FlyBase Gene Report: Dmel\d

General Information

Symbol

Dmel\d

Species

D. melanogaster

Name

dachs

Annotation Symbol

CG42840

Feature Type

protein_coding_gene

FlyBase ID

FBgn0262029

Gene Model Status

Stock Availability

19 publicly available

Gene Snapshot

dachs (d) encodes a myosin family protein that participates in Dachsous-Fat signaling, which polarizes its localization. It influences planar cell polarity, partly through interaction with the product of pk, and growth, through interaction with the product of wts. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Pathway
Gene Group
Red Book
Interactive Fly

Also Known As

Myo29D

Key Links

Genomic Location

Cytogenetic map

Sequence location

2L:8,466,817..8,488,671 [+]

Recombination map

2-33

RefSeq locus

NT_033779 REGION:8466817..8488671

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (24 terms)

Molecular Function (7 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

enables actin filament binding

inferred from direct assay

(Cao et al., 2014)

NOT enables ATP binding

inferred from direct assay

(Cao et al., 2014)

NOT enables ATPase activity

inferred from direct assay

(Cao et al., 2014)

enables protein binding

inferred from physical interaction with UniProtKB:Q9VUV7

(assigned by UniProt )

(Misra and Irvine, 2019)

inferred from physical interaction with UniProtKB:A1ZAY1

(assigned by UniProt )

(Zhang et al., 2016)

inferred from physical interaction with FLYBASE:Zyx; FB:FBgn0011642

(Cao et al., 2014)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables actin filament binding

inferred from biological aspect of ancestor with PANTHER:PTN000320364

(assigned by GO_Central )

(Gaudet et al., 2011)

NOT enables microfilament motor activity

inferred by curator from GO:0005524,GO:0016887

(Cao et al., 2014)

enables molecular adaptor activity

inferred by curator from GO:0005515,GO:0051015

(Cao et al., 2014)

enables motor activity

inferred from electronic annotation with InterPro:IPR001609

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (11 terms)

Terms Based on Experimental Evidence (9 terms)

CV Term

Evidence

References

involved_in establishment of ommatidial planar polarity

inferred from mutant phenotype

(Mao et al., 2006)

involved_in establishment of planar polarity

inferred from mutant phenotype

(Misra and Irvine, 2016, Bosveld et al., 2012)

involved_in imaginal disc-derived wing vein morphogenesis

inferred from mutant phenotype

(Mao et al., 2006)

involved_in leg disc development

inferred from mutant phenotype

(Mao et al., 2006)

involved_in negative regulation of hippo signaling

inferred from genetic interaction with FLYBASE:hpo; FB:FBgn0261456

(Zhang et al., 2016)

inferred from mutant phenotype

(Misra and Irvine, 2016)

involved_in positive regulation of growth

inferred from mutant phenotype

(Mao et al., 2006)

involved_in positive regulation of imaginal disc growth

inferred from mutant phenotype

(Rauskolb et al., 2011)

involved_in protein localization involved in establishment of planar polarity

inferred from direct assay

(Misra and Irvine, 2016)

involved_in wing disc development

inferred from mutant phenotype

(Mao et al., 2006)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in actin filament organization

inferred from biological aspect of ancestor with PANTHER:PTN000320364

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in vesicle transport along actin filament

inferred from biological aspect of ancestor with PANTHER:PTN000320364

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in apicolateral plasma membrane

inferred from direct assay

(Misra and Irvine, 2016)

located_in cytosol

inferred from direct assay

(Mao et al., 2006)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

located_in actin cytoskeleton

inferred from biological aspect of ancestor with PANTHER:PTN000320364

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000320364

(assigned by GO_Central )

(Gaudet et al., 2011)

part_of myosin complex

inferred from electronic annotation with InterPro:IPR001609

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

located_in vesicle

inferred from biological aspect of ancestor with PANTHER:PTN000320364

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

NON-MOTOR MYOSINS

Pathway (FlyBase)

Negative Regulators of Hippo Signaling Pathway

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Pathway (FlyBase)

Negative Regulators of Hippo Signaling Pathway -: The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Negative regulators of the pathway promote the nuclear accumulation of yki, enhancing yki-mediated transcriptional regulation and the expression of genes that positively regulate tissue growth (Adapted from FBrf0224870).

