scaffolding protein - PDZ domain protein - involved in visual signal transduction
Please see the JBrowse view of Dmel\inaD for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.52
2 (northern blot)
None of the polypeptides share 100% sequence identity.
674 (aa); 90 (kD observed); 80 (kD predicted)
Interacts with the C-terminus of trp, and with norpA and inaC to form the inaD signaling complex. Interacts with Fkbp59, which together with trpl, rhodopsin and calmodulin may also be part of the inaD complex.
Phosphorylated by inaC.
Second PDZ domain is a type I PDZ domain that tethers type I PDZ ligand inaC by interaction with its C-terminus.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\inaD using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
inaD protein is detected exclusively in the retina of the eye. It is expressed in photoreceptor cells and in the ocelli. In ultrathin sections of photoreceptor cells, most of the protein is associated with rhabdomeres.
JBrowse - Visual display of RNA-Seq signals
View Dmel\inaD in JBrowse
2-101
2-106.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
inaD functions as a master scaffold for subcellular compartmentalization of the phototransduction machinery.
A novel tripeptide motif in the C terminus of norpA associates with inaD. Expression of transgenic norpA that displays no interaction with inaD reveals abnormal ERG with slow kinetics suggesting the association between inaD and norpA is important in the regulation of activation and deactivation of visual transduction.
The inaD protein is composed of five distinct PDZ domains and acts as an organising scaffold for photoreceptor signalling complexes in vivo.
