FB2026_02 , released June 18, 2026
Gene: Dmel\dachs
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General Information
Symbol
Dmel\dachs
Species
D. melanogaster
Name
dachs
Annotation Symbol
CG42840
Feature Type
protein_coding_gene
FlyBase ID
FBgn0262029
Gene Model Status
Current
Stock Availability
19 publicly available
Gene Summary
dachs (dachs) encodes a myosin family protein that participates in Dachsous-Fat signaling, which polarizes its localization. It influences planar cell polarity, partly through interaction with the product of pk, and growth, through interaction with the product of wts. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

d, Myo29D

Key Links
Genomic Location
Cytogenetic map
29D1-29D1
Sequence location
Recombination map
2-33
RefSeq locus
NT_033779 REGION:8466817..8488671
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (20 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
enables actin filament binding
inferred from direct assay
(Cao et al., 2014)
enables molecular adaptor activity
inferred from direct assay
(Cao et al., 2014)
enables protein binding
inferred from physical interaction with UniProtKB:Q9VUV7
(Misra and Irvine, 2019)
inferred from physical interaction with UniProtKB:A1ZAY1
(Zhang et al., 2016)
inferred from physical interaction with FLYBASE:Zyx; FB:FBgn0011642
(Cao et al., 2014)
NOT enables ATP binding
inferred from direct assay
(Cao et al., 2014)
NOT enables ATP hydrolysis activity
inferred from direct assay
(Cao et al., 2014)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables actin filament binding
inferred from biological aspect of ancestor with PANTHER:PTN000320364
(GO Reference Genome Project, 2011-)
enables ATP binding
inferred from electronic annotation with InterPro:IPR001609
(InterPro Project Members, 2004-)
enables cytoskeletal motor activity
inferred from electronic annotation with InterPro:IPR001609
(InterPro Project Members, 2004-)
NOT enables cytoskeletal motor activity
traceable author statement
(Cao et al., 2014)
Biological Process (10 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
involved_in establishment of ommatidial planar polarity
inferred from mutant phenotype
(Mao et al., 2006)
involved_in establishment of planar polarity
inferred from mutant phenotype
(Misra and Irvine, 2016, Bosveld et al., 2012)
involved_in imaginal disc-derived wing vein morphogenesis
inferred from mutant phenotype
(Mao et al., 2006)
involved_in leg disc development
inferred from mutant phenotype
(Mao et al., 2006)
involved_in negative regulation of hippo signaling
inferred from genetic interaction with FLYBASE:hpo; FB:FBgn0261456
(Zhang et al., 2016)
inferred from mutant phenotype
(Misra and Irvine, 2016)
involved_in positive regulation of growth
inferred from mutant phenotype
(Mao et al., 2006)
involved_in positive regulation of imaginal disc growth
inferred from mutant phenotype
(Rauskolb et al., 2011)
involved_in protein localization involved in establishment of planar polarity
inferred from direct assay
(Misra and Irvine, 2016)
involved_in wing disc development
inferred from mutant phenotype
(Mao et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in endocytosis
inferred from biological aspect of ancestor with PANTHER:PTN008546178
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in apicolateral plasma membrane
inferred from direct assay
(Misra and Irvine, 2016)
located_in cytosol
inferred from direct assay
(Mao et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in actin cytoskeleton
inferred from biological aspect of ancestor with PANTHER:PTN000320364
(GO Reference Genome Project, 2011-)
part_of myosin complex
inferred from electronic annotation with InterPro:IPR001609
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
dachs (dachs) encodes a myosin family protein that participates in Dachsous-Fat signaling, which polarizes its localization. It influences planar cell polarity, partly through interaction with the product of pk, and growth, through interaction with the product of wts. [Date last reviewed: 2019-03-07]
Pathway (FlyBase)
NEGATIVE REGULATORS OF HIPPO SIGNALING PATHWAY -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Negative regulators of the pathway promote the nuclear accumulation of yki, enhancing yki-mediated transcriptional regulation and the expression of genes that positively regulate tissue growth (Adapted from FBrf0224870).
Gene Group (FlyBase)
NON-MOTOR MYOSINS -
Non-motor myosins include class XX and XVIIIa myosins, which belong to the myosin superfamily but lack ATP-binding/ATPase activity and do not function as molecular motors. They are able to bind actin and are though to act as scaffold or actin tethering proteins. (Adapted from FBrf0213876 and FBrf0223842.)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
d: dachs
Similar to fj. Tarsi four jointed instead of five jointed owing to failure of joint formation between second and third tarsal segments (Tokunaga and Gerhart, 1976, Genetics 83: s76); joint remnants sometimes persist beneath the cuticle (Held, Duarte, and Derakhshanian, 1986, Wilhelm Roux's Arch. Dev. Biol. 195: 145-57). Legs short and held close to body. Femur, tibia, and tarsae foreshortened [Tokunaga and Gerhart; Mikuta and Mglinetz, 1979, Genetika (Moscow) 15: 624-32]. Probability of failure of joint formation proportional to degree of foreshortening of second tarsal segment (Tokunaga and Gerhart). Joint failure phenotype can extend into d/+ tissue adjacent to d/d clones (Tokunaga and Gerhart). Number of longitudinal rows of bristles in second basitarsus unaffected, but number of bristles per row reduced (Held, 1979, Wilhelm Roux's Arch. Dev. Biol. 187: 105-27). Leg effects enhanced by ssa and ssaB (Villee, 1945, Genetics 30: 26-27). Wings smaller than wild type, narrowed, with L2 and L3 joined near anterior crossvein; distance between crossveins smaller and crossveins sometimes absent. Angle between L2 and L5 greater than normal. Eyes small and rough. Posterior scutellar bristles erect. Viability erratic. Frequently sterile. Enhances transforming effects of AntpNs (Mikuta and Mglinetz, 1979) and pb; labial legs in d; pb flies show failure of joint formation [Kaurov, 1978, Genetika (Moscow) 14: 306-12]. RK2.
Summary (Interactive Fly)

