FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\loco
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General Information
Symbol
Dmel\loco
Species
D. melanogaster
Name
locomotion defects
Annotation Symbol
CG5248
Feature Type
protein_coding_gene
FlyBase ID
FBgn0020278
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Summary
locomotion defects (loco) encodes a regulator of G-protein signalling protein. loco product functions in neuroblast asymmetric division and blood-brain barrier formation together with G protein-coupled receptors and inhibitory G-proteins (encoded by Gαi and Gαo). It is also known that decrease of loco expression extends lifespan with stronger resistance to stressors. [Date last reviewed: 2018-10-04] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
94B6-94B8
Sequence location
Recombination map
3-75
RefSeq locus
NT_033777 REGION:22619968..22639387
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (28 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables G-protein alpha-subunit binding
inferred from physical interaction with FLYBASE:Gαi; FB:FBgn0001104
(Yu et al., 2005)
enables GDP-dissociation inhibitor activity
inferred from direct assay
(Yu et al., 2005)
enables GTPase activator activity
inferred from direct assay
(Yu et al., 2005)
enables protein binding
inferred from physical interaction with UniProtKB:P20353
(Yu et al., 2005, Granderath et al., 1999)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables GTPase activator activity
inferred from electronic annotation with InterPro:IPR046995
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000851567
(GO Reference Genome Project, 2011-)
enables GTPase regulator activity
inferred from electronic annotation with InterPro:IPR003109
(InterPro Project Members, 2004-)
Biological Process (19 terms)
Terms Based on Experimental Evidence (18 terms)
CV Term
Evidence
References
involved_in asymmetric neuroblast division
inferred from mutant phenotype
(Yu et al., 2005)
involved_in axon ensheathment in central nervous system
inferred from mutant phenotype
(Schwabe et al., 2005, Granderath et al., 1999)
involved_in cortical actin cytoskeleton organization
inferred from mutant phenotype
(Schwabe et al., 2005)
involved_in dorsal/ventral axis specification, ovarian follicular epithelium
inferred from mutant phenotype
(Pathirana et al., 2001)
involved_in embryonic axis specification
inferred from mutant phenotype
(Pathirana et al., 2001)
involved_in establishment of glial blood-brain barrier
inferred from mutant phenotype
(Schwabe et al., 2005)
inferred from mutant phenotype
(Granderath et al., 1999)
involved_in G protein-coupled receptor signaling pathway
inferred from mutant phenotype
(Schwabe et al., 2005)
involved_in glial cell differentiation
inferred from mutant phenotype
(Granderath et al., 1999)
involved_in heart process
inferred from mutant phenotype
(Yi et al., 2008)
involved_in oocyte dorsal/ventral axis specification
inferred from mutant phenotype
(Pathirana et al., 2001)
involved_in ovarian nurse cell to oocyte transport
inferred from mutant phenotype
(Pathirana et al., 2001)
involved_in regulation of asymmetric cell division
inferred from direct assay
(Yu et al., 2005)
involved_in regulation of G protein-coupled receptor signaling pathway
inferred from genetic interaction with FLYBASE:pins; FB:FBgn0040080
(Yu et al., 2005)
involved_in response to heat
inferred from mutant phenotype
(Lin et al., 2011)
involved_in response to oxidative stress
inferred from mutant phenotype
(Lin et al., 2011)
involved_in response to starvation
inferred from mutant phenotype
(Lin et al., 2011)
involved_in septate junction assembly
inferred from mutant phenotype
(Schwabe et al., 2005)
involved_in ventral cord development
inferred from mutant phenotype
(Schwabe et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in regulation of G protein-coupled receptor signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000851567
(GO Reference Genome Project, 2011-)
involved_in signal transduction
inferred from electronic annotation with InterPro:IPR003116
(InterPro Project Members, 2004-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in apical cortex
inferred from direct assay
(Yu et al., 2005)
located_in cytoplasm
inferred from direct assay
(Schwabe et al., 2005)
located_in plasma membrane
inferred from direct assay
(Schwabe et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000851567
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000851567
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
locomotion defects (loco) encodes a regulator of G-protein signalling protein. loco product functions in neuroblast asymmetric division and blood-brain barrier formation together with G protein-coupled receptors and inhibitory G-proteins (encoded by Gαi and Gαo). It is also known that decrease of loco expression extends lifespan with stronger resistance to stressors. [Date last reviewed: 2018-10-04]
Protein Function (UniProtKB)
Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI and GAP activities on G(i) alpha subunit Galphai. Confers GAP activity on G(o)-alpha subunit Galphao and G(i) alpha subunit Galphai. Involved in the dorsal-ventral axis formation of the egg. Acts as a G-protein signaling for glial cell differentiation during embryogenesis; Galphai, Galphao and the G-protein coupled receptor, moody, are required in the surface glia to achieve effective insulation of the nerve cord. May be essential for nurse cell dumping during oogenesis. Required in neuroblast asymmetrical cell division. Plays a role in stress resistance and life span control.
(UniProt, Q9VCX1)
Summary (Interactive Fly)

regulators of G-protein signalling (RGS) protein - a GTPase-activating protein (GAP) acting on alpha subunit of G-proteins - Mutant glial cells fail to properly ensheath longitudinal axon tracts and do not form the normal glial-glial cell contacts, resulting in a disruption of the blood-brain barrier

Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\loco for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VCX1)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.52

Gene model reviewed during 5.40

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.53

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
loco-RB
FBtr0084275
NM_170032
3993
1175
loco-RC
FBtr0084276
NM_170033
3160
829
loco-RD
FBtr0084273
NM_170030
5330
1541
loco-RF
FBtr0304669
NM_001260312
3133
782
loco-RH
FBtr0309249
NM_001260311
3519
846
Additional Transcript Data and Comments
Reported size (kB)

3.918, 2.918 (longest cDNA)

(Granderath et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
loco-PB
FBpp0083668
129.7
1175
9.86
Q9VCX2
NP_732775
AAF56033
loco-PC
FBpp0083669
91.4
829
9.90
Q8IN00
NP_732776
AAN13916
loco-PD
FBpp0083666
167.3
1541
9.38
Q9VCX1
NP_732773
AAF56034
loco-PF
FBpp0293211
86.2
782
9.55
A0A0B4K7N2
NP_001247241
AFH06559
loco-PH
FBpp0301188
93.4
846
9.70
D5A7N8
NP_001247240
AFH06558
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

1175, 829 (aa); 135, 97 (kD predicted)

(Granderath et al., 1999)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts (via GoLoco and RGS domains) with Galphai (via GDP- or GTP-bound forms).

(UniProt, Q9VCX1)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\loco using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.18

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval peripheral nervous system
(Granderath et al., 1999)
lateral ectoderm | restricted
(Granderath et al., 1999)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
amnioserosa
(Fisher et al., 2012)
antennal primordium
(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)
dorsal sensory complex primordium
(Fisher et al., 2012)
labial sensory complex primordium
(Fisher et al., 2012)
maxillary sensory complex primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
tracheal primordium
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
ventral sensory complex anlage
(Fisher et al., 2012)
embryonic stage 12 -- 16
embryonic/larval tracheal section
(Chung et al., 2011)
embryonic stage 12 -- 17
glial cell
(Granderath et al., 1999)
embryonic stage 13 -- 16
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
embryonic leading edge cell
(Fisher et al., 2012)
embryonic/larval tracheal dorsal trunk
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 16
larval tracheal system
(Granderath et al., 1999)
lateral ectoderm | dorsal
(Granderath et al., 1999)
adult stage | female
germarium

Comment: expression specific to loco-RA and/or loco-RD transcripts

(Pathirana et al., 2001)
oogenesis stage S2 -- S7
cyst cell of ovary | surrounding

Comment: expression specific to loco-RB transcript; in prefollicular mesoderm

(Pathirana et al., 2001)
oogenesis stage S8
follicle cell

Comment: expression specific to loco-RB transcript;

(Pathirana et al., 2001)
oogenesis stage S10
follicle cell | subset

Comment: expression specific to loco-RB transcript; follicle cells in the anterior/dorsal part of the egg chamber

(Pathirana et al., 2001)
oogenesis stage S10 -- S14
nurse cell

Comment: expression specific to loco-RA and/or loco-RD transcripts

(Pathirana et al., 2001)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
pupal stage
organism
(McGurk et al., 2008)
adult stage | male
testis
(McGurk et al., 2008)
Additional Descriptive Data

loco "c2" transcripts are observed in scattered cells in the lateral ectoderm that may correspond to PNS progenitor cells.

(Granderath et al., 1999)

loco "c1" transcripts are detected only weakly. They are first detected in stage 12 embryos. By stage 16, they are detected in glial cells, in dorsal leading edge cells in the lateral ectoderm, and in tracheal cells.

(Granderath et al., 1999)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
larval neuroblast
(Kaplow et al., 2008)
CNS surface glial cell
(Kaplow et al., 2008)
Additional Descriptive Data

fzr protein and loco protein are strongly co-localized along the ventral edge of the larval brain near the margin between the brain and ventral ganglion but not in deeper regions of the brain. Both proteins are expressed within glial cells and are also expressed early in neuroblasts in third instar larvae.

