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Citation
Millo, H., Leaper, K., Lazou, V., Bownes, M. (2004). Myosin VI plays a role in cell-cell adhesion during epithelial morphogenesis.  Mech. Dev. 121(11): 1335--1351.
FlyBase ID
FBrf0183217
Publication Type
Research paper
Abstract

Myosin VI is an unconventional Myosin that has been implicated in vesicle transport and membrane trafficking. We isolated lethal mutants of Myosin VI, which lack protein once maternal supplies have been utilised during embryogenesis. Dorsal closure, where there is a ring of Myosin VI at the edge of the migrating epithelial sheet, is often abnormal. The sheet of migrating cells is irregular, rather than a smooth epithelium and cells begin to detach. Some embryos hatch into larvae, containing detached cells loose in the haemolymph. Myosin VI is crucial for correct cell morphology and maintenance of adhesive cellular contacts within epithelial cell layers.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mech. Dev.
    Title
    Mechanisms of Development
    Publication Year
    1990-
    ISBN/ISSN
    0925-4773
    Data From Reference
    Aberrations (1)
    Alleles (12)
    Genes (10)
    Insertions (5)
    Experimental Tools (2)
    Transgenic Constructs (3)