸; P{GD11731}v27479

v28652

w¹¹¹⁸; P{GD11731}v28652

v318247

PBac{fTRG00890.sfGFP-TVPTBF}VK00033

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (77)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD29081

Other clones

DPiM_LD29081

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0026313

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0026313

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Gross et al., 2008, Vishnu et al., 2006, Ashley et al., 2005)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Identification: as a protein that interacts with the Appl cytoplasmic domain in a yeast two-hybrid assay.

(Taru et al., 2002)

Relationship to Other Genes

Source for database merge of

Source for merge of: Mint CG5675

(FlyBase, 1996-)

Additional comments

Source for merge of Mint CG5675 was sequence comparison ( date:001203 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Mint CG5678

(Verstreken and Bellen, 2000.9.4)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (18)

Reported As

Symbol Synonym

CG5675

(Gross et al., 2013, Perkins et al., 2009, Gross et al., 2008, Legube et al., 2006, Vishnu et al., 2006, Jin et al., 2001)

CG5678

(Hase et al., 2002, Whitfield et al., 2002)

Dmint

(Humbert et al., 2003)

Dmint1

(Vishnu et al., 2006)

MINT

(Lloyd et al., 2000)

Mint

(Bowler et al., 2006, Littleton, 2000, Verstreken and Bellen, 2000.9.4)

X11

(Gross et al., 2007, Hase, 1999.11.28)

X11-like

(Gross et al., 2013)

X11/Mint

(Gross et al., 2013)

X11L

(Du et al., 2021, Pang et al., 2021, Finegan and Bergstralh, 2020, Hoi et al., 2016, Sarov et al., 2016, Bouleau and Tricoire, 2015, Mukherjee et al., 2014, Aranjuez et al., 2012, Cole et al., 2012.7.6, Japanese National Institute of Genetics, 2012.5.21, Kong et al., 2010, Kong et al., 2010, Gross et al., 2008, Nicholson et al., 2008, Cho et al., 2005)

X11Lα

(Gross et al., 2013, Tepass and Harris, 2007, Vishnu et al., 2006)

dX11

(Ashley et al., 2005)

dX11/Mint

(Cassar and Kretzschmar, 2016)

dX11L

(Hase et al., 2002, Taru et al., 2002, Yagi et al., 1999)

dX11Lα

(Liu et al., 2011)

x11/Mint

(Gross et al., 2008)

x11Lα

(Vishnu et al., 2006)

Name Synonyms

X11-like

(Hase et al., 2002)

X11/Mint

(Gross et al., 2013)

X11L

(Gross et al., 2008)

dX11/Mint/Lin-10

(Ashley et al., 2005)

Secondary FlyBase IDs

FBgn0030848
FBgn0030849

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 54 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

252671

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

X2JE74

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

X2JE74

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026313

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

252671/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026313

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026313

FlyMine - An integrated database for Drosophila genomics

FBgn0026313

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG5675

MARRVEL_MODEL - MARRVEL (model organism gene)

252671

Linkouts

BioGRID - A database of protein and genetic interactions.

76144

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0026313

DroID - A comprehensive database of gene and protein interactions.

FBgn0026313

DRSC - Results frm RNAi screens

FBgn0026313

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026313

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0026313

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5675

Flygut - An atlas of the Drosophila adult midgut

FBgn0026313

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC001711

MIST (protein-protein) - An integrated Molecular Interaction Database

252671

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

E1JJN6

References (65)

The following external sites may use different assemblies or annotations than FlyBase.

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