Gene Group (FlyBase)

NON-MOTOR MYOSINS -: Non-motor myosins include class XX and XVIIIa myosins, which belong to the myosin superfamily but lack ATP-binding/ATPase activity and do not function as molecular motors. They are able to bind actin and are though to act as scaffold or actin tethering proteins. (Adapted from FBrf0213876 and FBrf0223842.)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

d: dachs

Similar to fj. Tarsi four jointed instead of five jointed owing to failure of joint formation between second and third tarsal segments (Tokunaga and Gerhart, 1976, Genetics 83: s76); joint remnants sometimes persist beneath the cuticle (Held, Duarte, and Derakhshanian, 1986, Wilhelm Roux's Arch. Dev. Biol. 195: 145-57). Legs short and held close to body. Femur, tibia, and tarsae foreshortened [Tokunaga and Gerhart; Mikuta and Mglinetz, 1979, Genetika (Moscow) 15: 624-32]. Probability of failure of joint formation proportional to degree of foreshortening of second tarsal segment (Tokunaga and Gerhart). Joint failure phenotype can extend into d/+ tissue adjacent to d/d clones (Tokunaga and Gerhart). Number of longitudinal rows of bristles in second basitarsus unaffected, but number of bristles per row reduced (Held, 1979, Wilhelm Roux's Arch. Dev. Biol. 187: 105-27). Leg effects enhanced by ssa and ssaB (Villee, 1945, Genetics 30: 26-27). Wings smaller than wild type, narrowed, with L2 and L3 joined near anterior crossvein; distance between crossveins smaller and crossveins sometimes absent. Angle between L2 and L5 greater than normal. Eyes small and rough. Posterior scutellar bristles erect. Viability erratic. Frequently sterile. Enhances transforming effects of AntpNs (Mikuta and Mglinetz, 1979) and pb; labial legs in d; pb flies show failure of joint formation [Kaurov, 1978, Genetika (Moscow) 14: 306-12]. RK2.

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

2

Number of Unique Polypeptides

2

Please see the JBrowse view of Dmel\d for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.40

Gene model reviewed during 5.45

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0303923

5120

1244

FBtr0303924

5093

1426

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0292924

135.4

1244

9.75

FBpp0292925

155.8

1426

9.28

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\d using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

d_1
d_2

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 7 -- 8

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

foregut primordium

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

dorsal epidermis primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic foregut

(Fisher et al., 2012)

embryonic head epidermis

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in apicolateral plasma membrane

inferred from direct assay

(Misra and Irvine, 2016)

located_in cytosol

inferred from direct assay

(Mao et al., 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\d in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\d

View exonic expression by tissue for Dmel\d

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0262029

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG42840

Images

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 24 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of d

Transgenic constructs containing regulatory region of d

Deletions and Duplications ( 6 )

Not disrupted in

(Mao et al., 2006)

(Mao et al., 2006)

Disrupted in

(Christensen and Cook, 2006.8.30)

(Ryder, 2004.4.26)

(Mao et al., 2006, Thibault et al., 2004)

(Mao et al., 2006)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

FlyBase_internaltransgene_features:cell lethal:cell lethal | somatic clone

d²¹⁰

d^GC13

lethal | recessive

d^c00146

lethal - all die before end of P-stage

d^GC13

partially lethal - majority die, with Scer\GAL4^pnr-MD237

d^GD7918

partially lethal - majority live

d¹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

d^GD4041

Sterility

Allele

d^c00148

d¹

Other Phenotypes

Allele

cell polarity defective

d^GC13

decreased cell number

d¹

hyperplasia | adult stage, with Scer\GAL4^hh.PU

hyperplasia | adult stage, with Scer\GAL4^Tub.PU

d^{UAS.Tag:V5,Tag:polyHis}

hypoplasia | adult stage, with Scer\GAL4^Tub.PU

d^{ΔN.UAS.Tag:V5}

planar polarity defective

d¹

planar polarity defective, with Scer\GAL4^unspecified

d^GD4041

planar polarity defective (with Df(2L)ED623)