unconventional myosin motor domain protein - acts as an F-Actin-binding scaffolding protein - downstream component of a Fat signaling pathway that influences growth, cell affinity and developmental gene expression

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\dachs for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry M9MRE4)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.40

Gene model reviewed during 5.45

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.52

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
dachs-RD
FBtr0303923
NM_001201800
5120
1244
dachs-RE
FBtr0303924
NM_001201801
5093
1426
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
dachs-PD
FBpp0292924
135.4
1244
9.75
B5RJR1
NP_001188729
ADV36979
dachs-PE
FBpp0292925
155.8
1426
9.28
M9MRE4
NP_001188730
ADV36980
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dachs using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.26

Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in apicolateral plasma membrane
inferred from direct assay
(Misra and Irvine, 2016)
located_in cytosol
inferred from direct assay
(Mao et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\dachs in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 28 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of dachs
Transgenic constructs containing regulatory region of dachs
Aberrations (Deficiencies and Duplications) ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
cell lethal | somatic clone
lethal
lethal | recessive
lethal - all die before end of P-stage
partially lethal - majority die, with Scer\GAL4pnr-MD237
partially lethal - majority live
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
fertile
semi-fertile
Other Phenotypes
Allele
abnormal cell polarity
abnormal planar polarity
abnormal planar polarity, with Scer\GAL4unspecified
abnormal planar polarity (with Df(2L)ED623)
abnormal planar polarity | adult stage (with dachs1)
abnormal planar polarity | adult stage (with dachsGC13)
abnormal size
abnormal size, with Scer\GAL4Bx-MS1096
abnormal size, with Scer\GAL4nub-AC-62
abnormal size | adult stage, with Scer\GAL4en-e16E
abnormal size | adult stage, with Scer\GAL4nub.PU
decreased cell number
decreased size | larval stage
hyperplasia | adult stage, with Scer\GAL4hh.PU
hyperplasia | adult stage, with Scer\GAL4Tub.PU
hypoplasia | adult stage, with Scer\GAL4Tub.PU
some die during pharate adult stage
some die during pupal stage, with Scer\GAL4pnr-MD237
visible
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4Tub.PU
visible (with dachs210)
visible (with dachsGC13)
visible (with Df(2L)ED623)
visible (with Df(2L)N22-5)
visible | adult stage, with Scer\GAL4en-e16E
visible | adult stage, with Scer\GAL4hh.PU
visible | adult stage, with Scer\GAL4Tub.PU
visible | adult stage | somatic clone
Phenotype manifest in
Allele
abdominal tergite marginal bristle (with dachs210)
abdominal tergite marginal bristle (with dachsGC13)
adult abdomen (with Df(2L)ED623)
anterior crossvein (with dachs1)
anterior crossvein (with dachs210)
anterior crossvein (with Df(2L)N22-5)
crossvein
crossvein, with Scer\GAL4Tub.PU
crossvein (with dachs1)
crossvein (with dachsGC13)
crossvein | ectopic (with dachs1)
