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FB2021_04, released August 17, 2021

Gene: Dmel\d

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General Information
Symbol
Dmel\d
Species
D. melanogaster
Name
dachs
Annotation Symbol
CG42840
Feature Type
protein_coding_gene
FlyBase ID
FBgn0262029
Gene Model Status
Current
Stock Availability
17 publicly available
Gene Summary
dachs (d) encodes a myosin family protein that participates in Dachsous-Fat signaling, which polarizes its localization. It influences planar cell polarity, partly through interaction with the product of pk, and growth, through interaction with the product of wts. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Myo29D

Key Links
Genomic Location
Cytogenetic map
29D1-29D1
Sequence location
2L:8,466,817..8,488,671 [+]
Recombination map
2-33
RefSeq locus
NT_033779 REGION:8466817..8488671
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (22 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables actin filament binding
inferred from direct assay
(Cao et al., 2014)
enables protein binding
inferred from physical interaction with UniProtKB:Q9VUV7
(assigned by UniProt )
(Misra and Irvine, 2019)
inferred from physical interaction with UniProtKB:A1ZAY1
(assigned by UniProt )
(Zhang et al., 2016)
inferred from physical interaction with FLYBASE:Zyx; FB:FBgn0011642
(Cao et al., 2014)
NOT enables ATP binding
inferred from direct assay
(Cao et al., 2014)
NOT enables ATP hydrolysis activity
inferred from direct assay
(Cao et al., 2014)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables motor activity
inferred from electronic annotation with InterPro:IPR001609
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
NOT enables microfilament motor activity
inferred by curator from GO:0005524,GO:0016887
(Cao et al., 2014)
Biological Process (11 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
involved_in establishment of ommatidial planar polarity
inferred from mutant phenotype
(Mao et al., 2006)
involved_in establishment of planar polarity
inferred from mutant phenotype
(Misra and Irvine, 2016, Bosveld et al., 2012)
involved_in imaginal disc-derived wing vein morphogenesis
inferred from mutant phenotype
(Mao et al., 2006)
involved_in leg disc development
inferred from mutant phenotype
(Mao et al., 2006)
involved_in negative regulation of hippo signaling
inferred from genetic interaction with FLYBASE:hpo; FB:FBgn0261456
(Zhang et al., 2016)
inferred from mutant phenotype
(Misra and Irvine, 2016)
involved_in positive regulation of growth
inferred from mutant phenotype
(Mao et al., 2006)
involved_in positive regulation of imaginal disc growth
inferred from mutant phenotype
(Rauskolb et al., 2011)
involved_in protein localization involved in establishment of planar polarity
inferred from direct assay
(Misra and Irvine, 2016)
involved_in wing disc development
inferred from mutant phenotype
(Mao et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in actin filament organization
inferred from biological aspect of ancestor with PANTHER:PTN000320364
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in vesicle transport along actin filament
inferred from biological aspect of ancestor with PANTHER:PTN000320364
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in apicolateral plasma membrane
inferred from direct assay
(Misra and Irvine, 2016)
located_in cytosol
inferred from direct assay
(Mao et al., 2006)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in actin cytoskeleton
inferred from biological aspect of ancestor with PANTHER:PTN000320364
(assigned by GO_Central )
(Gaudet et al., 2011)
part_of myosin complex
inferred from electronic annotation with InterPro:IPR001609
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
is_active_in vesicle
inferred from biological aspect of ancestor with PANTHER:PTN000320364
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
dachs (d) encodes a myosin family protein that participates in Dachsous-Fat signaling, which polarizes its localization. It influences planar cell polarity, partly through interaction with the product of pk, and growth, through interaction with the product of wts. [Date last reviewed: 2019-03-07]
Pathway (FlyBase)
Negative Regulators of Hippo Signaling Pathway -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Negative regulators of the pathway promote the nuclear accumulation of yki, enhancing yki-mediated transcriptional regulation and the expression of genes that positively regulate tissue growth (Adapted from FBrf0224870).
Gene Group (FlyBase)
NON-MOTOR MYOSINS -
Non-motor myosins include class XX and XVIIIa myosins, which belong to the myosin superfamily but lack ATP-binding/ATPase activity and do not function as molecular motors. They are able to bind actin and are though to act as scaffold or actin tethering proteins. (Adapted from FBrf0213876 and FBrf0223842.)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
d: dachs
Similar to fj. Tarsi four jointed instead of five jointed owing to failure of joint formation between second and third tarsal segments (Tokunaga and Gerhart, 1976, Genetics 83: s76); joint remnants sometimes persist beneath the cuticle (Held, Duarte, and Derakhshanian, 1986, Wilhelm Roux's Arch. Dev. Biol. 195: 145-57). Legs short and held close to body. Femur, tibia, and tarsae foreshortened [Tokunaga and Gerhart; Mikuta and Mglinetz, 1979, Genetika (Moscow) 15: 624-32]. Probability of failure of joint formation proportional to degree of foreshortening of second tarsal segment (Tokunaga and Gerhart). Joint failure phenotype can extend into d/+ tissue adjacent to d/d clones (Tokunaga and Gerhart). Number of longitudinal rows of bristles in second basitarsus unaffected, but number of bristles per row reduced (Held, 1979, Wilhelm Roux's Arch. Dev. Biol. 187: 105-27). Leg effects enhanced by ssa and ssaB (Villee, 1945, Genetics 30: 26-27). Wings smaller than wild type, narrowed, with L2 and L3 joined near anterior crossvein; distance between crossveins smaller and crossveins sometimes absent. Angle between L2 and L5 greater than normal. Eyes small and rough. Posterior scutellar bristles erect. Viability erratic. Frequently sterile. Enhances transforming effects of AntpNs (Mikuta and Mglinetz, 1979) and pb; labial legs in d; pb flies show failure of joint formation [Kaurov, 1978, Genetika (Moscow) 14: 306-12]. RK2.
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\d for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.40