(Kaplow et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in apical cortex
inferred from direct assay
(Yu et al., 2005)
located_in cytoplasm
inferred from direct assay
(Schwabe et al., 2005)
located_in plasma membrane
inferred from direct assay
(Schwabe et al., 2005)
Expression Deduced from Reporters
Reporter: Mi{Trojan-GAL4.0}locoMI02446-TG4.0
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult glial cell | subset
(Lee et al., 2018)
Reporter: P{GAL4-loco.1.3}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
larval glial cell | subset
(Edenfeld et al., 2006)
embryonic stage 11 -- 17
glial cell | lateral
(Granderath et al., 2000)
adult stage
glial cell
(Jhaveri et al., 2004)
adult antennal lobe | restricted
(Jhaveri et al., 2004)
glial cell of adult antennal lobe
(Jhaveri et al., 2004)
glial cell

Comment: expression assayed in cultured cells

(Kuppers-Munther et al., 2004, Tschäpe et al., 2002)
Reporter: P{GAL4-loco.9.6}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16
medial-most cell body glial cell

Comment: not expressed until late embryonic stage 16

(Granderath et al., 2000)
subperineurial glial cell

Comment: not expressed until late embryonic stage 16

(Granderath et al., 2000)
Reporter: P{GAL4-loco.US1}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16
medial-most cell body glial cell

