FlyBase Allele Report: Dmel\ds[HMS00759]

General Information

Symbol

Dmel\ds^HMS00759

Species

D. melanogaster

Name

FlyBase ID

FBal0257442

Feature type

allele

Associated gene

Dmel\ds

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00759}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00759}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00759

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of obesity

CEA

(Agrawal et al., 2021)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity | adult stage, with Scer\GAL4^ptc.PU

(Wang et al., 2017)

increased body weight | adult stage, with Scer\GAL4^Tub.PU

(Agrawal et al., 2021)

visible | adult stage, with Scer\GAL4^ptc.PU

(Wang et al., 2017)

Phenotype Manifest In

abdominal sternite bristle, with Scer\GAL4^ptc.PU

(Wang et al., 2017)

Detailed Description

Statement

Reference

Expression of ds^HMS00759 under the control of Scer\GAL4^ptc.PU leads to defects in polarity of abdominal bristles in adult flies.

(Wang et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Scer\GAL4^repo.PU/ds^HMS00759 is a non-enhancer of increased size | larval stage phenotype of Scer\GAL4^repo.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

Scer\GAL4^elav.PU/ds^HMS00759 is a non-enhancer of increased size | larval stage phenotype of Scer\GAL4^elav.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

ds^HMS00759/Scer\GAL4^ptc.PU is a non-enhancer of visible | adult stage phenotype of frtz³⁰

(Wang et al., 2017)

ds^HMS00759/Scer\GAL4^ptc.PU is a non-enhancer of abnormal planar polarity | adult stage phenotype of frtz³⁰

(Wang et al., 2017)

ds^HMS00759/Scer\GAL4^ptc.PU is a non-enhancer of visible | adult stage phenotype of fy²

(Wang et al., 2017)

ds^HMS00759/Scer\GAL4^ptc.PU is a non-enhancer of abnormal planar polarity | adult stage phenotype of fy²

(Wang et al., 2017)

NOT Suppressor of

Statement

Reference

Scer\GAL4^repo.PU/ds^HMS00759 is a non-suppressor of increased size | larval stage phenotype of Scer\GAL4^repo.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

Scer\GAL4^elav.PU/ds^HMS00759 is a non-suppressor of increased size | larval stage phenotype of Scer\GAL4^elav.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

ds^HMS00759, Scer\GAL4^ap-md544 is a non-suppressor of neoplasia | larval stage phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691

(Fereres et al., 2019)

ds^HMS00759, Scer\GAL4^ap-md544 is a non-suppressor of increased cell number | larval stage phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691

(Fereres et al., 2019)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Scer\GAL4^repo.PU/ds^HMS00759 is a non-enhancer of larval ventral nerve cord phenotype of Scer\GAL4^repo.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

Scer\GAL4^elav.PU/ds^HMS00759 is a non-enhancer of larval ventral nerve cord phenotype of Scer\GAL4^elav.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

ds^HMS00759/Scer\GAL4^ptc.PU is a non-enhancer of abdominal sternite bristle phenotype of frtz³⁰

(Wang et al., 2017)

ds^HMS00759/Scer\GAL4^ptc.PU is a non-enhancer of abdominal sternite bristle phenotype of fy²

(Wang et al., 2017)

NOT Suppressor of

Statement

Reference

Scer\GAL4^repo.PU/ds^HMS00759 is a non-suppressor of larval ventral nerve cord phenotype of Scer\GAL4^repo.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

Scer\GAL4^elav.PU/ds^HMS00759 is a non-suppressor of larval ventral nerve cord phenotype of Scer\GAL4^elav.PU, kon^{UAS.Tag:HA,Tag:SS(wg)}

(Harrison et al., 2021)

ds^HMS00759, Scer\GAL4^ap-md544 is a non-suppressor of wing disc phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544, psq^KK111691

(Fereres et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

All larvae co-expressing psq^KK111691 and Egfr^UAS.cBa under the control of Scer\GAL4^ap-md544 during larval stages (using Gal80[ts] for the temporal regulation of expression) wing discs tumors, associated with higher numbers of myoblasts. These phenotypes are not suppressed by the co-expression of ds^HMS00759 under the control of Ecol\lexA^GMR15B03.

(Fereres et al., 2019)

Either fy² or frtz³⁰ mutants also expressing ds^HMS00759 under the control of the Scer\GAL4^ptc.PU driver display hair polarity defects in abdominal bristles that are similarly severe as in fy² or frtz³⁰ single mutants, respectively.

(Wang et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

32964