Gene model reviewed during 5.45

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
d-RD
FBtr0303923
NM_001201800
5120
1244
d-RE
FBtr0303924
NM_001201801
5093
1426
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
d-PD
FBpp0292924
135.4
1244
9.75
NP_001188729
ADV36979
d-PE
FBpp0292925
155.8
1426
9.28
NP_001188730
ADV36980
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\d using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in apicolateral plasma membrane
inferred from direct assay
(Misra and Irvine, 2016)
located_in cytosol
inferred from direct assay
(Mao et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\d in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 24 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of d
Transgenic constructs containing regulatory region of d
Aberrations (Deficiencies and Duplications) ( 6 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
FlyBase_internaltransgene_features:cell lethal:cell lethal | somatic clone
lethal
lethal | recessive
lethal - all die before end of P-stage
partially lethal - majority die, with Scer\GAL4pnr-MD237
partially lethal - majority live
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
fertile
semi-fertile
Other Phenotypes
Allele
abnormal cell polarity
abnormal planar polarity
abnormal planar polarity, with Scer\GAL4unspecified
abnormal planar polarity (with Df(2L)ED623)
abnormal planar polarity | adult stage (with d1)
abnormal planar polarity | adult stage (with dGC13)
abnormal size
abnormal size, with Scer\GAL4Bx-MS1096
abnormal size, with Scer\GAL4nub-AC-62
abnormal size | adult stage, with Scer\GAL4en-e16E
abnormal size | adult stage, with Scer\GAL4nub.PU
decreased cell number
hyperplasia | adult stage, with Scer\GAL4hh.PU
hyperplasia | adult stage, with Scer\GAL4Tub.PU
hypoplasia | adult stage, with Scer\GAL4Tub.PU
some die during pharate adult stage
some die during pupal stage, with Scer\GAL4pnr-MD237
visible
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4Tub.PU
visible (with d210)
visible (with dGC13)
visible (with Df(2L)ED623)
visible (with Df(2L)N22-5)
visible | adult stage, with Scer\GAL4en-e16E
visible | adult stage, with Scer\GAL4hh.PU
visible | adult stage, with Scer\GAL4Tub.PU
visible | adult stage | somatic clone
Phenotype manifest in
Allele
abdominal tergite marginal bristle (with d210)
abdominal tergite marginal bristle (with dGC13)
adult abdomen (with Df(2L)ED623)
anterior crossvein (with d1)
anterior crossvein (with d210)
anterior crossvein (with Df(2L)N22-5)
crossvein
crossvein, with Scer\GAL4Tub.PU
crossvein (with d1)
crossvein (with dGC13)
crossvein | ectopic (with d1)
crossvein | ectopic (with d210)
crossvein | ectopic (with Df(2L)N22-5)
crossvein | somatic clone
eye
eye | adult stage | somatic clone
eye disc | third instar larval stage (with d1)
eye disc | third instar larval stage (with dGC13)
femur
leg
leg, with Scer\GAL4Tub.PU
leg (with d210)
leg (with dGC13)
leg (with Df(2L)ED623)
leg | somatic clone
leg sensillum
mesothoracic tarsal bristle longitudinal row
mesothoracic tergum, with Scer\GAL4pnr-MD237
metathoracic tarsal bristle longitudinal row
ommatidium
ommatidium | somatic clone
posterior scutellar bristle
prothoracic tarsal bristle longitudinal row
scutellum, with Scer\GAL4unspecified
tarsal segment
tarsal segment | somatic clone
tibia
trichogen cell, with Scer\GAL4pnr-MD237
ventral thoracic disc
wing
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4nub.PU
wing, with Scer\GAL4nub-AC-62
wing, with Scer\GAL4Tub.PU
wing (with Df(2L)N22-5)
wing | posterior, with Scer\GAL4en-e16E
wing | proximal (with d1)
