FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Gene: Dmel\CG10939
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General Information
Symbol
Dmel\CG10939
Species
D. melanogaster
Name
Annotation Symbol
CG10939
Feature Type
protein_coding_gene
FlyBase ID
FBgn0010620
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Summary
CG10939 encodes a protein that functions as a scaffold linking the plasma membrane and cytoskeletal linker proteins encoded by Mer and Moe. Via interaction with the products of Slik and flw, it regulates the activity of the products of Mer and Moe in epithelial cell adhesion. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Sip1, l(2)06373, SRY interacting protein 1

Key Links
Genomic Location
Cytogenetic map
54B6-54B7
Sequence location
Recombination map
2-82
RefSeq locus
NT_033778 REGION:17394593..17405171
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables molecular adaptor activity
inferred from physical interaction with FLYBASE:Moe; FB:FBgn0011661,FLYBASE:Slik; FB:FBgn0035001
(Hughes et al., 2010)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables protein-membrane adaptor activity
inferred from biological aspect of ancestor with PANTHER:PTN001021694
(GO Reference Genome Project, 2011-)
Biological Process (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in actin cytoskeleton organization
inferred from mutant phenotype
(Hughes et al., 2010)
involved_in epithelial structure maintenance
inferred from genetic interaction with FLYBASE:Moe; FB:FBgn0011661
(Hughes et al., 2010)
involved_in negative regulation of cell population proliferation
inferred from genetic interaction with FLYBASE:Mer; FB:FBgn0086384
(Abeysundara et al., 2014)
involved_in positive regulation of cell-cell adhesion
inferred from genetic interaction with FLYBASE:Mer; FB:FBgn0086384
(Abeysundara et al., 2014)
involved_in regulation of renal system process
inferred from mutant phenotype
(Ghimire et al., 2019)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in protein localization to plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN001021694
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
is_active_in cytoplasmic side of apical plasma membrane
inferred from direct assay
(Ghimire et al., 2019, Hughes et al., 2010)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in apical plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN001021694
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
CG10939 encodes a protein that functions as a scaffold linking the plasma membrane and cytoskeletal linker proteins encoded by Mer and Moe. Via interaction with the products of Slik and flw, it regulates the activity of the products of Mer and Moe in epithelial cell adhesion. [Date last reviewed: 2019-09-26]
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\CG10939 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q7K5M6)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG10939-RA
FBtr0086909
NM_079973
1717
296
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
CG10939-PA
FBpp0086065
30.7
296
9.94
Q7K5M6
NP_524712
AAF57879
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG10939 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.63

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
anterior endoderm anlage
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
anterior endoderm
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
larval foregut atrium | precursor