crossvein | ectopic (with dachs210)
crossvein | ectopic (with Df(2L)N22-5)
crossvein | somatic clone
eye
eye | adult stage | somatic clone
eye disc | third instar larval stage (with dachs1)
eye disc | third instar larval stage (with dachsGC13)
femur
leg
leg, with Scer\GAL4Tub.PU
leg (with dachs210)
leg (with dachsGC13)
leg (with Df(2L)ED623)
leg | somatic clone
leg disc
leg sensillum
mesonotum, with Scer\GAL4pnr-MD237
mesothoracic tarsal bristle longitudinal row
metathoracic tarsal bristle longitudinal row
ommatidium
ommatidium | somatic clone
posterior scutellar bristle
prothoracic tarsal bristle longitudinal row
scutellum, with Scer\GAL4unspecified
tarsal segment
tarsal segment | somatic clone
tibia
trichogen cell, with Scer\GAL4pnr-MD237
wing
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4nub.PU
wing, with Scer\GAL4nub-AC-62
wing, with Scer\GAL4Tub.PU
wing (with Df(2L)N22-5)
wing | posterior, with Scer\GAL4en-e16E
wing | proximal (with dachs1)
wing | proximal (with dachsGC13)
wing blade, with Scer\GAL4Tub.PU
wing disc
wing disc | conditional
wing disc | third instar larval stage (with dachs1)
wing disc | third instar larval stage (with dachsGC13)
wing hair
wing hair (with dachs1)
wing hair (with dachsGC13)
wing hair (with Df(2L)ED623)
wing posterior compartment, with Scer\GAL4hh.PU
wing vein
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (29)
Hsap\MYO5A
3 of 14
Yes
No
Hsap\MYO5B
3 of 14
Yes
No
Hsap\MYO5C
3 of 14
Yes
No
Hsap\MYO19
3 of 14
Yes
No
Hsap\MYO1G
2 of 14
No
No
Hsap\ASPM
1 of 14
No
No
Hsap\IQCB1
1 of 14
No
Yes
Hsap\MYH9
1 of 14
No
No
2  
Hsap\MYH10
1 of 14
No
No
Hsap\MYO1A
1 of 14
No
No
Hsap\MYO1B
1 of 14
No
No
Hsap\MYO1C
1 of 14
No
No
Hsap\MYO1D
1 of 14
No
No
1  
Hsap\MYO1E
1 of 14
No
No
Hsap\MYO1F
1 of 14
No
No
Hsap\MYO1H
1 of 14
No
No
Hsap\MYO3A
1 of 14
No
No
Hsap\MYO3B
1 of 14
No
No
Hsap\MYO6
1 of 14
No
No
Hsap\MYO7A
1 of 14
No
No
Hsap\MYO7B
1 of 14
No
No
Hsap\MYO9A
1 of 14
No
No
Hsap\MYO9B
1 of 14
No
No
Hsap\MYO10
1 of 14
No
No
Hsap\MYO15A
1 of 14
No
No
Hsap\MYO15B
1 of 14
No
No
Hsap\MYO16
1 of 14
No
No
Hsap\RADIL
1 of 14
No
Yes
Hsap\RASIP1
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (21)
Rnor\Myo5b
3 of 14
Yes
No
Rnor\Myo5a
2 of 14
No
No
Rnor\Myo5c
2 of 14
No
No
Rnor\Myo19
2 of 14
No
No
Rnor\Aspm
1 of 14
No
No
Rnor\Iqcb1
1 of 14
No
Yes
Rnor\Myh10
1 of 14
No
No
Rnor\Myo1a
1 of 14
No
No
Rnor\Myo1b
1 of 14
No
No
Rnor\Myo1e
1 of 14
No
No
Rnor\Myo1f
1 of 14
No
No
Rnor\Myo3b
1 of 14
No
No
Rnor\Myo6
1 of 14
No
No
Rnor\Myo7a
1 of 14
No
No
Rnor\Myo7b
1 of 14
No
No
Rnor\Myo9b
1 of 14
No
No
Rnor\Myo10
1 of 14
No
No
Rnor\Myo15a
1 of 14
No
No
Rnor\Myo16
1 of 14
No
No
Rnor\Radil
1 of 14
No
Yes
Rnor\Rasip1
1 of 14
No
Yes
Mus musculus (laboratory mouse) (22)
Mmus\Myo5a
3 of 14
Yes
No
Mmus\Myo5b
3 of 14
Yes
No
Mmus\Myo5c
3 of 14
Yes
No
Mmus\Myo19
3 of 14
Yes
No
Mmus\Aspm
1 of 14
No
No
Mmus\Iqcb1
1 of 14
No
Yes
Mmus\Myh10
1 of 14
No
No
Mmus\Myo1a
1 of 14
No
No
Mmus\Myo1b
1 of 14
No
No
Mmus\Myo1c
1 of 14
No
No
Mmus\Myo1e
1 of 14
No
No
Mmus\Myo1f
1 of 14
No
No
Mmus\Myo1g
1 of 14
No
No
Mmus\Myo3b
1 of 14
No
No
Mmus\Myo7a
1 of 14
No
No
Mmus\Myo7b
1 of 14
No
No
Mmus\Myo9b
1 of 14
No
No
Mmus\Myo10
1 of 14
No
No
Mmus\Myo15
1 of 14
No
No
Mmus\Myo16