wing | proximal (with dGC13)
wing blade, with Scer\GAL4Tub.PU
wing disc | conditional
wing disc | third instar larval stage (with d1)
wing disc | third instar larval stage (with dGC13)
wing hair
wing hair (with d1)
wing hair (with dGC13)
wing hair (with Df(2L)ED623)
wing posterior compartment, with Scer\GAL4hh.PU
wing vein
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\MYO5A
2 of 15
Yes
No
Hsap\MYO5B
2 of 15
Yes
No
Hsap\MYO5C
2 of 15
Yes
No
Hsap\MYO19
2 of 15
Yes
No
Hsap\ASPM
1 of 15
No
No
Hsap\IQCB1
1 of 15
No
Yes
Hsap\MYH10
1 of 15
No
No
Hsap\MYO1G
1 of 15
No
No
Hsap\RADIL
1 of 15
No
Yes
Hsap\RASIP1
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Myo5a
2 of 15
Yes
No
Mmus\Myo5b
2 of 15
Yes
No
Mmus\Myo5c
2 of 15
Yes
No
Mmus\Myo19
2 of 15
Yes
No
Mmus\Aspm
1 of 15
No
No
Mmus\Iqcb1
1 of 15
No
Yes
Mmus\Myh10
1 of 15
No
No
Mmus\Myo1g
1 of 15
No
No
Mmus\Myo16
1 of 15
No
Yes
Mmus\Radil
1 of 15
No
Yes
Mmus\Rasip1
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (9)
Rnor\Myo5b
2 of 13
Yes
No
Rnor\Myo5c
2 of 13
Yes
No
Rnor\Myo19
2 of 13
Yes
No
Rnor\Aspm
1 of 13
No
No
Rnor\Iqcb1
1 of 13
No
Yes
Rnor\Myh10
1 of 13
No
No
Rnor\Myo5a
1 of 13
No
No
Rnor\Radil
1 of 13
No
Yes
Rnor\Rasip1
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (7)
Xtro\myo5a
2 of 12
Yes
No
Xtro\myo5b
2 of 12
Yes
No
Xtro\myo19
2 of 12
Yes
No
Xtro\iqcb1
1 of 12
No
Yes
Xtro\myh10
1 of 12
No
No
Xtro\myo5c
1 of 12
No
No
Xtro\rasip1
1 of 12
No
Yes
Danio rerio (Zebrafish) (9)
Drer\myo5aa
2 of 15
Yes
No
Drer\myo5ab
2 of 15
Yes
No
Drer\myo5b
2 of 15
Yes
No
Drer\myo5c
2 of 15
Yes
No
Drer\myo19
2 of 15
Yes
No
Drer\si:dkey-110c1.10
2 of 15
Yes
No
Drer\iqcb1
1 of 15
No
Yes
Drer\radil
1 of 15
No
Yes
Drer\rasip1
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\hum-2
2 of 15
Yes
No
Cele\hum-4
1 of 15
No
No
Cele\hum-10
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (17)
Atha\MYA2
2 of 9
Yes
No
Atha\XIA
2 of 9
Yes
No
Atha\XIB
2 of 9
Yes
No
Atha\XID
2 of 9
Yes
No
Atha\XIG
2 of 9
Yes
No
Atha\XIH
2 of 9
Yes
No
Atha\ATM1
1 of 9
No
No
Atha\ATM2
1 of 9
No
No
Atha\MYA1
1 of 9
No
No
Atha\VIIIA
1 of 9
No
No
Atha\VIIIB
1 of 9
No
No
Atha\XIC
1 of 9
No
No
Atha\XIE
1 of 9
No
No
Atha\XIF
1 of 9
No
No
Atha\XI-I
1 of 9
No
No
Atha\XIJ
1 of 9
No
No
Atha\XIK
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\MYO2
1 of 15
Yes
No
Scer\MYO4
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900XN )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000347
Drosophila simulans
Dsim\GD23548
Drosophila sechellia
Dsec\GM16990
Drosophila erecta
Dere\GG25288
Drosophila yakuba
Dyak\GE18779
Drosophila ananassae
Dana\GF15530
Drosophila pseudoobscura pseudoobscura
Dpse\GA25301
Drosophila persimilis
Dper\GL26131
Drosophila willistoni
Dwil\GK24173
Drosophila virilis
Dvir\GJ18028
Drosophila mojavensis
Dmoj\GI10421
Drosophila grimshawi
Dgri\GH10957
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500RH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17020862
Glossina morsitans
Tsetse fly
Gmor\GMOY000852
Mayetiola destructor
Hessian fly
Mdes\Mdes006863
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012449
Anopheles darlingi
American malaria mosquito
Adar\ADAC004312
Anopheles gambiae
Malaria mosquito
Agam\AGAP009933
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ017570
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01BC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA004656
Danaus plexippus
Monarch butterfly
Dple\DPOGS212363-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL005306
Apis florea
Little honeybee
Aflo\3249584068
Apis mellifera