d^GC13

d^GC13

size defective, with Scer\GAL4^Bx-MS1096

d^UAS.cMa

size defective, with Scer\GAL4^nub-AC-62

d^{UAS.Tag:V5,Tag:polyHis}

size defective | adult stage, with Scer\GAL4^en-e16E

d^{UAS.Tag:V5,Tag:polyHis}

size defective | adult stage, with Scer\GAL4^nub.PU

d^{UAS.Tag:V5,Tag:polyHis}

some die during pharate adult stage

d^GC13

some die during pupal stage, with Scer\GAL4^pnr-MD237

d^GD7918

visible, with Scer\GAL4^pnr-MD237

d^GD4041

visible, with Scer\GAL4^Tub.PU

d^{UAS.Tag:V5,Tag:polyHis}

visible (with d²¹⁰)

d^GC13

visible (with d^GC13)

d²¹⁰

visible (with Df(2L)ED623)

d^GC13

visible (with Df(2L)N22-5)

d^GC13

visible | adult stage, with Scer\GAL4^en-e16E

d^{UAS.Tag:V5,Tag:polyHis}

visible | adult stage, with Scer\GAL4^hh.PU

visible | adult stage, with Scer\GAL4^Tub.PU

visible | adult stage | somatic clone

d^GC13

Phenotype manifest in

Allele

abdominal tergite marginal bristle (with d²¹⁰)

d^GC13

abdominal tergite marginal bristle (with d^GC13)

d²¹⁰

adult abdomen (with Df(2L)ED623)

d^GC13

anterior crossvein (with d¹)

d²¹⁰

anterior crossvein (with d²¹⁰)

d¹

anterior crossvein (with Df(2L)N22-5)

d¹

crossvein, with Scer\GAL4^Tub.PU

d^{UAS.Tag:V5,Tag:polyHis}

crossvein (with d¹)

d^GC13

crossvein (with d^GC13)

d¹

crossvein | ectopic (with d¹)

d²¹⁰

crossvein | ectopic (with d²¹⁰)

d¹

crossvein | ectopic (with Df(2L)N22-5)

d¹

crossvein | somatic clone

d^GC13

d¹

eye | adult stage | somatic clone

d^GC13

eye disc | third instar larval stage (with d¹)

d^GC13

eye disc | third instar larval stage (with d^GC13)

d¹

d¹

leg, with Scer\GAL4^Tub.PU

d^{UAS.Tag:V5,Tag:polyHis}

leg (with d²¹⁰)

d^GC13

leg (with d^GC13)

d²¹⁰

leg (with Df(2L)ED623)

d^GC13

leg | somatic clone

d^GC13

d^GC13

mesothoracic tarsal bristle longitudinal row

d¹

mesothoracic tergum, with Scer\GAL4^pnr-MD237

d^GD4041

metathoracic tarsal bristle longitudinal row

d¹

d^GC13

ommatidium | somatic clone

d^GC13

posterior scutellar bristle

d¹

prothoracic tarsal bristle longitudinal row

d¹

scutellum, with Scer\GAL4^unspecified

d^GD4041

tarsal segment | somatic clone

d^GC13

d¹

trichogen cell, with Scer\GAL4^pnr-MD237

d^GD4041

ventral thoracic disc

wing, with Scer\GAL4^Bx-MS1096

d^UAS.cMa

wing, with Scer\GAL4^nub.PU

d^{UAS.Tag:V5,Tag:polyHis}

wing, with Scer\GAL4^nub-AC-62

d^{UAS.Tag:V5,Tag:polyHis}

wing, with Scer\GAL4^Tub.PU

d^{UAS.Tag:V5,Tag:polyHis}

wing (with Df(2L)N22-5)

d^GC13

wing | posterior, with Scer\GAL4^en-e16E

d^{UAS.Tag:V5,Tag:polyHis}

wing blade, with Scer\GAL4^Tub.PU

wing disc | conditional

d^GC13

wing disc | third instar larval stage (with d¹)

d^GC13

wing disc | third instar larval stage (with d^GC13)

d¹

wing hair (with Df(2L)ED623)

d^GC13

wing posterior compartment, with Scer\GAL4^hh.PU

d¹

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (10)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

