FlyBase Gene Report: Dmel\dysc

General Information

Symbol

Dmel\dysc

Species

D. melanogaster

Name

dyschronic

Annotation Symbol

CG43749

Feature Type

protein_coding_gene

FlyBase ID

FBgn0264006

Gene Model Status

Current

Stock Availability

18 publicly available

Gene Summary

dyschronic (dysc) encodes a protein that regulates the localization of the calcium-activated potassium channel encoded by slo. The product of dysc impacts circadian locomotor patterns, synaptic morphology, active zone structure, and both spontaneous and evoked neurotransmitter release. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Also Known As

Dm_3L:69335

Key Links

Genomic Location

Cytogenetic map

70C5-70C5

Sequence location

3L:13,867,414..13,903,236 [-]

Recombination map

3-41

RefSeq locus

NT_037436 REGION:13867414..13903236

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (6 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in locomotor rhythm

inferred from mutant phenotype

(Jepson et al., 2012)

involved_in muscle cell cellular homeostasis

inferred from mutant phenotype

(Kucherenko et al., 2011)

inferred from genetic interaction with FLYBASE:Dg; FB:FBgn0034072

(Kucherenko et al., 2011)

inferred from genetic interaction with FLYBASE:Dys; FB:FBgn0260003

(Kucherenko et al., 2011)

involved_in negative regulation of neuromuscular synaptic transmission

inferred from mutant phenotype

(Jepson et al., 2014)

involved_in photoreceptor cell axon guidance

inferred from mutant phenotype

(Marrone et al., 2011)

involved_in regulation of synaptic assembly at neuromuscular junction

inferred from mutant phenotype

(Jepson et al., 2014)

involved_in rhabdomere development

inferred from mutant phenotype

(Marrone et al., 2011)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in synapse

inferred from direct assay

(Jepson et al., 2014)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

is_active_in cilium

inferred from biological aspect of ancestor with PANTHER:PTN000563297

(GO Reference Genome Project, 2011-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001136696

(GO Reference Genome Project, 2011-)

part_of stereocilia ankle link complex

inferred from biological aspect of ancestor with PANTHER:PTN000563297

(GO Reference Genome Project, 2011-)

is_active_in stereocilium tip

inferred from biological aspect of ancestor with PANTHER:PTN000563297

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\dysc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry M9PF56)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.52

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.55

Gene model reviewed during 5.56

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Stop-codon suppression (UAA) postulated; FBrf0216884.

Gene model reviewed during 5.44

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

dysc-RC

FBtr0330414

NM_140411

9853

990

dysc-RE

FBtr0330417

NM_001144475

9481

866

dysc-RF

FBtr0330416

NM_001144474

3938

689

dysc-RG

FBtr0330418

NM_001274881

9853

1254

dysc-RH

FBtr0330419

NM_001274882

9928

1015

dysc-RI

FBtr0330420

NM_001274883

9841

986

dysc-RJ

FBtr0333021

NM_001274884

9829

982

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

dysc-PC

FBpp0303440

106.9

990

8.69

FBpp0303443

93.4

866

8.13

FBpp0303442

74.0

689

8.89

FBpp0303444

138.1

1254

8.88

FBpp0303445

109.7

1015

9.10

FBpp0303446

106.4

986

9.01

FBpp0305235

105.9

982

8.99

M9PI53

NP_001261813

AGB94506

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dysc using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

dysc_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.75

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain | restricted

• neuron projection

(Jepson et al., 2012)

adult mushroom body

• neuron projection

(Jepson et al., 2012)

ellipsoid body

• neuron projection

(Jepson et al., 2012)

adult antennal lobe

• neuron projection

(Jepson et al., 2012)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

(Jepson et al., 2012)

Additional Descriptive Data

dysc protein is detected in the neuronal tracts in the adult brain, including the mushroom body lobes, peduncle and calyx, and the ellipsoid body. There is strong colocalisation with slo. The protein levels and expression are not affected by circadian cycling.

(Jepson et al., 2012)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in synapse

inferred from direct assay

(Jepson et al., 2014)

Expression Deduced from Reporters

Reporter: P{dysc-GAL4.J}

Stage

Tissue/Position (including subcellular localization)

Reference

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\dysc in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\dysc

View exonic expression by tissue for Dmel\dysc

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264006

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39533/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264006

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264006

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8760

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 19 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of dysc

Transgenic constructs containing regulatory region of dysc

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3L)BSC614

(Jepson et al., 2012)