Western honey bee
Amel\GB54226
Apis mellifera
Western honey bee
Amel\GB44231
Apis mellifera
Western honey bee
Amel\GB55735
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10765
Bombus terrestris
Buff-tailed bumblebee
Bter\15213454
Linepithema humile
Argentine ant
Lhum\LH20569
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000067
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000223
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04455
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04448
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04449
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04454
Tribolium castaneum
Red flour beetle
Tcas\TC032522
Pediculus humanus
Human body louse
Phum\PHUM205430
Rhodnius prolixus
Kissing bug
Rpro\RPRC009834
Cimex lectularius
Bed bug
Clec\CLEC012615
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI071965
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15653
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00WI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR001509
Ixodes scapularis
Black-legged tick
Isca\ISCW009513
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58641.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58637.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur26g00140
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_40739
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01EG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-MyXII
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-MyXII_1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (15)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
didum
4 of 10
ck
2 of 10
jar
2 of 10
Myo10A
2 of 10
Myo28B1
2 of 10
Myo31DF
2 of 10
Myo61F
2 of 10
Myo95E
2 of 10
CG31638
1 of 10
CG43796
1 of 10
Mhcl
1 of 10
Mhc
1 of 10
Myo81F
1 of 10
Prm
1 of 10
zip
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    dGC13
    ameliorates  dentatorubral-pallidoluysian atrophy
    modeled by Gug75QN.UAS
    (Napoletano et al., 2011)
    ameliorates  neurodegenerative disease
    modeled by ft8
    (Napoletano et al., 2011)
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    d - CG8507
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    d - Cam
    anti tag coimmunoprecipitation, peptide massfingerprinting, molecular weight estimation by staining
    (Cao et al., 2014, Kwon et al., 2013)
    d - Cortactin
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    d - Dbct
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    d - Dlish
    anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot, two hybrid, pull down
    (Wang et al., 2019, Misra and Irvine, 2016, Zhang et al., 2016, Kwon et al., 2013)
    d - ERp60
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    d - Fmr1
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    d - Pabp2
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    d - Rcc1
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    d - Ref1
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    d - Rm62
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    d - RpA-70
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    d - Swip-1
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    d - Ubi-p5E
    anti tag coimmunoprecipitation, western blot, anti tag western blot
    (Bosch et al., 2014)
    d - Ubi-p63E
    anti tag coimmunoprecipitation, western blot
    (Bosch et al., 2014)
    d - Vap33
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    d - Ythdc1
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    d - Zyx
