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FB2026_02
,
released June 18, 2026
Several GWAS studies have implicated the human gene RGS14 in kidney dysfunction. RGS14 encodes a member of the regulator of G protein signaling (RGS) gene family; RGS proteins downregulate G protein signaling via binding to the G alpha subunits. There are multiple genes in this family in both human and Drosophila; RGS14 is most closely related to the Drosophila gene loco. Dmel\loco is also closely related to RGS12 and RGS10. Classical loss-of-function mutations, RNAi targeting constructs, and alleles caused by insertional mutagenesis have been generated for Dmel\loco.
The human RGS14 gene has not been introduced into flies.
Animals heterozygous for an amorphic mutation of Dmel\loco exhibit increased resistance to salt stress (using NaCl in the food). Animals homozygous for loss-of-function mutations have reduced survival to the adult stage; surviving adults exhibit severe locomotor defects and reduced lifespan. Embryos lacking both maternal and zygotic components exhibit defects in mitotic spindle orientation. Physical and genetic interactions have been described for Dmel\loco; see below and in the loco gene report.
[updated Feb. 2018 by FlyBase; FBrf0222196]
Reduced estimated glomerular filtration rate (eGFR), a key indicator of renal function; based on a trans-ethnic meta-analysis of nine GWASs comprising 71,638 individuals of diverse ancestries (FBrf0233321).
RGS14 is associated with kidney dysfunction in multiple GWAS studies (see GWAS Catalog, below in 'External links').
RGS14 encodes a member of the regulator of G-protein signaling family; members of this family inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. [Gene Cards, RGS14; 2018.02.22]
Many to many: multiple genes in both species. Most closely related to Dmel\loco (short isoform).
Moderate- to high-scoring ortholog of RGS12 and RGS14; lower-scoring ortholog of multiple other human genes (many to many). Dmel\loco shares 27-28% identity and 41% similarity with RGS12 and RGS14. RGS12 contains amino-terminal domains found only in the longest Dmel\loco isoform; RGS14 is a shorter protein similar to shorter protein isoforms of Dmel\loco.