Comment: reported as atrium primordium

(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
larval foregut atrium
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic esophagus
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic hypopharynx
(Fisher et al., 2012)
embryonic large intestine
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
is_active_in cytoplasmic side of apical plasma membrane
inferred from direct assay
(Ghimire et al., 2019, Hughes et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG10939 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG10939
Transgenic constructs containing regulatory region of CG10939
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2R)Exel7147
(Ryder, 2004.4.26)
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (37)
Hsap\NHERF1
8 of 14
Yes
Yes
1  
Hsap\NHERF2
8 of 14
Yes
Yes
1  
Hsap\PDZD3
4 of 14
No
Yes
Hsap\PDZK1
4 of 14
No
Yes
Hsap\CYTIP
2 of 14
No
No
1  
Hsap\FRMPD2
2 of 14
No
Yes
Hsap\MPDZ
2 of 14
No
No
Hsap\PARD3
2 of 14
No
No
Hsap\PATJ
2 of 14
No
No
Hsap\PDZK1P1
2 of 14
No
Yes
Hsap\TAMALIN
2 of 14
No
No
Hsap\USH1C
2 of 14
No
No
Hsap\WHRN
2 of 14
No
No
Hsap\ARHGAP23
1 of 14
No
No
Hsap\DLG3
1 of 14
No
No
Hsap\DLG5
1 of 14
No
No
1  
Hsap\GOPC
1 of 14
No
No
Hsap\GRID2IP
1 of 14
No
No
Hsap\GRIP1
1 of 14
No
No
Hsap\LIN7A
1 of 14
No
No
Hsap\LIN7B
1 of 14
No
No
Hsap\LNX1
1 of 14
No
No
1  
Hsap\LNX2
1 of 14
No
No
Hsap\MAGI1
1 of 14
No
No
Hsap\MAGI2
1 of 14
No
No
Hsap\PARD3B
1 of 14
No
No
Hsap\PDZD2
1 of 14
No
No
Hsap\PDZD7
1 of 14
No
No
Hsap\PDZD11
1 of 14
No
No
1  
Hsap\PDZRN3
1 of 14
No
No
Hsap\PTPN13
1 of 14
No
No
Hsap\RGS12
1 of 14
No
No
Hsap\SCRIB
1 of 14
No
No
1  
Hsap\SHANK1
1 of 14
No
No
Hsap\SNX27
1 of 14
No
No
Hsap\SYNJ2BP-COX16
1 of 14
No
Yes
Hsap\SYNJ2BP
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (30)
Rnor\Slc9a3r2
8 of 14
Yes
Yes
Rnor\Slc9a3r1
7 of 14
No
Yes
Rnor\Pdzd3
4 of 14
No
Yes
Rnor\Pdzk1
4 of 14
No
Yes
Rnor\Cytip
2 of 14
No
No
Rnor\Mpdz
2 of 14
No
No
Rnor\Tamalin
2 of 14
No
No
Rnor\Arhgef12
1 of 14
No
No
Rnor\Gopc
1 of 14
No
No
Rnor\Grip2
1 of 14
No
No
Rnor\Il16
1 of 14
No
No
Rnor\Lin7a
1 of 14
No
No
Rnor\Lin7b
1 of 14
No
No
Rnor\Lnx1
1 of 14
No
No
Rnor\Lnx2
1 of 14
No
No
Rnor\Magi2
1 of 14
No
No
Rnor\Mast2
1 of 14
No
No
Rnor\Mast3
1 of 14
No
No
Rnor\Pard3b
1 of 14
No
No
Rnor\Pard3
1 of 14
No
No
Rnor\Patj
1 of 14
No
No
Rnor\Pdzd2
1 of 14
No
No
Rnor\Pdzd7
1 of 14
No
No
Rnor\Pdzd11
1 of 14
No
No
Rnor\Shank1
1 of 14
No
No
Rnor\Snx27
1 of 14
No
No
Rnor\Stxbp4
1 of 14
No
No
Rnor\Synj2bp
1 of 14
No
Yes
Rnor\Ush1c
1 of 14
No
No
Rnor\Whrn
1 of 14
No
No
Mus musculus (laboratory mouse) (31)
Mmus\Slc9a3r2
9 of 14
Yes
Yes
Mmus\Slc9a3r1
8 of 14
No
Yes
Mmus\Pdzd3
4 of 14
No
Yes
Mmus\Pdzk1
3 of 14
No
Yes
Mmus\Cytip
2 of 14
No
No
Mmus\Mpdz
2 of 14
No
No
Mmus\Pdzph1
2 of 14
No
No
Mmus\Tamalin
2 of 14
No
No
Mmus\Dlg5
1 of 14
No
No
Mmus\Gm20498
1 of 14
No
Yes
Mmus\Grid2ip
1 of 14
No
No
Mmus\Grip1
1 of 14
No
No
Mmus\Grip2
1 of 14
No
No
Mmus\Il16
1 of 14
No
No
Mmus\Lin7a
1 of 14
No
No
Mmus\Lin7b
1 of 14
No
No
Mmus\Lnx1
1 of 14
No
No
Mmus\Lnx2
1 of 14
No
No
Mmus\Magi1
1 of 14
No
No
Mmus\Magi2
1 of 14
No
No
Mmus\Mast3
1 of 14
No
No
Mmus\Pard3b
1 of 14
No
No
Mmus\Pard3
1 of 14
No
No
Mmus\Patj
1 of 14
No
No
Mmus\Pdzd2
1 of 14
No
No
Mmus\Pdzd11
1 of 14
No
No
Mmus\Shank1
1 of 14
No
No
Mmus\Snx27
1 of 14
No
No
Mmus\Synj2bp
1 of 14
No
Yes
Mmus\Ush1c
1 of 14
No
No
Mmus\Whrn
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (20)
Xtro\slc9a3r1
6 of 13
Yes
Yes
Xtro\slc9a3r2
6 of 13
Yes
Yes
Xtro\pdzk1
4 of 13
No
Yes
Xtro\pdzd3
3 of 13
No
Yes
Xtro\spring1
2 of 13
No
No
Xtro\adcyap1r1
1 of 13
No
Yes
Xtro\adra2b
1 of 13
No
No
Xtro\cbl
1 of 13
No
No
Xtro\cytip
1 of 13
No
No
Xtro\gga1
1 of 13
No
No
Xtro\lin7b
1 of 13
No
No
Xtro\magi3
1 of 13
No
No
Xtro\mpdz
1 of 13
No
No
Xtro\rgs12
1 of 13
No
No
Xtro\rgs18
1 of 13
No
No
Xtro\shank1
1 of 13
No
No
Xtro\slc15a4
1 of 13
No
No
Xtro\tamalin
1 of 13
No
No
Xtro\thra
1 of 13
No
Yes
Xtro\whrn
1 of 13
No
No
Danio rerio (Zebrafish) (33)
Drer\slc9a3r1a
8 of 14
Yes
Yes
Drer\slc9a3r1b
6 of 14
No
Yes
Drer\pdzd3a
4 of 14
No
Yes
Drer\pdzk1
4 of 14
No
Yes
Drer\LOC100008366
3 of 14
No
Yes
Drer\pdzd3b
3 of 14
No
Yes
Drer\cytip
2 of 14
No
No
Drer\gopc
2 of 14
No
Yes
Drer\LOC100535100
2 of 14
No
Yes
Drer\si:dkey-276j7.2
2 of 14
No
No
Drer\tamalin
2 of 14
No
No
Drer\arhgap21a
1 of 14
No
No
Drer\dlg5a
1 of 14
No
No
Drer\grid2ipb
1 of 14
No
No
Drer\grip1
1 of 14
No
No
Drer\grip2a
1 of 14
No
No
Drer\grip2b
1 of 14
No
No
Drer\lin7a
1 of 14
No
No
Drer\lin7b
1 of 14
No
No
Drer\lnx1
1 of 14
No
No
Drer\lnx2a
1 of 14
No
No
Drer\lnx2b
1 of 14
No
No
Drer\magi2a
1 of 14
No
No
Drer\mast1b
1 of 14
No
No
Drer\mast3b
1 of 14
No
No
Drer\myo18aa
1 of 14
No
No
Drer\pdzd11
1 of 14
No
No
Drer\shank1
1 of 14
No
No
Drer\snx27b
1 of 14
No
No
Drer\synj2bp
1 of 14
No
Yes
Drer\ush1c
1 of 14
No
No
Drer\whrna
1 of 14
No
No
Drer\whrnb
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (18)
Cele\nrfl-1
6 of 14
Yes
Yes
Cele\gras-1
2 of 14
No
No
Cele\C46H11.6
1 of 14
No
Yes
Cele\C50F7.3
1 of 14
No
Yes
Cele\C52A11.3
1 of 14
No
No
Cele\dlg-1
1 of 14
No
No
Cele\F16G10.5
1 of 14
No
No
Cele\F20D6.1
1 of 14
No
Yes
Cele\F28E10.4
1 of 14
No
Yes
Cele\F40F9.3
1 of 14
No
Yes
Cele\magi-1
1 of 14
No
No
Cele\mics-1
1 of 14
No
No
Cele\mpz-4
1 of 14
No
Yes
Cele\smz-1
1 of 14
No
Yes
Cele\smz-2
1 of 14
No
Yes
Cele\T19B10.5
1 of 14
No
Yes
Cele\txt-1
1 of 14
No
Yes
Cele\ZK849.1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (24)
Agam\AgaP_AGAP012008
9 of 12
Yes
Yes
Agam\AgaP_AGAP002145
2 of 12
No
No
Agam\AgaP_AGAP002322
2 of 12
No
No
Agam\AgaP_AGAP006605
2 of 12
No
No
Agam\AgaP_AGAP000121
1 of 12
No
No
Agam\AgaP_AGAP000209
1 of 12
No
No
Agam\AgaP_AGAP000869
1 of 12
No
No
Agam\AgaP_AGAP001110
1 of 12
No
No
Agam\AgaP_AGAP002323
1 of 12
No
No
Agam\AgaP_AGAP003604
1 of 12
No
No
Agam\AgaP_AGAP004701
1 of 12
No
No
Agam\AgaP_AGAP005235
1 of 12
No
No
Agam\AgaP_AGAP007108
1 of 12
No
No
Agam\AgaP_AGAP007865
1 of 12
No
No
Agam\AgaP_AGAP008221
1 of 12
No
No
Agam\AgaP_AGAP008384
1 of 12
No
No
Agam\AgaP_AGAP010413
1 of 12
No
No
Agam\AgaP_AGAP010776
1 of 12
No
No
Agam\AgaP_AGAP010778
1 of 12
No
No
Agam\AgaP_AGAP010808
1 of 12
No
No
Agam\AgaP_AGAP011030
1 of 12
No
No
Agam\AgaP_AGAP011138
1 of 12
No
No
Agam\AgaP_AGAP011205
1 of 12
No
Yes
Agam\AgaP_AGAP012354
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:CG10939. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (27)
baz
2 of 13
CG5921
2 of 13
dysc
2 of 13
ssp6
2 of 13
a
1 of 13
bbg
1 of 13
CG6688
1 of 13
CG15617
1 of 13
CG15803
1 of 13
CG34375
1 of 13
CG42319
1 of 13
CG43707
1 of 13
Dlg5
1 of 13
Fife
1 of 13
Grip
1 of 13
inaD
1 of 13
loco
1 of 13
Magi
1 of 13
Mhcl
1 of 13
Patj
1 of 13
PsGEF
1 of 13
Snx27
1 of 13
sprt
1 of 13
Syn1
1 of 13
X11L
1 of 13
Zasp66
1 of 13
Zasp67
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
NHERF1; NHERF family PDZ scaffold protein 1
8 of 14
604990
 
