Myosin VI, Mhc95F, 95F myosin, MyoVI, 95F unconventional myosin
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.47
Gene model reviewed during 6.02
4.7, 4.5-4.7 (northern blot)
1268, 1253, 1078 (aa); 145, 140, 120 (kD)
The jar protein isoforms differ only at the carboxy-terminal end. All are related to other myosin proteins in the head region. No sequences in the database are related to the tail regions.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\jar using the Feature Mapper tool.
jar protein is observed in a punctate pattern throughout the cortical cytoplasm.
jar protein is detected in the border cells in stage 9 developing oocytes. The protein is expressed during border cell migration during the first 6 hours of stage 9. Expression of jar protein is also detected in all the follicle cells starting in mid stage 9 and persisting through stage 10.
GBrowse - Visual display of RNA-Seq signalsView Dmel\jar in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
didum acts to interrupt mitochondrial transport on microtubules to decrease the duty cycle and perhaps facilitate docking in retrograde transport.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
jar is necessary for basal protein targeting and spindle orientation in dividing embryonic neuroblasts.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
jar associates with cytoplasmic particles that undergo cell cycle- dependent translocations. In interphase these particles are in cytoplasmic domains surrounding the nuclei near the syncytial blastoderm, during mitosis the particles associate with transient actin rich membrane invaginations that separate neighbouring nuclei. Time lapse computational optical sectioning microscopy has shown directed transport of the particles. The transport is actin based, ATP-dependent and is disrupted by a jar specific antibody.
Actin based, ATP-dependent linear transport of cytoplasmic particles in syncytial blastoderm embryos can be visualised by antibodies and is catalysed by the unconventional myosin jar.
Postmeiotic differentiation defect.