    anti tag coimmunoprecipitation, anti tag western blot
    (Cao et al., 2014, Rauskolb et al., 2011)
    d - app
    anti tag coimmunoprecipitation, western blot
    (Matakatsu et al., 2017)
    d - ds
    anti tag coimmunoprecipitation
    (Bosveld et al., 2012)
    d - elgi
    anti tag coimmunoprecipitation, anti tag western blot
    (Misra and Irvine, 2019)
    d - jub
    anti tag coimmunoprecipitation, anti tag western blot
    (Rauskolb et al., 2011)
    d - kst
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    d - pk
    coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot
    (Ambegaonkar and Irvine, 2015, Ayukawa et al., 2014)
    d - pod1
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    d - ref(2)P
    anti tag coimmunoprecipitation, peptide massfingerprinting, western blot
    (Nagai et al., 2021, Kwon et al., 2013)
    d - shrb
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    d - ssx
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    d - sti
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    d - tum
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    d - vig2
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    d - wts
    anti tag coimmunoprecipitation, anti tag western blot
    (Rauskolb et al., 2011, Cho et al., 2006)
    d - α-Spec
    anti tag coimmunoprecipitation, peptide massfingerprinting
    (Kwon et al., 2013)
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    d
    suppressible
    Dlish
    (Zhang et al., 2016)
    d
    enhanceable
    Dlish
    (Misra and Irvine, 2016)
    d
    enhanceable
    Fbxl7
    (Rodrigues-Campos and Thompson, 2014)
    d
    suppressible
    Tao
    (Poon et al., 2011)
    d|ft
    enhanceable
    yki
    (Brittle et al., 2012)
    d
    enhanceable
    Zyx
    (Gaspar et al., 2015, Rauskolb et al., 2011)
    d
    suppressible
    Zyx
    (Rauskolb et al., 2011)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Antp
    enhanceable
    d
    (Mikuta and Mglinetz, 1979)
    app
    suppressible
    d
    (Matakatsu and Blair, 2008)
    cg
    enhanceable
    d
    (Waddington, 1953)
    dco
    suppressible
    d
    (Cho et al., 2006)
    Dlish
    enhanceable
    d
    (Misra and Irvine, 2016)
    ds
    suppressible
    d
    (Brittle et al., 2012)
    Fbxl7
    enhanceable
    d
    (Rodrigues-Campos and Thompson, 2014)
    fj
    enhanceable
    d
    (Buckles et al., 2001)
    ft
    suppressible
    d
    (Brittle et al., 2012, Napoletano et al., 2011, Mao et al., 2006)
    Gug
    suppressible
    d
    (Napoletano et al., 2011)
    pb
    enhanceable
    d
    Zyx
    enhanceable
    d
    (Rauskolb et al., 2011)
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Negative Regulators of Hippo Signaling Pathway -
    The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Negative regulators of the pathway promote the nuclear accumulation of yki, enhancing yki-mediated transcriptional regulation and the expression of genes that positively regulate tissue growth (Adapted from FBrf0224870).
    Metabolic Pathways
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-33
    Cytogenetic map
    29D1-29D1
    Sequence location
    2L:8,466,817..8,488,671 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    29D1-29D1
    Limits computationally determined from genome sequence between P{lacW}l(2)k03706k03706&P{lacW}Acerk07704 and P{PZ}lmg03424
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    29D1-29D1
    (Tzolovsky, 2001.12.3)
    Experimentally Determined Recombination Data
    Location

