FlyBase Allele Report: Dmel\jar[R39]

General Information

Symbol

Dmel\jar^R39

Species

D. melanogaster

Name

FlyBase ID

FBal0175641

Feature type

allele

Associated gene

Dmel\jar

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Millo et al., 2004)

Progenitor genotype

jar^C865

(Millo et al., 2004)

Cytology

Description

Imprecise excision of the P{GawB} element. Sequence from 347 to 340bp upstream of the first jar exon is deleted, while sequence from 341 to 322bp upstream of the first jar exon is duplicated.

(Millo et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | embryonic stage (with jar^R235)

(Millo et al., 2004)

lethal | larval stage (with jar^R235)

(Millo et al., 2004)

lethal | recessive

(Millo et al., 2004)

male sterile (with jar^mmw14)

(Millo and Bownes, 2007, Millo et al., 2004)

Phenotype Manifest In

amnioserosa & actin filament

(Millo et al., 2004)

embryo | dorsal closure stage

(Millo et al., 2004)

embryo | dorsal closure stage (with jar^R235)

(Millo et al., 2004)

embryonic leading edge cell

(Millo et al., 2004)

Detailed Description

Statement

Reference

Many jar^R235/jar^R39 embryos fail to complete dorsal closure. Those which complete dorsal closure die during the first larval instar. Germband retraction is incomplete in some jar^R235/jar^R39 embryos. Homozygous embryos fail to complete dorsal closure, resulting in embryos with exposed yolk and loose cells escaping. The cells of the amnioserosa are detached. In some embryos that fail to complete dorsal closure, the actin filaments of the amnioserosa are disassociated. At the leading edge, some regions of the actin cable are destroyed, many of the cells are not elongated and the organisation of the row of cells at the front of the leading edge is disrupted. Cells with aberrant shape are also seen in the border regions between segments.

(Millo et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

jar^R235

(Millo et al., 2004)

jar^mmw14

(Millo et al., 2004)

Rescued by

jar^mmw14/jar^R39 is rescued by Scer\GAL4^Pisd-R39/jar^UAS.EGFP

(Millo and Bownes, 2007)

jar^R39 is rescued by jar^UAS.EGFP/Scer\GAL4^e22c

(Millo et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Induced with: CG5991^R39.

(Millo et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

jar^R39

(Millo and Bownes, 2007)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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