NHERF2; NHERF family PDZ scaffold protein 2
8 of 14
SOLUTE CARRIER FAMILY 9, MEMBER 3, REGULATOR 2; SLC9A3R2
       
      NHERF4; NHERF family PDZ scaffold protein 4
      4 of 14
      607146
          PDZK1; PDZ domain containing 1
          4 of 14
          603831
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              Summary of Genetic Interactions
              Interaction Browsers
              View in FlyBase Interactions Browser   View in MIST tool (external link)
              Please look at the allele data for full details of the genetic interactions
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              CG10939
              enhanceable
              Moe
              (Hughes et al., 2010)
              CG10939
              suppressible
              Rho1
              (Hughes et al., 2010)
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              External Data
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              FlyBase
              External Links
              External Data
              Linkouts
              SignaLink - A signaling pathway resource with multi-layered regulatory networks.
              Class of Gene
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              2R
              Recombination map
              2-82
              Cytogenetic map
              54B6-54B7
              Sequence location
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              54B6-54B7
              Limits computationally determined from genome sequence between P{EP}EP1061&P{EP}cnkEP576 and P{EP}l(2)k01209EP2177&P{lacW}k11012a
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              54B4-54B5
              (determined by in situ hybridisation)
              (Spradling et al., 1999)
              54B4-54B5
              (BDGP Project Members, 1994-1999)
              Experimentally Determined Recombination Data
              Location

              2-82

              (FlyBase, 2016)

              2-85.9

              (Comeron et al., 2012)
              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (10)
              Genomic Clones (26)
              cDNA Clones (52)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                Antibody Information
                Laboratory Generated Antibodies
                 

                polyclonal

                (Hughes et al., 2010)
                Commercially Available Antibodies
                 
                Cell Line Information
                Publicly Available Cell Lines
                 
                  Other Stable Cell Lines
                   
                    Other Comments

                    ChEST reveals this is a target of Mef2.

                    (Junion et al., 2005)
                    Relationship to Other Genes
                    Source for database merge of

                    Source for merge of: Sip1 CG10939

                    (Misra, 2000.8.9)
                    Additional comments

                    "Sip1" may correspond to "Scim27". Sequence analysis off ends of P{SUPor-P} in Scim insertion mutant places "Scim27" near/in "Sip1".

                    (Dobie and Karpen, 2001.4.18)
                    Nomenclature History
                    Source for database identify of

                    Source for identity of: CG10939 Sip1

                    (FlyBase, 2009-)
                    Nomenclature comments

                    The gene symbol "Sip1" ("SRY interacting protein 1") has been reverted to "CG10939" as the Sip1 nomenclature is based on orthology to an out-dated human gene symbol which has no meaning in D. melanogaster, and in order to reduce confusion with the "sip1" ("septin interacting protein 1") gene symbol from which it differed only by case.

                    (FlyBase, 2009-)
                    Etymology
                    Synonyms and Secondary IDs (5)
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    Study result (0)
                    Result
                    Result Type
                    Title
                    External Crossreferences and Linkouts ( 40 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                    Other crossreferences
                    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                    FlyMine - An integrated database for Drosophila genomics
                    InterPro - A database of protein families, domains and functional sites
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    MARRVEL_MODEL - MARRVEL (model organism gene)
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                    DroID - A comprehensive database of gene and protein interactions.
                    DRSC - Results frm RNAi screens
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                    Flygut - An atlas of the Drosophila adult midgut
                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                    References (62)