Gene partially disrupted in

Df(3L)CRIMIC-CR70014

(Gene Disruption Project members, 2018-)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

dysc^MI02729

lethal, with Scer\GAL4^pnr-MD237

dysc^GD14878

lethal | pupal stage, with Scer\GAL4^pnr-MD237

dysc^GD14878

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Sterility

Allele

fertile

dysc^c03838

Other Phenotypes

Allele

abnormal locomotor rhythm (with Df(3L)BSC614)

abnormal locomotor rhythm (with dysc^c03838)

abnormal locomotor rhythm (with dysc^c05107)

abnormal locomotor rhythm (with dysc^s168)

abnormal locomotor rhythm | recessive

abnormal neuroanatomy | recessive | third instar larval stage

abnormal neuroanatomy | third instar larval stage

abnormal neuroanatomy | third instar larval stage (with dysc^c03838)

dysc^s168

abnormal neuroanatomy | third instar larval stage (with dysc^s168)

dysc^c03838

abnormal neurophysiology | adult stage

dysc^s168

abnormal neurophysiology | third instar larval stage

dysc^c03838

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

dysc^GD13362

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

dysc^GD13362

Phenotype manifest in

Allele

axon | third instar larval stage

dysc^c05107

indirect flight muscle cell, with Scer\GAL4^Tub.PU

dysc^RNAi.UAS.cUa

indirect flight muscle cell (with dysc^c05107)

dysc^c07121

indirect flight muscle cell (with dysc^c07121)

dysc^c05107

lamina plexus | third instar larval stage

dysc^c05107

NMJ bouton

NMJ bouton (with dysc^c03838)

dysc^s168

NMJ bouton (with dysc^s168)

dysc^c03838

rhabdomere | adult stage, with Scer\GAL4^GMR.PU

dysc^GD14018

type Ib terminal bouton

type Ib terminal bouton (with dysc^c03838)

dysc^s168

type Ib terminal bouton (with dysc^s168)

dysc^c03838

type Is terminal bouton

type Is terminal bouton (with dysc^c03838)

dysc^s168

type Is terminal bouton (with dysc^s168)

dysc^c03838

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (59)

Hsap\WHRN

11 of 14

Yes

Hsap\PDZD7

4 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Hsap\PDZK1

2 of 14

Hsap\SYNJ2BP

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\TAX1BP3

1 of 14

Hsap\TJP1

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (46)

Rnor\Whrn

11 of 14

Yes

Rnor\Pdzd7

4 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Tax1bp3

1 of 14

Mus musculus (laboratory mouse) (47)

Mmus\Whrn

10 of 14

Yes

Mmus\Pdzd7

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Tax1bp3

1 of 14

Xenopus tropicalis (Western clawed frog) (28)

Xtro\spring1

8 of 13

Yes

Xtro\whrn

8 of 13

Yes

Xtro\pdzd7

2 of 13

Yes

Xtro\adcyap1r1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\XB5786944

1 of 13

Danio rerio (Zebrafish) (74)

Drer\whrna

11 of 14

Yes

Drer\whrnb

10 of 14

Yes

Drer\pdzd7a

4 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ptpn13

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkey-33c12.10

1 of 14

Drer\si:dkey-33c12.11

1 of 14

Drer\si:dkey-33c12.12

1 of 14

Drer\si:dkey-33c12.13

1 of 14

Drer\si:dkey-84o3.2

1 of 14

Drer\si:dkey-84o3.7

1 of 14

Drer\si:dkey-92j12.5

1 of 14

Drer\si:dkey-112g5.13

1 of 14

Drer\si:dkey-112g5.16

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\tax1bp3

1 of 14

Drer\zgc:174193

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (24)

Cele\gras-1

2 of 14

Yes

Cele\mics-1

2 of 14

Yes

Cele\C46H11.6

1 of 14

Yes

Cele\C50F7.3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\F28E10.4

1 of 14

Yes

Cele\F40F9.3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\nrfl-1

1 of 14

Cele\smz-1

1 of 14

Yes

Cele\smz-2

1 of 14

Yes

Cele\stn-1

1 of 14

Cele\stn-2

1 of 14

Cele\T19B10.5

1 of 14

Yes

Cele\txbp-3

1 of 14

Cele\txt-1

1 of 14

Yes

Cele\ZK849.1

1 of 14

Anopheles gambiae (African malaria mosquito) (35)

Agam\AgaP_AGAP010778

6 of 12

Yes

Agam\AgaP_AGAP010776

3 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP010413

1 of 12

Agam\AgaP_AGAP010779

1 of 12

Yes

Agam\AgaP_AGAP010808

1 of 12

Agam\AgaP_AGAP011138

1 of 12

Agam\AgaP_AGAP011205

1 of 12

Yes

Arabidopsis thaliana (thale-cress) (1)

Atha\DEG14

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (1)

Ecol\degQ

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:dysc. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (35)

CG5921

4 of 13

baz

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

bbg

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

pyd

1 of 13

Rhp

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 5 )

Human Ortholog

Disease

Evidence

References

WHRN; whirlin

model of Usher syndrome type 2D

IEA

(FlyBase, 2019-)

model of autosomal recessive nonsyndromic deafness 31

IEA

(FlyBase, 2019-)

PDZD7; PDZ domain containing 7

model of Usher syndrome type 2C

IEA

(FlyBase, 2019-)

model of autosomal recessive nonsyndromic deafness 57

IEA

(FlyBase, 2019-)

model of Usher syndrome type 2A

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

dysc^s168

ameliorates paroxysmal nonkinesigenic dyskinesia 3

modeled by slo^E366G

(Lowe et al., 2024, Kratschmer et al., 2021)

dysc^GD14018

exacerbates muscular dystrophy

modeled by Dg^O86

(Marrone et al., 2011)

dysc^c03838

exacerbates muscular dystrophy

modeled by Dg³²³

(Kucherenko et al., 2011)

modeled by Dg^O86

(Kucherenko et al., 2011)

modeled by Dg^RNAi.UAS

(Kucherenko et al., 2011)

modeled by Dys^RNAi.NH2.UAS

(Kucherenko et al., 2011)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

WHRN; whirlin

11 of 14

607928

PDZD7; PDZ domain containing 7

4 of 14

612971

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

dysc - slo

anti tag coimmunoprecipitation, western blot

(Jepson et al., 2012)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

dysc

suppressible

slo

(Jepson et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

dysc

(Kucherenko et al., 2011)

Dys

enhanceable

dysc

(Kucherenko et al., 2011)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0264006

MIST (protein-protein) - An integrated Molecular Interaction Database

39533

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

A8JNS6

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-41

Cytogenetic map

70C5-70C5

Sequence location

3L:13,867,414..13,903,236 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

70C5-70C5

Limits computationally determined from genome sequence between P{lacW}l(3)L5212^L5212&P{PZ}l(3)05871⁰⁵⁸⁷¹ and P{EP}EP3561^EP3561

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-41

(FlyBase, 2016)

3-35.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (18)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

71940

w¹¹¹⁸; P{VT030413-GAL4.DBD}attP2

11313

w¹¹¹⁸; PBac{PB}dysc^c03838

83121

y¹ v¹; M{WKO.P5-B2}ZH-86Fb

52114

y¹ w^*; Mi{MIC}dysc^MI05455

59797

y¹ w^*; Mi{PT-GFSTF.0}dysc^{MI02729-GFSTF.0}

Korea

15940

P{VT030413-lexA}JK22C

14205

P{VT030413-lexA::GADfl}attP40

NIG-Fly

32131R-1

P{NIG.32131R}1

HMJ21808

y¹ v¹; P{TRiP.HMJ21808}attP40/CyO

VDRC

v109928

P{KK112280}VIE-260B

v110019

P{KK112696}VIE-260B

v202868

P{VT030413-GAL4}attP2

More stocks available...

Genomic Clones (27)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (12)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0264006

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Jepson et al., 2012)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

New annotation (CG32132) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

New annotation (CG32131) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG17368 CG8760 CG32131

(FlyBase Genome Annotators, 2007)

Source for merge of: CG32131 anon-AE003536.1

(FlyBase, 1996-)

Source for merge of: CG32132 CG34400

(FlyBase Genome Annotators, 2012)

Additional comments

Annotations CG32132 and CG34400 merged as CG43749 in release 5.44 of the genome annotation.

(FlyBase Genome Annotators, 2012)

Annotations CG17368, CG8760 and CG32131 merged as CG34400 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Source for merge of CG32131 anon-AE003536.1 was sequence comparison ( date:030925 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: dysc CG43749

(Jepson et al., 2012)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG17368

(Staudt et al., 2005)

CG32131

CG32132

(Wang et al., 2013, Smibert et al., 2012, Keleman et al., 2009.8.5)

CG34400

(Ashwal-Fluss et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Jepson et al., 2012, Rodriguez et al., 2012, Jungreis et al., 2011, Kucherenko et al., 2011, Marrone et al., 2011, Keleman et al., 2009.8.5, FlyBase Genome Annotators, 2007)

CG43749

(National Institute of Genetics Fly Stocks, 2023-, FlyBase Genome Annotators, 2012)

CG8760

DYSC

(Bodaleo and Gonzalez-Billault, 2016)

Dm_3L:69335

(FlyBase Genome Annotators, 2014, Ladoukakis et al., 2011)

anon-AE003536.1

Name Synonyms

CG17368

CG32131

CG8760

dyschronic

(Li et al., 2018, Jepson et al., 2012)

Secondary FlyBase IDs

FBgn0052132
FBgn0085429
FBgn0043542
FBgn0036384
FBgn0036383
FBgn0052131

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 56 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39533

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

M9PF56

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

M9PF56

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264006

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39533/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264006

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264006

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG43749

MARRVEL_MODEL - MARRVEL (model organism gene)

39533

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0264006

DroID - A comprehensive database of gene and protein interactions.

FBgn0264006

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

dysc_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0264006

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8760

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

MIST (protein-protein) - An integrated Molecular Interaction Database

39533

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

A8JNS6

References (74)

The following external sites may use different assemblies or annotations than FlyBase.

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