1 of 14
No
No
Mmus\Radil
1 of 14
No
Yes
Mmus\Rasip1
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (10)
Xtro\myo5a
2 of 13
Yes
No
Xtro\myo5c
2 of 13
Yes
No
Xtro\myo19
2 of 13
Yes
No
Xtro\myo1e.1
1 of 13
No
No
Xtro\myo1f
1 of 13
No
No
Xtro\myo5b
1 of 13
No
No
Xtro\myo6
1 of 13
No
No
Xtro\myo10.2
1 of 13
No
No
Xtro\nlgn3
1 of 13
No
No
Xtro\rpl11
1 of 13
No
No
Danio rerio (Zebrafish) (25)
Drer\myo5ab
3 of 14
Yes
No
Drer\myo5b
3 of 14
Yes
No
Drer\myo5aa
2 of 14
No
No
Drer\myo5c
2 of 14
No
No
Drer\LOC556989
1 of 14
No
No
Drer\LOC100332329
1 of 14
No
Yes
Drer\LOC108190403
1 of 14
No
No
Drer\myo1b
1 of 14
No
No
Drer\myo1ca
1 of 14
No
No
Drer\myo1cb
1 of 14
No
No
Drer\myo1eb
1 of 14
No
No
Drer\myo1f
1 of 14
No
No
Drer\myo1ha
1 of 14
No
No
Drer\myo3a
1 of 14
No
No
Drer\myo3b
1 of 14
No
No
Drer\myo6a
1 of 14
No
No
Drer\myo7aa
1 of 14
No
No
Drer\myo9aa
1 of 14
No
No
Drer\myo9b
1 of 14
No
No
Drer\myo10
1 of 14
No
No
Drer\myo10l1
1 of 14
No
No
Drer\myo15aa
1 of 14
No
No
Drer\myo19
1 of 14
No
Yes
Drer\rasip1
1 of 14
No
Yes
Drer\si:dkey-110c1.10
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (10)
Cele\hum-2
2 of 14
Yes
No
Cele\hum-4
2 of 14
Yes
No
Cele\hum-10
2 of 14
Yes
Yes
Cele\hum-1
1 of 14
No
No
Cele\hum-5
1 of 14
No
No
Cele\hum-6
1 of 14
No
No
Cele\hum-7
1 of 14
No
Yes
Cele\hum-8
1 of 14
No
No
Cele\myo-3
1 of 14
No
No
Cele\spe-15
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (5)
Agam\AgaP_AGAP009933
11 of 12
Yes
Yes
Agam\AgaP_AGAP006479
3 of 12
No
No
Agam\AgaP_AGAP004000
1 of 12
No
No
Agam\AgaP_AGAP005213
1 of 12
No
No
Agam\AgaP_AGAP009730
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (20)
Atha\ATM1
3 of 13
Yes
No
Atha\ATM2
3 of 13
Yes
No
Atha\MYA1
3 of 13
Yes
No
Atha\MYA2
3 of 13
Yes
No
Atha\VIIIA
3 of 13
Yes
No
Atha\VIIIB
3 of 13
Yes
No
Atha\XIA
3 of 13
Yes
No
Atha\XIB
3 of 13
Yes
No
Atha\XIC
3 of 13
Yes
No
Atha\XID
3 of 13
Yes
No
Atha\XIE
3 of 13
Yes
No
Atha\XIF
3 of 13
Yes
No
Atha\XIG
3 of 13
Yes
No
Atha\XIH
3 of 13
Yes
No
Atha\XI-I
3 of 13
Yes
No
Atha\XIJ
3 of 13
Yes
No
Atha\XIK
3 of 13
Yes
No
Atha\AT1G42680
1 of 13
No
Yes
Atha\AT5G20450
1 of 13
No
No
Atha\HDK
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\MYO2
2 of 13
Yes
No
Scer\MYO4
2 of 13
Yes
No
Scer\MYO1
1 of 13
No
No
Scer\MYO3
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\myo51
2 of 12
Yes
No
Spom\myo52
2 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:dachs. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (15)
didum
5 of 13
ck
3 of 13
jar
3 of 13
Myo10A
3 of 13
Myo28B1
3 of 13
Myo31DF
3 of 13
Myo61F
3 of 13
Myo81F
2 of 13
Myo95E
2 of 13
CG31638
1 of 13
CG43796
1 of 13
Mhcl
1 of 13
Mhc
1 of 13
Prm
1 of 13
zip
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Human Ortholog
    Disease
    Evidence
    References
    MYO5B; myosin VB
    model of  microvillus inclusion disease
    IEA
    (FlyBase, 2019-)
    MYO5A; myosin VA
    model of  Griscelli syndrome type 1
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    dachsGC13
    ameliorates  dentatorubral-pallidoluysian atrophy
    modeled by Gug75QN.UAS
    (Napoletano et al., 2011)
    ameliorates  neurodegenerative disease
    modeled by ft8
    (Napoletano et al., 2011)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    MYO5A; myosin VA