2 of 15

Yes

No

2 of 15

Yes

No

2 of 15

Yes

No

2 of 15

Yes

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (11)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

2 of 15

Yes

No

2 of 15

Yes

No

2 of 15

Yes

No

2 of 15

Yes

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

Rattus norvegicus (Norway rat) (9)

2 of 13

Yes

No

2 of 13

Yes

No

2 of 13

Yes

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

Yes

Xenopus tropicalis (Western clawed frog) (7)

2 of 12

Yes

No

2 of 12

Yes

No

2 of 12

Yes

No

1 of 12

No

Yes

1 of 12

No

No

1 of 12

No

No

1 of 12

No

Yes

Danio rerio (Zebrafish) (9)

2 of 15

Yes

No

2 of 15

Yes

No

2 of 15

Yes

No

2 of 15

Yes

No

2 of 15

Yes

No

Drer\si:dkey-110c1.10

2 of 15

Yes

No

1 of 15

No

Yes

1 of 15

No

Yes

1 of 15

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (3)

2 of 15

Yes

No

1 of 15

No

No

1 of 15

No

Yes

Arabidopsis thaliana (thale-cress) (17)

2 of 9

Yes

No

2 of 9

Yes

No

2 of 9

Yes

No

2 of 9

Yes

No

2 of 9

Yes

No

2 of 9

Yes

No

1 of 9

No

No

1 of 9

No

No

1 of 9

No

No

1 of 9

No

No

1 of 9

No

No

1 of 9

No

No

1 of 9

No

No

1 of 9

No

No

1 of 9

No

No

1 of 9

No

No

1 of 9

No

No

Saccharomyces cerevisiae (Brewer's yeast) (2)

1 of 15

Yes

No

1 of 15

Yes

No

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900XN )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00000347

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500RH )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY000852

Mayetiola destructor

Hessian fly

Mdes\Mdes006863

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL012449

Anopheles darlingi

American malaria mosquito

Adar\ADAC004312

Anopheles gambiae

Malaria mosquito

Agam\AGAP009933

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ017570

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01BC )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA004656

Danaus plexippus

Monarch butterfly

Dple\DPOGS212363-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL005306

Apis florea

Little honeybee

Aflo\3249584068

Apis mellifera

Western honey bee

Apis mellifera

Western honey bee

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000067

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG000223

Dendroctonus ponderosae

Mountain pine beetle

Dendroctonus ponderosae

Mountain pine beetle

Dendroctonus ponderosae

Mountain pine beetle

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM205430

Rhodnius prolixus

Kissing bug

Rpro\RPRC009834

Cimex lectularius

Bed bug

Clec\CLEC012615

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI071965

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_15653

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00WI )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR001509

Ixodes scapularis

Black-legged tick

Isca\ISCW009513

Stegodyphus mimosarum

African social velvet spider

Smim\KFM58641.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM58637.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur26g00140

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_40739

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01EG )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-MyXII_1

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (15)

Gene Symbol

Score

Source

Alignment

4 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

ameliorates dentatorubral-pallidoluysian atrophy

modeled by Gug^75QN.UAS

(Napoletano et al., 2011)

ameliorates neurodegenerative disease

modeled by ft⁸

(Napoletano et al., 2011)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, molecular weight estimation by staining, peptide massfingerprinting

(Cao et al., 2014, Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, anti tag western blot, pull down, two hybrid, peptide massfingerprinting

(Wang et al., 2019, Misra and Irvine, 2016, Zhang et al., 2016, Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, western blot, anti tag western blot

(Bosch et al., 2014)

anti tag coimmunoprecipitation, western blot

(Bosch et al., 2014)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, anti tag western blot

(Cao et al., 2014, Rauskolb et al., 2011)

anti tag coimmunoprecipitation, western blot

(Matakatsu et al., 2017)

anti tag coimmunoprecipitation

(Bosveld et al., 2012)

anti tag coimmunoprecipitation, anti tag western blot

(Misra and Irvine, 2019)

anti tag coimmunoprecipitation, anti tag western blot

(Rauskolb et al., 2011)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, anti tag western blot, coimmunoprecipitation, western blot

(Ambegaonkar and Irvine, 2015, Ayukawa et al., 2014)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

anti tag coimmunoprecipitation, anti tag western blot

(Rauskolb et al., 2011, Cho et al., 2006)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kwon et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Misra and Irvine, 2016)

suppressible

(Zhang et al., 2016)

enhanceable

(Rodrigues-Campos and Thompson, 2014)

suppressible

(Poon et al., 2011)

enhanceable

(Gaspar et al., 2015, Rauskolb et al., 2011)

suppressible

(Rauskolb et al., 2011)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Mikuta and Mglinetz, 1979)

suppressible

(Matakatsu and Blair, 2008)

enhanceable

(Waddington, 1953)

suppressible

(Cho et al., 2006)

enhanceable

(Misra and Irvine, 2016)

enhanceable

(Rodrigues-Campos and Thompson, 2014)

enhanceable

(Buckles et al., 2001)

suppressible

(Napoletano et al., 2011, Mao et al., 2006)

suppressible

(Napoletano et al., 2011)

enhanceable

enhanceable

(Rauskolb et al., 2011)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0262029

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

34179

MIST (genetic) - An integrated Molecular Interaction Database

d

MIST (protein-protein) - An integrated Molecular Interaction Database

d

Pathways

Signaling Pathways (FlyBase)

Negative Regulators of Hippo Signaling Pathway -: The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Negative regulators of the pathway promote the nuclear accumulation of yki, enhancing yki-mediated transcriptional regulation and the expression of genes that positively regulate tissue growth (Adapted from FBrf0224870).

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Hippo signaling pathway - fly

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2L

Recombination map

2-33

Cytogenetic map

Sequence location

2L:8,466,817..8,488,671 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

29D1-29D1

Limits computationally determined from genome sequence between P{lacW}l(2)k03706^k03706&P{lacW}Acer^k07704 and P{PZ}lmg⁰³⁴²⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

29D1-29D1

(Tzolovsky, 2001.12.3)

Experimentally Determined Recombination Data

Location

2-33

(FlyBase, 2016)

2-27.9

(Comeron et al., 2012)

2-31.0

(Goldschmidt, 1944)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (19)

270

28291

w^*; P{UAS-d.V5}9-F

6388

d²¹⁰ pr¹/CyO

28814

w^*; P{UAS-d.V5}50-5/CyO

10022

w¹¹¹⁸; PBac{PB}d^c00148

27664

y¹ v¹; P{TRiP.JF02743}attP2

42381

y¹ w^*; Mi{MIC}d^MI06270

v102504

P{KK111834}VIE-260B

v102550

P{KK111964}VIE-260B

v12555

w¹¹¹⁸; P{GD4041}v12555

v32142

w¹¹¹⁸; P{GD7918}v32142

v12556

w¹¹¹⁸; P{GD4041}v12556/TM3

More stocks available...

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (31)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

RT07339

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0262029

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0262029

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34179

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: d l(2)c00146

(FlyBase, 1996-)

Source for merge of: d anon- EST:Liang-1.78

(Tzolovsky et al., 2002)

Source for merge of: d CG10595

(FlyBase, 1996-)

Source for merge of: d CG13087

(FlyBase Genome Annotators, 2010)

Additional comments

unsRNA:d-a is encoded in an intron of d.