Comment: VUM glial cells

(Granderath et al., 2000)
medial intersegmental nerve root glial cell
(Granderath et al., 2000)
Reporter: P{lacZ.ry+}locorC56
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
CNS glial cell | subset
(Menne and Klambt, 1994)
lateral ectoderm | dorsal
(Granderath et al., 1999)
embryonic stage 12
embryonic longitudinal glial cell
(Klaes et al., 1994)
glial cell of larval VUM neuron
(Klaes et al., 1994)
embryonic stage 12 -- 17
glial cell
(Granderath et al., 1999)
embryonic stage 13 -- 17
segmental nerve root glial cell
(Klaes et al., 1994)
exit glial cell
(Klaes et al., 1994)
larval B-subperineurial glial cell
(Klaes et al., 1994)
larval A-subperineurial glial cell
(Klaes et al., 1994)
medial intersegmental nerve root glial cell
(Klaes et al., 1994)
embryonic stage 16
larval lateral VNC glial cell
(Granderath et al., 2000)
third instar larval stage
larval glial cell
(Kaplow et al., 2008)
larval brain | restricted
(Kaplow et al., 2008)
eye disc
(Kaplow et al., 2008)
Reporter: P{lacZ}loco3-109
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
lateral ectoderm | dorsal
(Granderath et al., 1999)
embryonic stage 12 -- 17
glial cell
(Granderath et al., 1999)
embryonic stage 16
embryonic longitudinal glial cell
(Ito et al., 1995)
segmental nerve root glial cell
(Ito et al., 1995)
larval channel glial cell
(Ito et al., 1995)
subperineurial glial cell
(Ito et al., 1995)
intersegmental nerve root glial cell
(Ito et al., 1995)
embryonic/larval cell body glial cell
(Ito et al., 1995)
first instar larval stage
glial cell of larval central nervous system
(Ito et al., 1995)
larval central nervous system | restricted
(Ito et al., 1995)
Reporter: P{LacZ-loco.Rrk}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11 -- 17
larval lateral VNC glial cell
(Granderath et al., 2000)
tracheal branch primordium
(Granderath et al., 2000)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\loco in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 34 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of loco
Transgenic constructs containing regulatory region of loco
Aberrations (Deficiencies and Duplications) ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
lethal - all die during embryonic stage | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
male semi-sterile
Other Phenotypes
Allele
abnormal behavior | recessive
abnormal immune response | adult stage
abnormal locomotor behavior
abnormal mitotic cell cycle
abnormal mitotic cell cycle (with locoP237)
abnormal mitotic cell cycle (with locoP283)
abnormal neuroanatomy
abnormal neuroanatomy (with locoP237)
abnormal neuroanatomy (with locoP283)
paralytic | recessive
some die during embryonic stage | recessive
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
abdominal tergite 5 | female, with Scer\GAL4Tub.PU
abdominal tergite 6 | female
abdominal tergite 6 | female, with Scer\GAL4Tub.PU
anterior ejaculatory duct
axon | embryonic stage
dorsal appendage
egg
egg | ventral
embryonic/first instar larval cuticle
embryonic/larval midgut primordium
embryonic/larval subperineurial glial cell | larval stage, with Scer\GAL4moody.PS
embryonic foregut
embryonic head
glial cell
hemocyte | adult stage
larval glial cell
larval longitudinal connective
lateral cord surface glia & cell cortex & cortical cytoskeleton
lateral cord surface glia & nucleus
lateral cord surface glia & septate junction
male accessory gland
neuroblast
neuroblast (with locoP237)
neuroblast (with locoP283)
perineurium | embryonic stage
perineurium | embryonic stage, with Scer\GAL4repo
perineurium | larval stage, with Scer\GAL4moody.PS
septate junction | larval stage, with Scer\GAL4moody.PS
spindle & mitotic domain 9
subperineurial glial cell
testis
tormogen cell, with Scer\GAL4pnr-MD237
yolk
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (58)
