Gene model reviewed during 5.52
Interacts (via cytoplasmic region) with Myo31DF.
Phosphorylated by fj on Ser/Thr of cadherin domains.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ds using the Feature Mapper tool.
ds transcripts persist throughout embryogenesis and reappear in larvae and adults. They are expressed in ectodermally derived tissues. They are first detected in six weak epidermal stripes and a prominent stripe at the amnioproctodeal invagination during gastrulation. During germ band extension, they are present in 14 segmental stripes and in the procephalon. Prominent expression is observed in the extended germ band stage in the forming tracheal pits. At stage 14, expression is also observed in the anterior spiracles and in the primordial leg discs. By late stage 14, expression is observed in the nearly fused labial buds and at invagination of the maxillary segment, along the segmental folds, and probably in the apodemes. ds transcripts are also expressed in specific areas of the larval brain and imaginal discs. In the supraoesophageal ganglion, ds is expressed in two areas of the optic lobe and in a region that may correspond to the mushroom body. In imaginal discs, strong ds expression is observed frequently along the folds separating the anlagen of distinct imaginal structures. It is observed in limited regions of the eye-antennal, humeral, labial, genital, leg, wing, and haltere discs.
GBrowse - Visual display of RNA-Seq signalsView Dmel\ds in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: ds l(2)01855
Clonal analysis indicates that the ds/ft system and the stan/fz system act independently to confer planar cell polarity in the adult abdomen; each system confers and propagates polarity and can do so in the absence of the other.
The extracellular domain of the ds product in necessary for its planar cell polarity role in the wing.
ds is required for the proper orientation of of cell division during organ development, which determines organ shape.
Gradients of fj and ds expression appear to provide partially redundant positional information essential for specifying the polarisation axis in the eye. The fidelity of planar cell polarity in the eye appears to result from the combined action of the fj and ds gradients acting through ft.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
ds encodes a member of the cadherin superfamily that controls imaginal disc morphogenesis. The phenotypes of, and genetic interactions between ds and ft are consistent with a model in which cell proliferation and morphogenesis of imaginal structures depends on the coupled equilibria between homo- and heterophilic interactions of the ds and ft cadherin proteins.
"G00608; BDGP:Dm0344 ; BDGP:l (2)05142" was stated as revision.