(Graveley et al., 2011)

Annotations CG10595 and CG13087 merged as CG42840 in release 5.30 of the genome annotation.

(FlyBase Genome Annotators, 2010)

Source for merge of d CG10595 was sequence comparison ( date:010908 ).

(FlyBase, 1996-)

Other Comments

The motor domain of d has neither ATPase activity nor the ability to bind ATP in vitro. The motor domain of d binds to F-actin in an ATP-independent manner and enhances the interaction between actin filaments and Zyx in vitro. This suggests that d functions as a scaffold protein, but not as a molecular motor.

(Cao et al., 2014)

d acts downstream of ft.

(Mao et al., 2006)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

New annotation (CG31610) in release 3 of the genome annotation. CG31610 merged into CG10595 in release 3 of the genome annotation, October 2002.

(FlyBase Genome Annotators, 2002-2003)

Origin and Etymology

Discoverer

Morgan and Bridges, 22nd Nov. 1912.

Etymology

Identification

External Crossreferences and Linkouts ( 53 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34179

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0262029

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0262029

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

d_1
d_2

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG42840

FlyMine - An integrated database for Drosophila genomics

FBgn0262029

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34179

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC032522

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG42840

modMine - A data warehouse for the modENCODE project

FBgn0262029

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0262029

DRSC - Results frm RNAi screens

FBgn0262029

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

34179

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Hippo signaling pathway - fly

MIST (genetic) - An integrated Molecular Interaction Database

d

MIST (protein-protein) - An integrated Molecular Interaction Database

d

Synonyms and Secondary IDs (22)

Reported As

Symbol Synonym

29C3-D1

(Oliver et al., 1999)

29CD

(Berg et al., 2001)

AAF52683

(Yamashita et al., 2000)

CG10595

(Petzoldt et al., 2012, Keleman et al., 2009.8.5, Perkins et al., 2009, Mao et al., 2006, Tzolovsky et al., 2002)

CG13087

(Ashwal-Fluss et al., 2014, Keleman et al., 2009.8.5)

CG31610

CG42840

(Hosono et al., 2015, FlyBase Genome Annotators, 2010, Ni et al., 2010.12.1)

D

(Fulford and McNeill, 2020, Fulford et al., 2018, Richardson and Portela, 2017, Misra and Irvine, 2016, Wittkorn et al., 2015, Bossuyt et al., 2014, Grifoni et al., 2013, Harvey and Hariharan, 2012, Halder and Johnson, 2011, Milton et al., 2010, Hariharan, 2006)

Dachs

(Misra and Irvine, 2019, Fallahi et al., 2016, Misra and Irvine, 2016, Irvine and Harvey, 2015, Matsui and Lai, 2013, Liu et al., 2012)

Dh

(Gou et al., 2018)

DmMyo20

(Cao et al., 2014)

Ds

(Pan et al., 2013)

Myo29D

(Tzolovsky et al., 2002, Tzolovsky, 2001.12.3)

Myo3A

(Kollmar, 2015.9.15)

anon-EST:Liang-1.78

clone 1.78

(Liang and Biggin, 1998)

dachs

(Montes and Morata, 2017, Su, 2015, Degoutin et al., 2013, Marcinkevicius and Zallen, 2013, Grusche et al., 2011, Feng and Irvine, 2007)

l(2)c00146

Name Synonyms

lethal (2) c00146

myosin 29D

(Millo et al., 2004)

unconventional myosin 29D

(Tzolovsky, 2001.12.3)

Secondary FlyBase IDs

FBgn0032045
FBgn0086896
FBgn0000410
FBgn0025975
FBgn0032046
FBgn0051610
FBgn0069196

Datasets (1)

Study focus (1)

Experimental Role

Project

Project Type

Title

bait_protein

Hippo_Pathway_interaction_map

interactome

Interaction map generated by purification of Hippo pathway factors, with identification of copurifying proteins by mass spectrometry.

References (161)