Hsap\RGS12
11 of 14
Yes
Yes
Hsap\RGS14
6 of 14
No
Yes
Hsap\RGS10
4 of 14
No
Yes
Hsap\AXIN1
2 of 14
No
No
Hsap\AXIN2
2 of 14
No
No
Hsap\CYTIP
2 of 14
No
No
1  
Hsap\GRIP1
2 of 14
No
No
Hsap\LNX1
2 of 14
No
No
1  
Hsap\PARD3B
2 of 14
No
No
Hsap\PARD3
2 of 14
No
No
Hsap\PDZD3
2 of 14
No
No
Hsap\RGS1
2 of 14
No
Yes
Hsap\RGS2
2 of 14
No
No
Hsap\RGS3
2 of 14
No
Yes
Hsap\RGS4
2 of 14
No
Yes
Hsap\RGS5
2 of 14
No
Yes
Hsap\RGS6
2 of 14
No
No
Hsap\RGS7
2 of 14
No
No
Hsap\RGS8
2 of 14
No
No
Hsap\RGS9
2 of 14
No
No
Hsap\RGS11
2 of 14
No
No
Hsap\RGS13
2 of 14
No
No
Hsap\RGS16
2 of 14
No
Yes
Hsap\RGS18
2 of 14
No
No
Hsap\RGS19
2 of 14
No
No
Hsap\RGS20
2 of 14
No
No
Hsap\RGS21
2 of 14
No
No
Hsap\TAMALIN
2 of 14
No
No
Hsap\AKAP10
1 of 14
No
No
Hsap\DLG2
1 of 14
No
No
Hsap\DLG3
1 of 14
No
No
Hsap\DLG5
1 of 14
No
No
1  
Hsap\FRMPD2
1 of 14
No
No
Hsap\GOPC
1 of 14
No
No
Hsap\GRID2IP
1 of 14
No
No
Hsap\LDB3
1 of 14
No
No
1  
Hsap\LIN7B
1 of 14
No
No
Hsap\LNX2
1 of 14
No
No
Hsap\MAGIX
1 of 14
No
No
Hsap\MPDZ
1 of 14
No
No
Hsap\NHERF1
1 of 14
No
No
1  
Hsap\NHERF2
1 of 14
No
No
1  
Hsap\PATJ
1 of 14
No
No
Hsap\PDZD2
1 of 14
No
No
Hsap\PDZD7
1 of 14
No
No
Hsap\PDZD11
1 of 14
No
No
1  
Hsap\PDZK1
1 of 14
No
No
Hsap\PTPN4
1 of 14
No
No
Hsap\PTPN13
1 of 14
No
No
Hsap\RGS17
1 of 14
No
No
Hsap\RHPN1
1 of 14
No
No
Hsap\SCRIB
1 of 14
No
No
1  
Hsap\SNX13
1 of 14
No
No
Hsap\SNX25
1 of 14
No
No
Hsap\SYNJ2BP-COX16
1 of 14
No
Yes
Hsap\SYNJ2BP
1 of 14
No
No
Hsap\USH1C
1 of 14
No
No
Hsap\WHRN
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (52)
Rnor\Rgs12
11 of 14
Yes
Yes
Rnor\Rgs14
6 of 14
No
Yes
Rnor\Rgs10
5 of 14
No
Yes
Rnor\Cytip
2 of 14
No
No
Rnor\Mpdz
2 of 14
No
No
Rnor\Patj
2 of 14
No
No
Rnor\Rgs1
2 of 14
No
Yes
Rnor\Rgs2
2 of 14
No
No
Rnor\Rgs3
2 of 14
No
Yes
Rnor\Rgs4
2 of 14
No
Yes
Rnor\Rgs7
2 of 14
No
No
Rnor\Rgs8
2 of 14
No
No
Rnor\Rgs9
2 of 14
No
No
Rnor\Rgs13
2 of 14
No
No
Rnor\Rgs16
2 of 14
No
Yes
Rnor\Rgs17
2 of 14
No
No
Rnor\Rgs18
2 of 14
No
No
Rnor\Rgs19
2 of 14
No
No
Rnor\Tamalin
2 of 14
No
No
Rnor\Axin1
1 of 14
No
No
Rnor\Axin2
1 of 14
No
No
Rnor\Dlg2
1 of 14
No
No
Rnor\Dlg3
1 of 14
No
No
Rnor\Gopc
1 of 14
No
No
Rnor\Grid2ip
1 of 14
No
No
Rnor\Grip1
1 of 14
No
No
Rnor\Grip2
1 of 14
No
No
Rnor\Il16
1 of 14
No
No
Rnor\Lin7b
1 of 14
No
No
Rnor\Lnx1
1 of 14
No
No
Rnor\Lnx2
1 of 14
No
No
Rnor\Magi2
1 of 14
No
No
Rnor\Magix
1 of 14
No
No
Rnor\Pard3b
1 of 14
No
No
Rnor\Pard3
1 of 14
No
No
Rnor\Pdlim3
1 of 14
No
No
Rnor\Pdzd2
1 of 14
No
No
Rnor\Pdzd3
1 of 14
No
No
Rnor\Pdzd7
1 of 14
No
No
Rnor\Pdzd11
1 of 14
No
No
Rnor\Pdzk1
1 of 14
No
No
Rnor\Ptpn4
1 of 14
No
No
Rnor\Rgs5
1 of 14
No
Yes
Rnor\Rgs6
1 of 14
No
No
Rnor\Rgs20
1 of 14
No
No
Rnor\Rgs21
1 of 14
No
No
Rnor\Slc9a3r1
1 of 14
No
No
Rnor\Slc9a3r2
1 of 14
No
No
Rnor\Stxbp4
1 of 14
No
No
Rnor\Synj2bp
1 of 14
No
Yes
Rnor\Ush1c
1 of 14
No
No
Rnor\Whrn
1 of 14
No
No
Mus musculus (laboratory mouse) (52)
Mmus\Rgs12
10 of 14
Yes
Yes
Mmus\Rgs14
6 of 14
No
Yes
Mmus\Rgs10
5 of 14
No
Yes
Mmus\Axin1
2 of 14
No
No
Mmus\Axin2
2 of 14
No
No
Mmus\Cytip
2 of 14
No
No
Mmus\Grip1
2 of 14
No
No
Mmus\Patj
2 of 14
No
No
Mmus\Rgs1
2 of 14
No
Yes
Mmus\Rgs2
2 of 14
No
No
Mmus\Rgs3
2 of 14
No
Yes
Mmus\Rgs4
2 of 14
No
Yes
Mmus\Rgs5
2 of 14
No
Yes
Mmus\Rgs8
2 of 14
No
No
Mmus\Rgs9
2 of 14
No
No
Mmus\Rgs11
2 of 14
No
No
Mmus\Rgs13
2 of 14
No
No
Mmus\Rgs16
2 of 14
No
Yes
Mmus\Rgs17
2 of 14
No
No
Mmus\Rgs18
2 of 14
No
No
Mmus\Rgs19
2 of 14
No
No
Mmus\Rgs20
2 of 14
No
No
Mmus\Rgs21
2 of 14
No
No
Mmus\Tamalin
2 of 14
No
No
Mmus\Dlg2
1 of 14
No
No
Mmus\Dlg3
1 of 14
No
No
Mmus\Dlg5
1 of 14
No
No
Mmus\Gm20498
1 of 14
No
Yes
Mmus\Grid2ip
1 of 14
No
No
Mmus\Grip2
1 of 14
No
No
Mmus\Il16
1 of 14
No
No
Mmus\Ldb3
1 of 14
No
No
Mmus\Lin7b
1 of 14
No
No
Mmus\Lnx1
1 of 14
No
No
Mmus\Lnx2
1 of 14
No
No
Mmus\Magix
1 of 14
No
No
Mmus\Mpdz
1 of 14
No
No
Mmus\Pard3b
1 of 14
No