    2-33

    (FlyBase, 2016)

    2-27.9

    (Comeron et al., 2012)

    2-31.0

    (Goldschmidt, 1944)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (17)
    Genomic Clones (21)
    cDNA Clones (31)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of

    Source for merge of: d l(2)c00146

    (FlyBase, 1996-)

    Source for merge of: d anon- EST:Liang-1.78

    (Tzolovsky et al., 2002)

    Source for merge of: d CG10595

    (FlyBase, 1996-)

    Source for merge of: d CG13087

    (FlyBase Genome Annotators, 2010)
    Additional comments

    unsRNA:d-a is encoded in an intron of d.

    (Graveley et al., 2011)

    Annotations CG10595 and CG13087 merged as CG42840 in release 5.30 of the genome annotation.

    (FlyBase Genome Annotators, 2010)

    Source for merge of d CG10595 was sequence comparison ( date:010908 ).

    (FlyBase, 1996-)
    Other Comments

    The motor domain of d has neither ATPase activity nor the ability to bind ATP in vitro. The motor domain of d binds to F-actin in an ATP-independent manner and enhances the interaction between actin filaments and Zyx in vitro. This suggests that d functions as a scaffold protein, but not as a molecular motor.

    (Cao et al., 2014)

    d acts downstream of ft.

    (Mao et al., 2006)

    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

    (Kiger et al., 2003)

    New annotation (CG31610) in release 3 of the genome annotation. CG31610 merged into CG10595 in release 3 of the genome annotation, October 2002.

    (FlyBase Genome Annotators, 2002-2003)
    Origin and Etymology
    Discoverer

    Morgan and Bridges, 22nd Nov. 1912.

