FlyBase Allele Report: Dmel\loco[Δ293]

General Information

Symbol

Dmel\loco^Δ293

Species

D. melanogaster

Name

FlyBase ID

FBal0096757

Feature type

allele

Associated gene

Dmel\loco

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Granderath et al., 1999)

Mutagen

P-element activity

(Granderath et al., 1999)

Progenitor genotype

loco^rC56

(Granderath et al., 1999)

Cytology

Description

Deletion of approximately 2kb extending mainly in the 3' direction removing the site of insertion in loco^rC56, deleting exon I-1 and the following intron. A small inversion is also associated with this mutation.

(Granderath et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Granderath et al., 1999)

some die during embryonic stage | recessive

(Granderath et al., 1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

When loco^Δ13 or loco^Δ293 are trans with loco^M1 at 25^oC escapers are produced. Escapers show a paralytic phenotype, and drop into the food and die of not rescued. Rescued adults show a severe impairment of spontaneous locomotor activity and show a shaking phenotype. Response to mechanical stimulation is weak (for loco^Δ293) and non-existent (for loco^Δ13). All adult escapers die after a maximum of 2 days.

(Granderath et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions