FlyBase Gene Report: Dmel\PsGEF

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\PsGEF

General Information

Symbol

Dmel\PsGEF

Species

D. melanogaster

Name

Protostome-specific GEF

Annotation Symbol

CG43947

Feature Type

protein_coding_gene

FlyBase ID

FBgn0264598

Gene Model Status

Stock Availability

14 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

EG:BACH7M4.2 , EG:BACH7M4.1 , EG:BACH48C10.4

Key Links

Genomic Location

Cytogenetic map

Sequence location

X:2,367,121..2,387,664 [-]

Recombination map

1-1

RefSeq locus

NC_004354 REGION:2367121..2387664

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables calcium-dependent phospholipid binding

inferred from sequence model

(Higuchi et al., 2009)

enables guanyl-nucleotide exchange factor activity

inferred from electronic annotation with InterPro:IPR000219

(InterPro Project Members, 2004-)

inferred from sequence model

(Higuchi et al., 2009)

Biological Process (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in mushroom body development

inferred from genetic interaction with FLYBASE:Rac1; FB:FBgn0010333

(Higuchi et al., 2009)

involved_in positive regulation of Rac protein signal transduction

inferred from direct assay

(Higuchi et al., 2009)

involved_in positive regulation of ruffle assembly

inferred from direct assay

(Higuchi et al., 2009)

involved_in regulation of actin filament polymerization

inferred from direct assay

(Higuchi et al., 2009)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Higuchi et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN005323174

(GO Reference Genome Project, 2011-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN005323174

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS -: RhoGEFs are Guanine Nucleotide Exchange Factors (GEFs) for Rho family GTPases. They include Dbl-homology domain-containing proteins (the largest family of RhoGEFs) and CZH2 domain/Dock family GEFs. (Adapted from FBrf0190957).

Gene Model and Products

Number of Transcripts

8

Number of Unique Polypeptides

8

Please see the JBrowse view of Dmel\PsGEF for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7KVY9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0333526

6966

1529

FBtr0333527

2838

786

FBtr0333528

6858

1493

FBtr0333529

9439

2777

FBtr0333530

9913

2738

FBtr0333531

9605

2033

FBtr0333532

9240

2006

FBtr0333533

6425

1403

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0305706

166.0

1529

7.56

FBpp0305707

84.0

786

9.62

FBpp0305708

162.0

1493

7.49

FBpp0305709

297.7

2777

7.41

FBpp0305710

293.2

2738

7.32

FBpp0305711

219.9

2033

6.81

FBpp0305712

216.6

2006

6.98

FBpp0305713

153.2

1403

8.84

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PsGEF using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

PsGEF_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.75

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Higuchi et al., 2009)

Expression Deduced from Reporters

Reporter: P{GawB}NP3237

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15

larval ventral nerve cord | restricted

(Higuchi et al., 2009)

embryonic brain | restricted

(Higuchi et al., 2009)

embryonic/larval midgut

Comment: fusion point

(Higuchi et al., 2009)

adult optic lobe

(Higuchi et al., 2009)

adult antennal lobe

(Higuchi et al., 2009)

adult mushroom body

(Higuchi et al., 2009)

Reporter: P{GawB}NP3316

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15

larval ventral nerve cord | restricted

(Higuchi et al., 2009)

embryonic brain | restricted

(Higuchi et al., 2009)

embryonic/larval midgut

Comment: fusion point

(Higuchi et al., 2009)

adult optic lobe

(Higuchi et al., 2009)

adult antennal lobe

(Higuchi et al., 2009)

adult mushroom body

(Higuchi et al., 2009)

Reporter: P{GawB}NP3612

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15

larval ventral nerve cord | restricted

(Higuchi et al., 2009)

embryonic brain | restricted

(Higuchi et al., 2009)

embryonic/larval midgut

Comment: fusion point

(Higuchi et al., 2009)

adult optic lobe

(Higuchi et al., 2009)

adult antennal lobe

(Higuchi et al., 2009)

adult mushroom body

(Higuchi et al., 2009)

Reporter: P{GawB}NP5114

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15

larval ventral nerve cord | restricted

(Higuchi et al., 2009)

embryonic brain | restricted

(Higuchi et al., 2009)

embryonic/larval midgut

Comment: fusion point

(Higuchi et al., 2009)

adult optic lobe

(Higuchi et al., 2009)

adult antennal lobe

(Higuchi et al., 2009)

adult mushroom body

(Higuchi et al., 2009)

Reporter: P{GawB}NP7169

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15

larval ventral nerve cord | restricted

(Higuchi et al., 2009)

embryonic brain | restricted

(Higuchi et al., 2009)

embryonic/larval midgut

Comment: fusion point

(Higuchi et al., 2009)

adult optic lobe

(Higuchi et al., 2009)

adult antennal lobe

(Higuchi et al., 2009)

adult mushroom body

(Higuchi et al., 2009)

Reporter: P{GawB}NP7265

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15

larval ventral nerve cord | restricted

(Higuchi et al., 2009)

embryonic brain | restricted

(Higuchi et al., 2009)

embryonic/larval midgut

Comment: fusion point

(Higuchi et al., 2009)

adult optic lobe

(Higuchi et al., 2009)

adult antennal lobe

(Higuchi et al., 2009)

adult mushroom body

(Higuchi et al., 2009)

Reporter: P{GawB}PsGEF^NP0264

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15

larval ventral nerve cord | restricted

(Higuchi et al., 2009)

embryonic brain | restricted

(Higuchi et al., 2009)

embryonic/larval midgut

Comment: fusion point

(Higuchi et al., 2009)

adult optic lobe

(Higuchi et al., 2009)

adult antennal lobe

(Higuchi et al., 2009)

adult mushroom body

(Higuchi et al., 2009)

Reporter: P{GawB}PsGEF^NP1088

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15

larval ventral nerve cord | restricted

(Higuchi et al., 2009)

embryonic brain | restricted

(Higuchi et al., 2009)

embryonic/larval midgut

Comment: fusion point

(Higuchi et al., 2009)

adult optic lobe

(Higuchi et al., 2009)

adult antennal lobe

(Higuchi et al., 2009)

adult mushroom body

(Higuchi et al., 2009)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\PsGEF in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\PsGEF

View exonic expression by tissue for Dmel\PsGEF

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264598

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31224/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264598

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264598

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of PsGEF

Transgenic constructs containing regulatory region of PsGEF

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

(Ryder, 2004.4.26)

Inferred from location ( 10 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Sterility

Allele

Other Phenotypes

Allele

abnormal neuroanatomy

PsGEF^Δ21

abnormal neuroanatomy | somatic clone

PsGEF^Δ21

Phenotype manifest in

Allele

adult mushroom body alpha-lobe

PsGEF^Δ21

adult mushroom body alpha-lobe | somatic clone

PsGEF^Δ21

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (39)

2 of 14

Yes

No

2 of 14

Yes

No

2 of 14

Yes

No

1 of 14

No

No

1 of 14

No

No

2

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

Hsap\SYNJ2BP-COX16

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (32)

2 of 14

Yes

No

2 of 14

Yes

No

2 of 14

Yes

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

Mus musculus (laboratory mouse) (39)

2 of 14

Yes

No

2 of 14

Yes

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

Xenopus tropicalis (Western clawed frog) (15)

1 of 13

Yes

Yes

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

No

1 of 13

Yes

Yes

1 of 13

Yes

Yes

Danio rerio (Zebrafish) (31)

2 of 14

Yes

No

2 of 14

Yes

No

Drer\si:dkey-276j7.2

2 of 14

Yes

No

2 of 14

Yes

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Drer\arhgef10la

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Drer\si:ch73-40i7.5

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Caenorhabditis elegans (Nematode, roundworm) (18)

1 of 14

Yes

Yes

1 of 14

Yes

Yes

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

Yes

1 of 14

Yes

Yes

1 of 14

Yes

Yes

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

Yes

1 of 14

Yes

No

1 of 14

Yes

Yes

1 of 14

Yes

Yes

1 of 14

Yes

Yes

1 of 14

Yes

Yes

1 of 14

Yes

No

Anopheles gambiae (African malaria mosquito) (32)

Agam\AgaP_AGAP004701

3 of 12

Yes

Yes

Agam\AgaP_AGAP000054

1 of 12

No

No

Agam\AgaP_AGAP000121

1 of 12

No

No

Agam\AgaP_AGAP000209

1 of 12

No

No

Agam\AgaP_AGAP000449

1 of 12

No

No

Agam\AgaP_AGAP000452

1 of 12

No

No

Agam\AgaP_AGAP000869

1 of 12

No

No

Agam\AgaP_AGAP002145

1 of 12

No

No

Agam\AgaP_AGAP002322

1 of 12

No

No

Agam\AgaP_AGAP002323

1 of 12

No

No

Agam\AgaP_AGAP003604

1 of 12

No

No

Agam\AgaP_AGAP003854

1 of 12

No

No

Agam\AgaP_AGAP004323

1 of 12

No

No

Agam\AgaP_AGAP004702

1 of 12

No

Yes

Agam\AgaP_AGAP005235

1 of 12

No

No

Agam\AgaP_AGAP006605

1 of 12

No

No

Agam\AgaP_AGAP007108

1 of 12

No

No

Agam\AgaP_AGAP007865

1 of 12

No

No

Agam\AgaP_AGAP008221

1 of 12

No

No

Agam\AgaP_AGAP008384

1 of 12

No

No

Agam\AgaP_AGAP009569

1 of 12

No

Yes

Agam\AgaP_AGAP009630

1 of 12

No

Yes

Agam\AgaP_AGAP010413

1 of 12

No

No

Agam\AgaP_AGAP010776

1 of 12

No

No

Agam\AgaP_AGAP010778

1 of 12

No

No

Agam\AgaP_AGAP010808

1 of 12

No

No

Agam\AgaP_AGAP011138

1 of 12

No

No

Agam\AgaP_AGAP011205

1 of 12

No

Yes

Agam\AgaP_AGAP012008

1 of 12

No

No

Agam\AgaP_AGAP012354

1 of 12

No

No

Agam\AgaP_AGAP013193

1 of 12

No

No

Agam\AgaP_AGAP013265

1 of 12

No

No

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:PsGEF. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (30)