    3 of 14
    160777
    MYO5B; myosin VB
    3 of 14
    606540
    MYO5C; myosin VC
    3 of 14
    610022
        MYO19; myosin XIX
        3 of 14
        617379
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            dachs - CG8507
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            dachs - Cam
            anti tag coimmunoprecipitation, peptide massfingerprinting, molecular weight estimation by staining
            (Cao et al., 2014, Kwon et al., 2013)
            dachs - Cortactin
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            dachs - Dbct
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            dachs - Dlish
            anti tag coimmunoprecipitation, anti tag western blot, pull down, two hybrid, peptide massfingerprinting
            (Wang et al., 2019, Misra and Irvine, 2016, Zhang et al., 2016, Kwon et al., 2013)
            dachs - ERp60
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            dachs - Fmr1
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            dachs - Pabp2
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            dachs - RPA1
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            dachs - Rcc1
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            dachs - Ref1
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            dachs - Rm62
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            dachs - Swip-1
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            dachs - Ubi-p5E
            anti tag coimmunoprecipitation, anti tag western blot, western blot
            (Bosch et al., 2014)
            dachs - Ubi-p63E
            anti tag coimmunoprecipitation, western blot
            (Bosch et al., 2014)
            dachs - Vap33
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            dachs - Ythdc1
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            dachs - Zyx
            anti tag coimmunoprecipitation, anti tag western blot
            (Cao et al., 2014, Rauskolb et al., 2011)
            dachs - app
            anti tag coimmunoprecipitation, western blot
            (Matakatsu et al., 2017)
            dachs - ds
            anti tag coimmunoprecipitation, anti tag western blot
            (Tripathi and Irvine, 2024, Bosveld et al., 2012)
            dachs - elgi
            anti tag coimmunoprecipitation, anti tag western blot
            (Misra and Irvine, 2019)
            dachs - jub
            anti tag coimmunoprecipitation, anti tag western blot
            (Rauskolb et al., 2011)
            dachs - kst
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            dachs - pk
            coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot
            (Ambegaonkar and Irvine, 2015, Ayukawa et al., 2014)
            dachs - pod1
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            dachs - ref(2)P
            anti tag coimmunoprecipitation, peptide massfingerprinting, western blot
            (Nagai et al., 2021, Kwon et al., 2013)
            dachs - shrb
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            dachs - ssx