No
Mmus\Pard3
1 of 14
No
No
Mmus\Pdzd2
1 of 14
No
No
Mmus\Pdzd3
1 of 14
No
No
Mmus\Pdzd11
1 of 14
No
No
Mmus\Pdzk1
1 of 14
No
No
Mmus\Pdzph1
1 of 14
No
No
Mmus\Ptpn4
1 of 14
No
No
Mmus\Rgs6
1 of 14
No
No
Mmus\Rgs7
1 of 14
No
No
Mmus\Slc9a3r1
1 of 14
No
No
Mmus\Slc9a3r2
1 of 14
No
No
Mmus\Synj2bp
1 of 14
No
Yes
Mmus\Ush1c
1 of 14
No
No
Mmus\Whrn
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (30)
Xtro\rgs12
9 of 13
Yes
Yes
Xtro\rgs14
3 of 13
No
Yes
Xtro\adcyap1r1
1 of 13
No
Yes
Xtro\adra2b
1 of 13
No
No
Xtro\ahsg
1 of 13
No
Yes
Xtro\axin1
1 of 13
No
No
Xtro\axin2
1 of 13
No
No
Xtro\cbl
1 of 13
No
No
Xtro\cytip
1 of 13
No
No
Xtro\efhc2
1 of 13
No
No
Xtro\lmod1
1 of 13
No
No
Xtro\lnx2
1 of 13
No
No
Xtro\mpdz
1 of 13
No
No
Xtro\pdlim1
1 of 13
No
No
Xtro\pnck
1 of 13
No
No
Xtro\rgs1
1 of 13
No
No
Xtro\rgs3
1 of 13
No
No
Xtro\rgs8
1 of 13
No
No
Xtro\rgs10
1 of 13
No
Yes
Xtro\rgs13
1 of 13
No
No
Xtro\rgs18
1 of 13
No
No
Xtro\rgs20
1 of 13
No
No
Xtro\rgs22
1 of 13
No
Yes
Xtro\sema6d
1 of 13
No
No
Xtro\slc9a3r1
1 of 13
No
No
Xtro\snx13
1 of 13
No
No
Xtro\snx25
1 of 13
No
No
Xtro\spring1
1 of 13
No
No
Xtro\tamalin
1 of 13
No
No
Xtro\thra
1 of 13
No
Yes
Danio rerio (Zebrafish) (56)
Drer\rgs12a
11 of 14
Yes
Yes
Drer\rgs12b
11 of 14
Yes
Yes
Drer\rgs14a
6 of 14
No
Yes
Drer\rgs14b
6 of 14
No
Yes
Drer\cytip
2 of 14
No
No
Drer\grip1
2 of 14
No
No
Drer\rgs1
2 of 14
No
No
Drer\rgs4
2 of 14
No
No
Drer\rgs5a
2 of 14
No
Yes
Drer\rgs5b
2 of 14
No
No
Drer\rgs7a
2 of 14
No
No
Drer\rgs8
2 of 14
No
No
Drer\rgs9b
2 of 14
No
No
Drer\rgs11
2 of 14
No
No
Drer\rgs13
2 of 14
No
No
Drer\rgs16
2 of 14
No
No
Drer\rgs18
2 of 14
No
No
Drer\si:ch211-152p11.4
2 of 14
No
No
Drer\si:dkey-276j7.2
2 of 14
No
No
Drer\tamalin
2 of 14
No
No
Drer\axin1
1 of 14
No
No
Drer\axin2
1 of 14
No
No
Drer\dlg4
1 of 14
No
No
Drer\dlg5a
1 of 14
No
No
Drer\gopc
1 of 14
No
No
Drer\grid2ipb
1 of 14
No
No
Drer\grip2a
1 of 14
No
No
Drer\lin7b
1 of 14
No
No
Drer\lin7c
1 of 14
No
No
Drer\lnx1
1 of 14
No
No
Drer\lnx2a
1 of 14
No
No
Drer\lnx2b
1 of 14
No
No
Drer\pdzd3a
1 of 14
No
No
Drer\pdzd3b
1 of 14
No
No
Drer\pdzd7a
1 of 14
No
No
Drer\pdzd11
1 of 14
No
No
Drer\pdzk1
1 of 14
No
No
Drer\ptpn4b
1 of 14
No
No
Drer\rgs2
1 of 14
No
No
Drer\rgs3a
1 of 14
No
No
Drer\rgs3b
1 of 14
No
Yes
Drer\rgs6
1 of 14
No
No
Drer\rgs7b
1 of 14
No
No
Drer\rgs9a
1 of 14
No
No
Drer\rgs17
1 of 14
No
No
Drer\rgs19
1 of 14
No
No
Drer\rgs20
1 of 14
No
No
Drer\si:ch211-117l17.5
1 of 14
No
No
Drer\si:ch211-117l17.6
1 of 14
No
No
Drer\si:ch211-196h16.12
1 of 14
No
No
Drer\si:dkey-92j12.5
1 of 14
No
No
Drer\slc9a3r1a
1 of 14
No
No
Drer\snx27a
1 of 14
No
No
Drer\synj2bp
1 of 14
No
Yes
Drer\ush1c
1 of 14
No
No
Drer\whrna
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (31)
Cele\gras-1
2 of 14
Yes
No
Cele\rgs-6
2 of 14
Yes
No
Cele\rgs-7
2 of 14
Yes
No
Cele\rgs-8.1
2 of 14
Yes
No
Cele\rgs-8.2
2 of 14
Yes
No
Cele\rgs-9
2 of 14
Yes
No
Cele\rgs-10
2 of 14
Yes
No
Cele\rgs-11
2 of 14
Yes
Yes
Cele\C46H11.6
1 of 14
No
Yes
Cele\C50F7.3
1 of 14
No
Yes
Cele\C52A11.3
1 of 14
No
No
Cele\eat-16
1 of 14
No
No
Cele\egl-10
1 of 14
No
No
Cele\F16G10.5
1 of 14
No
No
Cele\F20D6.1
1 of 14
No
Yes
Cele\F28E10.4
1 of 14
No
Yes
Cele\F40F9.3
1 of 14
No
Yes
Cele\mics-1
1 of 14
No
No
Cele\mpz-1
1 of 14
No
No
Cele\mpz-4
1 of 14
No
Yes
Cele\rgs-1
1 of 14
No
No
Cele\rgs-2
1 of 14
No
No
Cele\rgs-3
1 of 14
No
No
Cele\rgs-4
1 of 14
No
No
Cele\rgs-5
1 of 14
No
No
Cele\rhgf-1
1 of 14
No
No
Cele\smz-1
1 of 14
No
Yes
Cele\smz-2
1 of 14
No
Yes
Cele\T19B10.5
1 of 14
No
Yes
Cele\txt-1
1 of 14
No
Yes
Cele\ZK849.1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (28)
Agam\AgaP_AGAP002411
10 of 12
Yes
Yes
Agam\AgaP_AGAP000232
2 of 12
No
No
Agam\AgaP_AGAP002123
2 of 12
No
No
Agam\AgaP_AGAP003718
2 of 12
No
No
Agam\AgaP_AGAP006605
2 of 12
No
No
Agam\AgaP_AGAP006629
2 of 12
No
No
Agam\AgaP_AGAP007127
