myosin III, Nina C, DRONINAC
motor domain protein involved in adaptation during visual signal transduction - regulates of translocation of Arrestin2 - required for stability of INAD and PKC
Please see the JBrowse view of Dmel\ninaC for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
5, 4 (northern blot)
1501, 1135 (aa); 174, 132 (kD observed)
Interacts with rtp.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ninaC using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.
JBrowse - Visual display of RNA-Seq signals
View Dmel\ninaC in JBrowse2-26
2-24.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Mutation rate at microsatellite loci in 119 lines maintained for approximately 250 generations is estimated to be 6.3x10-6, at least one order of magnitude lower than the mutation rate in mammals.
Using whole-cell recording and measurements of the pupil mechanisms the p174 protein of ninaC is suggested to be required for normal termination of the transduction cascade.
ninaC protein does exhibit protein kinase activity.
Both Ca2+-dependent binding sites in the ninaC calmodulin binding domain are required for normal calmodulin distribution in vivo and for phototransduction. The electrophysiological phenotype resulting from mutation of the binding sites indicates the p174-calmodulin interaction has a role in the termination of the photoresponse.
The calcium content of light and dark raised flies demonstrates that calcium accumulation is a secondary effect, rather than primary effect, in the degeneration process.
Two different phylogenetic methods used to analyse all available myosin head sequences: there are at least three equally divergent classes of myosin, demonstrating that the current classification into two classes needs to be reexamined.
Major opsin genes can be transcribed in the absence of carotenoid, or retinoid. Expression of mature opsin is extremely depressed by carotenoid deprivation. The chromophore 11-cis-3-hydroxyretinal accelerates the synthesis of opsin by inducing its maturation.
Mutations affect eye morphology.
ninaC is required for maintenance of the rhabdomeres during light and for normal phototransduction.
ninaC gene product is a regulatory protein that modulates the activity of other proteins important in phototransduction by phosphorylation.
Decreased rhodopsin content is due to reduction in diameter of the rhabdomeres; the microvilli are shorter than normal and have reduced cytoskeletal electron-dense regions.