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            dachs - sti
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            dachs - tum
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            dachs - vig2
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            dachs - wts
            anti tag coimmunoprecipitation, anti tag western blot
            (Rauskolb et al., 2011, Cho et al., 2006)
            dachs - α-Spec
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            Summary of Genetic Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            dachs
            suppressible
            Dlish
            (Zhang et al., 2016)
            dachs
            enhanceable
            Dlish
            (Misra and Irvine, 2016)
            dachs
            enhanceable
            Fbxl7
            (Rodrigues-Campos and Thompson, 2014)
            dachs
            suppressible
            Tao
            (Poon et al., 2011)
            dachs|ft
            enhanceable
            yki
            (Brittle et al., 2012)
            dachs
            suppressible
            Zyx
            (Rauskolb et al., 2011)
            dachs
            enhanceable
            Zyx
            (Gaspar et al., 2015, Rauskolb et al., 2011)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Antp
            enhanceable
            dachs
            (Mikuta and Mglinetz, 1979)
            app
            suppressible
            dachs
            (Matakatsu and Blair, 2008)
            cg
            enhanceable
            dachs
            (Waddington, 1953)
            dco
            suppressible
            dachs
            (Cho et al., 2006)
            Dlish
            enhanceable
            dachs
            (Misra and Irvine, 2016)
            ds
            suppressible
            dachs
            (Brittle et al., 2012)
            Fbxl7
            enhanceable
            dachs
            (Rodrigues-Campos and Thompson, 2014)
            fj
            enhanceable
            dachs
            (Buckles et al., 2001)
            ft
            suppressible
            dachs
            (Brittle et al., 2012, Napoletano et al., 2011, Mao et al., 2006)
            ft|ds
            suppressible
            dachs
            (Matakatsu and Fehon, 2024)
            Gug
            suppressible
            dachs
            (Napoletano et al., 2011)
            pb
            enhanceable
            dachs
            Zyx
            enhanceable
            dachs
            (Rauskolb et al., 2011)
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            External Data
            Linkouts
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map
            2-33
            Cytogenetic map
            29D1-29D1
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            29D1-29D1
            Limits computationally determined from genome sequence between P{lacW}l(2)k03706k03706&P{lacW}Acerk07704 and P{PZ}lmg03424
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            29D1-29D1
            (Tzolovsky, 2001.12.3)
            Experimentally Determined Recombination Data
            Location