2 of 12
No
No
Agam\AgaP_AGAP000121
1 of 12
No
No
Agam\AgaP_AGAP000209
1 of 12
No
No
Agam\AgaP_AGAP000869
1 of 12
No
No
Agam\AgaP_AGAP002145
1 of 12
No
No
Agam\AgaP_AGAP002322
1 of 12
No
No
Agam\AgaP_AGAP002323
1 of 12
No
No
Agam\AgaP_AGAP003604
1 of 12
No
No
Agam\AgaP_AGAP004701
1 of 12
No
No
Agam\AgaP_AGAP005235
1 of 12
No
No
Agam\AgaP_AGAP007108
1 of 12
No
No
Agam\AgaP_AGAP007865
1 of 12
No
No
Agam\AgaP_AGAP008221
1 of 12
No
No
Agam\AgaP_AGAP008384
1 of 12
No
No
Agam\AgaP_AGAP010413
1 of 12
No
No
Agam\AgaP_AGAP010776
1 of 12
No
No
Agam\AgaP_AGAP010778
1 of 12
No
No
Agam\AgaP_AGAP010808
1 of 12
No
No
Agam\AgaP_AGAP011138
1 of 12
No
No
Agam\AgaP_AGAP011205
1 of 12
No
Yes
Agam\AgaP_AGAP012008
1 of 12
No
No
Agam\AgaP_AGAP012354
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\RGS2
1 of 13
Yes
No
Scer\SST2
1 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\rgs1
2 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:loco. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (32)
Dhit
3 of 13
RSG7
3 of 13
Axn
2 of 13
bbg
2 of 13
CG42450
2 of 13
Patj
2 of 13
ssp6
2 of 13
a
1 of 13
baz
1 of 13
CG5921
1 of 13
CG6688
1 of 13
CG10939
1 of 13
CG15617
1 of 13
CG15803
1 of 13
CG34375
1 of 13
CG42319
1 of 13
CG43707
1 of 13
cno
1 of 13
Dlg5
1 of 13
dysc
1 of 13
Efa6
1 of 13
Fife
1 of 13
Grip
1 of 13
inaD
1 of 13
Mhcl
1 of 13
PsGEF
1 of 13
snz
1 of 13
sprt
1 of 13
Syn1
1 of 13
X11L
1 of 13
Zasp66
1 of 13
Zasp67
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
locoGD1282
ameliorates  Huntington's disease
modeled by Hsap\HTT128Q.1-336.UAS
(Al-Ramahi et al., 2018)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
RGS12; regulator of G protein signaling 12
11 of 14
602512
      RGS14; regulator of G protein signaling 14
      6 of 14
      602513
          RGS10; regulator of G protein signaling 10
          4 of 14
          602856
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              Summary of Genetic Interactions
              Interaction Browsers
              View in FlyBase Interactions Browser   View in MIST tool (external link)
              Please look at the allele data for full details of the genetic interactions
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              loco
              enhanceable
              pins
              (Yu et al., 2005)
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              fzr
              suppressible
              loco
              (Kaplow et al., 2008)
              Pka-C1
              suppressible
              loco
              (Li et al., 2021)
              External Data
              Subunit Structure (UniProtKB)
              Interacts (via GoLoco and RGS domains) with Galphai (via GDP- or GTP-bound forms).
              (UniProt, Q9VCX1 )
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              FlyBase
              External Links
              External Data
              Linkouts
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              SignaLink - A signaling pathway resource with multi-layered regulatory networks.
              Class of Gene
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              3R
              Recombination map
              3-75
              Cytogenetic map
              94B6-94B8
              Sequence location
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              94B6-94B8
              Limits computationally determined from genome sequence between P{lacW}Dph5L4910 and P{lacW}GclmL0580
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              94B-94C
              (Pathirana, 2000.3.15, Granderath, 1999.2.24)
              94B-94C
              (determined by in situ hybridisation)
              (Granderath et al., 1999)
              Experimentally Determined Recombination Data
              Location