2 of 13

a

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Higuchi et al., 2009)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0264598

MIST (protein-protein) - An integrated Molecular Interaction Database

31224

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

E1JJB8

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

X

Recombination map

1-1

Cytogenetic map

Sequence location

X:2,367,121..2,387,664 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

3A2-3A2

Limits computationally determined from genome sequence between P{EP}EP1605 and P{EP}CG32796^EP1385&P{EP}EP1160

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-1

(FlyBase, 2016)

1-0.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

18039

PBac{RB}PsGEF^e02316 w¹¹¹⁸

36343

y¹ PsGEF^Δ21 w^* P{neoFRT}19A

36344

y¹ PsGEF^Δ55 w^* P{neoFRT}19A

97596

TI{CRIMIC.TG4.2}PsGEF^{CR02753-TG4.2} w^*

33433

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00320}attP2

112116

y^* P{GawB}PsGEF^NP0264 w^* / FM7c

112497

y^* P{GawB}PsGEF^NP1088 w^* / FM7c

14045R-1

14045R-2

HMS00320

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00320}attP2

v109769

P{KK103731}VIE-260B

v19902

w¹¹¹⁸; P{GD5199}v19902

More stocks available...

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (12)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE74757

Other clones

IP15173

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0264598

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: EG:BACH7M4.1 CG14045

(FlyBase, 1996-)

Source for merge of: CG14045 EG:BACH7M4.2

(FlyBase, 1996-)

Source for merge of: EG:BACH48C10.4 CG14047

(FlyBase, 1996-)

Source for merge of: CG14047 PsGEF

(FlyBase Genome Annotators, 2012)

Additional comments

Annotations CG14045 and CG14047 merged as CG43947 in release 5.46 of the genome annotation. Merge supported by RNA-seq junction data.

(FlyBase Genome Annotators, 2012)

Source for merge of EG:BACH7M4.1 CG14045 was sequence comparison ( date:000425 ).

(FlyBase, 1996-)

Source for merge of EG:BACH48C10.4 CG14047 was sequence comparison ( date:000425 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: PsGEF CG14045

(Higuchi et al., 2009)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

CG14045

(Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2010.12.1, Higuchi et al., 2009, Jones et al., 2009, Keleman et al., 2009.8.5, Bakal et al., 2007, Legube et al., 2006, Greene et al., 2005, Adolfsen and Littleton, 2001)

CG14047

(Hosono et al., 2015, Ashwal-Fluss et al., 2014, Baranov et al., 2011, Wasbrough et al., 2010, Higuchi et al., 2009, Stark et al., 2007)

CG43947

(FlyBase Genome Annotators, 2012, Ni et al., 2010.12.1)

DmPsGEF

(Higuchi et al., 2009)

EG:BACH48C10.4

(Benos et al., 2001, Benos, 1999.12.16)

EG:BACH7M4.1

(Bolshakov et al., 2002, Benos et al., 2001, Ashburner and Benos, 2000.5.16, Benos, 2000.12.13, Benos, 1999.12.16)

EG:BACH7M4.2

(Benos et al., 2001, Ashburner and Benos, 2000.5.16, Benos, 2000.12.13, Whitfield, 2000.10.30, Benos, 1999.12.16)

FBgn0264598

PsGEF

(Qu et al., 2024, di Pietro et al., 2023, Pang et al., 2021, Yanagawa et al., 2020, Gene Disruption Project members, 2018-, Rodriguez et al., 2012, Higuchi et al., 2009)

PsGef

(Aranjuez et al., 2012)

null

psGEF

(Campbell et al., 2018)

Name Synonyms

CG14045

Protostome-specific GEF

protostome-specific GEF

(Higuchi et al., 2009)

Secondary FlyBase IDs

FBgn0040387
FBgn0029616
FBgn0040386
FBgn0040390
FBgn0029615

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 103 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31224

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7KVY9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7KVY9

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264598

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31224/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264598

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264598

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG43947

MARRVEL_MODEL - MARRVEL (model organism gene)

31224

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0264598

DroID - A comprehensive database of gene and protein interactions.

FBgn0264598

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

PsGEF_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0264598

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC030997

MIST (protein-protein) - An integrated Molecular Interaction Database

31224

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

E1JJB8

References (55)