            2-33

            (FlyBase, 2016)

            2-27.9

            (Comeron et al., 2012)

            2-31.0

            (Goldschmidt, 1944)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (19)
            Genomic Clones (21)
            cDNA Clones (30)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 
                Other Comments

                The motor domain of d has neither ATPase activity nor the ability to bind ATP in vitro. The motor domain of d binds to F-actin in an ATP-independent manner and enhances the interaction between actin filaments and Zyx in vitro. This suggests that d functions as a scaffold protein, but not as a molecular motor.

                (Cao et al., 2014)

                d acts downstream of ft.

                (Mao et al., 2006)

                dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                (Kiger et al., 2003)

                New annotation (CG31610) in release 3 of the genome annotation. CG31610 merged into CG10595 in release 3 of the genome annotation, October 2002.

                (FlyBase Genome Annotators, 2002-2003)
                Relationship to Other Genes
                Source for database merge of

                Source for merge of: d l(2)c00146

                (FlyBase, 1996-)

                Source for merge of: d anon- EST:Liang-1.78

                (Tzolovsky et al., 2002)

                Source for merge of: d CG10595

                (FlyBase, 1996-)

                Source for merge of: d CG13087

                (FlyBase Genome Annotators, 2010)
                Additional comments

                unsRNA:d-a is encoded in an intron of d.

                (Graveley et al., 2011)

                Annotations CG10595 and CG13087 merged as CG42840 in release 5.30 of the genome annotation.

                (FlyBase Genome Annotators, 2010)

                Source for merge of d CG10595 was sequence comparison ( date:010908 ).

                (FlyBase, 1996-)
                Nomenclature History
                Source for database identify of

                Source for identity of: dachs d

                (FlyBase, 2009-)
                Nomenclature comments

                Changed gene symbol 'd' to 'dachs' (i.e. same as its full name) to eliminate the case-insensitive duplication with the 'D' (Dichaete) gene symbol.