              3-75

              (FlyBase, 2016)

              3-77.8

              (Comeron et al., 2012)
              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (16)
              Genomic Clones (21)
              cDNA Clones (59)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 
                  Other Comments

                  Embryos transfected with dsRNA made from templates generated with primers directed against this gene show defects in the formation of the blood-brain barrier. The hatching rate of embryos transfected with loco dsRNA is much lower than controls and locomotor behaviour of larvae that do hatch is often severely impaired.

                  (Schwabe et al., 2005)

                  Identified with:GH08607

                  (Yu et al., 2005)

                  dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                  (Kiger et al., 2003)

                  Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. Shows significant change of expression pattern in circadian mutant background; decreased expression in per01, tim01 and ClkJrk background.

                  (Claridge-Chang et al., 2001)

                  loco is required for dorsal ventral axis formation of the egg and embryo and nurse cell dumping.

                  (Pathirana et al., 2001)

                  loco is required for glial differentiation.

                  (Granderath et al., 1999)

                  loco mutant embryos show a severe glial cell differentiation defect.

                  (Granderath et al., 1999)

                  Identification: Enhancer-trap technique to analyse possible glial specific target genes of pnt has identified loco.

                  (Granderath and Klambt, 1997)

                  Enhancer trap technique to analyse glia-specific target genes of pnt has identified loco.

                  (Granderath and Klämbt, 1997)
                  Relationship to Other Genes
                  Source for database merge of

                  Source for merge of: loco CG17229

                  (FlyBase Genome Annotators, 2002-2003)
                  Additional comments

                  Annotations CG5248 and CG17229 merged as CG5248 in release 3 of the genome annotation.

                  (FlyBase Genome Annotators, 2002-2003)
                  Nomenclature History
                  Source for database identify of
                  Nomenclature comments
                  Etymology
                  Synonyms and Secondary IDs (9)
                  Reported As
                  Symbol Synonym
                  CG17229
                  (Stathopoulos et al., 2002)
                  CG5248
                  (Schertel et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Wittkopp et al., 2008)
                  LOCO
                  (Kim et al., 2015)
                  Loco
                  (Kim et al., 2020, Yaghmaeian Salmani and Thor, 2020, Kopp and Park, 2019, Lin et al., 2014, Kelsom and Lu, 2012, Chung et al., 2011, Guenin et al., 2010, Kopein and Katanaev, 2009, Chia et al., 2008, Lin, 2008, Bakal et al., 2007, Kaplow et al., 2007, Formstecher et al., 2005)
                  dLoco
                  (Zheng et al., 1999)
                  loco
                  (Corthals et al., 2023, Floc'hlay et al., 2023, Lee et al., 2023, Guzman et al., 2021, Engel et al., 2019, Highfill et al., 2019, Matsuno et al., 2019, Mazaud et al., 2019, Al-Ramahi et al., 2018, Lee et al., 2018, Lin et al., 2018, Fochler et al., 2017, Rohde et al., 2017, Schwabe et al., 2017, Altenhein et al., 2016, Gene Disruption Project members, 2016-, Mahajan et al., 2016, Dembeck et al., 2015, Grice et al., 2015, Kopp et al., 2015, Ashwal-Fluss et al., 2014, DeSalvo et al., 2014, Kerr et al., 2014, Lin et al., 2014, Schertel et al., 2013, Sen et al., 2013, Kaun et al., 2012, Friedman et al., 2011, Lin et al., 2011, Lin et al., 2011, Dworkin et al., 2009, Levis, 2009.3.18, Jin et al., 2008, Kaplow et al., 2008, McGurk et al., 2008, Wittkopp et al., 2008, Xi et al., 2008, Yi et al., 2008, Bakal et al., 2007, Kaplow et al., 2007, Thomas and van Meyel, 2007, Cho et al., 2005, Daneman and Barres, 2005, Reeves and Posakony, 2005, Schwabe et al., 2005)
                  Name Synonyms
                  Locomotion defect
                  (Lin, 2008)
                  Locomotion defects
                  (Chia et al., 2008)
                  locomotion defects
                  (Shafer, 2025, Granderath et al., 1999)
                  Secondary FlyBase IDs
                  • FBgn0038997
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 84 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  FlyMine - An integrated database for Drosophila genomics
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                  References (132)