    Etymology
    Identification
    External Crossreferences and Linkouts ( 55 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    DRscDB
    EMBL-EBI Single Cell Expression Atlas
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    FlyMine - An integrated database for Drosophila genomics
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    MARRVEL_MODEL
    modMine - A data warehouse for the modENCODE project
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (22)
    Reported As
    Symbol Synonym
    29C3-D1
    (Oliver et al., 1999)
    29CD
    (Berg et al., 2001)
    AAF52683
    (Yamashita et al., 2000)
    CG10595
    (Petzoldt et al., 2012, Keleman et al., 2009.8.5, Perkins et al., 2009, Mao et al., 2006, Tzolovsky et al., 2002)
    CG13087
    (Ashwal-Fluss et al., 2014, Keleman et al., 2009.8.5)
    CG31610
    CG42840
    (Hosono et al., 2015, FlyBase Genome Annotators, 2010, Ni et al., 2010.12.1)
    D
    (Fulford and McNeill, 2020, Fulford et al., 2018, Richardson and Portela, 2017, Misra and Irvine, 2016, Wittkorn et al., 2015, Bossuyt et al., 2014, Grifoni et al., 2013, Harvey and Hariharan, 2012, Halder and Johnson, 2011, Milton et al., 2010, Hariharan, 2006)
    Dachs
    (Dye et al., 2021, Strutt and Strutt, 2021, Thompson, 2021, Misra and Irvine, 2019, Fallahi et al., 2016, Misra and Irvine, 2016, Irvine and Harvey, 2015, Matsui and Lai, 2013, Liu et al., 2012)
    Dh
    (Gou et al., 2018)
    DmMyo20
    (Cao et al., 2014)
    Ds
    (Pan et al., 2013)
    Myo29D
    (Tzolovsky et al., 2002, Tzolovsky, 2001.12.3)
    Myo3A
    (Kollmar, 2015.9.15)
    anon-EST:Liang-1.78
    clone 1.78
    (Liang and Biggin, 1998)
    d
    (Li and Hidalgo, 2020, Mahmud et al., 2020, Wang et al., 2019, Mangione and Martín-Blanco, 2018, Matakatsu et al., 2017, Misra and Irvine, 2016, Gaspar et al., 2015, Kwon et al., 2015, Okumura et al., 2015, Toshima et al., 2014, Kwon et al., 2013, Kwon et al., 2013, Marcinkevicius and Zallen, 2013, Sharma and McNeill, 2013, Brittle et al., 2012, Singh and Mlodzik, 2012, Bao et al., 2011, Graveley et al., 2011, Jukam and Desplan, 2011, Kawamori et al., 2011, Li et al., 2011, Liu et al., 2011, Napoletano et al., 2011, Reddy et al., 2010, Zecca and Struhl, 2010, Inomata et al., 2008, Matakatsu and Blair, 2008, Yang et al., 2008, Cho et al., 2006, Christensen and Cook, 2006.8.30)
    dachs
    (Montes and Morata, 2017, Su, 2015, Degoutin et al., 2013, Marcinkevicius and Zallen, 2013, Grusche et al., 2011, Feng and Irvine, 2007)
    l(2)c00146
    Name Synonyms
    Dachs
    (Garrido-Jimenez et al., 2019, Gou et al., 2018, Richardson and Portela, 2017, Misra and Irvine, 2016, Wittkorn et al., 2015, Bosch et al., 2014, Bossuyt et al., 2014, Degoutin et al., 2013, Kwon et al., 2013, Lawrence and Casal, 2013, Mao et al., 2013, Pan et al., 2013, Sharma and McNeill, 2013, Yu and Guan, 2013, Ambegaonkar et al., 2012, Ambegaonkar et al., 2012, Fausti et al., 2012, Liu et al., 2012, Singh and Mlodzik, 2012, Bao et al., 2011, Halder and Johnson, 2011, Zhao et al., 2011, Feng and Irvine, 2009)
    dachs
    (Tokamov et al., 2021, Misra and Irvine, 2019, Zhang et al., 2016, Kwon et al., 2015, Okumura et al., 2015, Cao et al., 2014, Rodrigues-Campos and Thompson, 2014, Degoutin et al., 2013, Bosveld et al., 2012, Bosveld et al., 2012, Brittle et al., 2012, Petzoldt et al., 2012, Yue et al., 2012, Goodrich and Strutt, 2011, Jukam and Desplan, 2011, Mao et al., 2011, Poon et al., 2011, Rauskolb et al., 2011, Milton et al., 2010, Reddy et al., 2010, Robinson et al., 2010, Zecca and Struhl, 2010, Matakatsu and Blair, 2008, Rogulja et al., 2008, Willecke et al., 2008, Feng et al., 2007, Cho et al., 2006, Hariharan, 2006, Mao et al., 2006)
    lethal (2) c00146
    myosin 29D
    (Millo et al., 2004)
    unconventional myosin 29D
    (Tzolovsky, 2001.12.3)
    Secondary FlyBase IDs
    • FBgn0032045
    • FBgn0086896
    • FBgn0000410
    • FBgn0025975
    • FBgn0032046
    • FBgn0051610
    • FBgn0069196
    Datasets (1)
    Study focus (1)
    Experimental Role
    Project
    Project Type
    Title
    • bait_protein
    Hippo_Pathway_interaction_map
    Interaction map generated by purification of Hippo pathway factors, with identification of copurifying proteins by mass spectrometry.
    References (169)