                (FlyBase, 2009-)
                Etymology
                Synonyms and Secondary IDs (22)
                Reported As
                Symbol Synonym
                29C3-D1
                (Oliver et al., 1999)
                29CD
                (Berg et al., 2001)
                AAF52683
                (Yamashita et al., 2000)
                CG10595
                (Petzoldt et al., 2012, Keleman et al., 2009.8.5, Perkins et al., 2009, Mao et al., 2006, Tzolovsky et al., 2002)
                CG13087
                (Ashwal-Fluss et al., 2014, Keleman et al., 2009.8.5)
                CG31610
                CG42840
                (National Institute of Genetics Fly Stocks, 2022-, Hosono et al., 2015, FlyBase Genome Annotators, 2010, Ni et al., 2010.12.1)
                D
                (Fulford and McNeill, 2020, Fulford et al., 2018, Richardson and Portela, 2017, Misra and Irvine, 2016, Wittkorn et al., 2015, Bossuyt et al., 2014, Grifoni et al., 2013, Harvey and Hariharan, 2012, Halder and Johnson, 2011, Milton et al., 2010, Hariharan, 2006)
                Dachs
                (Athilingam et al., 2021, Boumard and Bardin, 2021, Dye et al., 2021, Strutt and Strutt, 2021, Thompson, 2021, van Soldt and Cardoso, 2020, Misra and Irvine, 2019, Fallahi et al., 2016, Misra and Irvine, 2016, Irvine and Harvey, 2015, Matsui and Lai, 2013, Liu et al., 2012)
                Dh
                (Gou et al., 2018)
                DmMyo20
                (Cao et al., 2014)
                Ds
                (Pan et al., 2013)
                Myo29D
                (Tzolovsky et al., 2002, Tzolovsky, 2001.12.3)
                Myo3A
                (Kollmar, 2015.9.15)
                anon-EST:Liang-1.78
                clone 1.78
                (Liang and Biggin, 1998)
                d
                (National Institute of Genetics Fly Stocks, 2022-, Yan et al., 2022, Zecca and Struhl, 2021, Li and Hidalgo, 2020, Mahmud et al., 2020, Wang et al., 2019, Mangione and Martín-Blanco, 2018, Matakatsu et al., 2017, Misra and Irvine, 2016, Saavedra et al., 2016, Gaspar et al., 2015, Kwon et al., 2015, Okumura et al., 2015, Vrabioiu and Struhl, 2015, Toshima et al., 2014, Kwon et al., 2013, Kwon et al., 2013, Marcinkevicius and Zallen, 2013, Sharma and McNeill, 2013, Brittle et al., 2012, Singh and Mlodzik, 2012, Bao et al., 2011, Graveley et al., 2011, Jukam and Desplan, 2011, Kawamori et al., 2011, Li et al., 2011, Liu et al., 2011, Napoletano et al., 2011, Reddy et al., 2010, Zecca and Struhl, 2010, Inomata et al., 2008, Matakatsu and Blair, 2008, Yang et al., 2008, Cho et al., 2006, Christensen and Cook, 2006.8.30)
                dachs
                (Fischer et al., 2024, Luo et al., 2024, Matakatsu and Fehon, 2024, Arata et al., 2017, Montes and Morata, 2017, Su, 2015, Degoutin et al., 2013, Marcinkevicius and Zallen, 2013, Grusche et al., 2011, Feng and Irvine, 2007)
                l(2)c00146
                Name Synonyms
                Dachs
                (Fulford et al., 2023, Muñoz-Nava et al., 2021, Gou et al., 2020, Mohammadi et al., 2020, Garrido-Jimenez et al., 2019, Suisse and Treisman, 2019, Gou et al., 2018, Richardson and Portela, 2017, Misra and Irvine, 2016, Wittkorn et al., 2015, Bosch et al., 2014, Bossuyt et al., 2014, Degoutin et al., 2013, Kwon et al., 2013, Lawrence and Casal, 2013, Mao et al., 2013, Pan et al., 2013, Sharma and McNeill, 2013, Yu and Guan, 2013, Ambegaonkar et al., 2012, Ambegaonkar et al., 2012, Fausti et al., 2012, Liu et al., 2012, Singh and Mlodzik, 2012, Bao et al., 2011, Halder and Johnson, 2011, Zhao et al., 2011, Feng and Irvine, 2009)
                dachs
                (Tokamov et al., 2021, Misra and Irvine, 2019, Zhang et al., 2016, Kwon et al., 2015, Okumura et al., 2015, Cao et al., 2014, Merkel et al., 2014, Rodrigues-Campos and Thompson, 2014, Degoutin et al., 2013, Bosveld et al., 2012, Bosveld et al., 2012, Brittle et al., 2012, Petzoldt et al., 2012, Yue et al., 2012, Goodrich and Strutt, 2011, Jukam and Desplan, 2011, Mao et al., 2011, Poon et al., 2011, Rauskolb et al., 2011, Milton et al., 2010, Reddy et al., 2010, Robinson et al., 2010, Zecca and Struhl, 2010, Matakatsu and Blair, 2008, Rogulja et al., 2008, Willecke et al., 2008, Feng et al., 2007, Cho et al., 2006, Hariharan, 2006, Mao et al., 2006)
                lethal (2) c00146
                myosin 29D
                (Millo et al., 2004)
                unconventional myosin 29D
                (Tzolovsky, 2001.12.3)
                Secondary FlyBase IDs
                • FBgn0032045
                • FBgn0086896
                • FBgn0000410
                • FBgn0025975
                • FBgn0032046
                • FBgn0051610
                • FBgn0069196
                Datasets (1)
                Study focus (1)
                Experimental Role
                Project
                Project Type
                Title
                • bait_protein
                Hippo_Pathway_interaction_map
                Interaction map generated by purification of Hippo pathway factors, with identification of copurifying proteins by mass spectrometry.
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 59 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                References (197)