FlyBase Gene Report: Dmel\CadN

General Information

Symbol

Dmel\CadN

Species

D. melanogaster

Name

Cadherin-N

Annotation Symbol

CG7100

Feature Type

protein_coding_gene

FlyBase ID

FBgn0015609

Gene Model Status

Current

Stock Availability

151 publicly available

Gene Summary

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May associate with arm neural isoform and participate in the transmission of developmental information. (UniProt, O15943)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

N-cadherin, DN-cadherin, Ncad, N-Cad, DN-Cad

Key Links

Genomic Location

Cytogenetic map

36D1-36D3

Sequence location

2L:17,647,053..17,778,340 [-]

Recombination map

2-53

RefSeq locus

NT_033779 REGION:17647053..17778340

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (26 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

enables cadherin binding

inferred from physical interaction with FLYBASE:CadN; FB:FBgn0015609

(Jin et al., 2012)

enables calcium ion binding

inferred from direct assay

(Jin et al., 2012)

enables protein binding

inferred from physical interaction with UniProtKB:P18824-2

(Loureiro and Peifer, 1998)

enables protein homodimerization activity

inferred from physical interaction with FLYBASE:CadN; FB:FBgn0015609

(Jin et al., 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables calcium ion binding

inferred from electronic annotation with InterPro:IPR000233, InterPro:IPR001881, InterPro:IPR002126, InterPro:IPR015919

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN001931974

(GO Reference Genome Project, 2011-)

Biological Process (17 terms)

Terms Based on Experimental Evidence (14 terms)

CV Term

Evidence

References

involved_in axon extension involved in axon guidance

inferred from mutant phenotype

(Prakash et al., 2005)

involved_in axon extension

inferred from mutant phenotype

(Prakash et al., 2009)

involved_in axon guidance

inferred from mutant phenotype

(Tong et al., 2011, Prakash et al., 2009)

inferred from genetic interaction with FLYBASE:uzip; FB:FBgn0004055

(Ding et al., 2011)

involved_in axon target recognition

inferred from mutant phenotype

(Lee et al., 2001)

involved_in calcium-dependent cell-cell adhesion

inferred from physical interaction with FLYBASE:arm; FB:FBgn0000117

(Iwai et al., 1997)

inferred from physical interaction with FLYBASE:α-Cat; FB:FBgn0010215

(Iwai et al., 1997)

involved_in cell-cell adhesion mediated by cadherin

inferred from direct assay

(Yonekura et al., 2007)

involved_in homophilic cell-cell adhesion

inferred from direct assay

(Yonekura et al., 2007, Iwai et al., 1997)

involved_in negative regulation of dendrite morphogenesis

inferred from mutant phenotype

(Zhu and Luo, 2004)

involved_in ommatidial rotation

inferred from mutant phenotype

(Mirkovic and Mlodzik, 2006)

involved_in R7 cell development

inferred from mutant phenotype

(Tong et al., 2011, Nern et al., 2008, Petrovic and Hummel, 2008, Yonekura et al., 2007)

involved_in R8 cell development

inferred from mutant phenotype

(Nern et al., 2008, Yonekura et al., 2007)

involved_in regulation of axon extension involved in axon guidance

inferred from mutant phenotype

(Prakash et al., 2009)

involved_in regulation of dendrite morphogenesis

inferred from mutant phenotype

(Hasegawa et al., 2011)

involved_in retinal ganglion cell axon guidance

inferred from mutant phenotype

(Choe et al., 2006)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in axonal fasciculation

traceable author statement

(Chiba, 1999)

involved_in calcium-dependent cell-cell adhesion

inferred from sequence or structural similarity with FLYBASE:shg; FB:FBgn0003391

(Iwai et al., 1997)

inferred from sequence or structural similarity with MGI:MGI:88355

(Iwai et al., 1997)

involved_in cell adhesion

inferred from electronic annotation with InterPro:IPR020894

(InterPro Project Members, 2004-)

involved_in cell-cell adhesion

inferred from electronic annotation with InterPro:IPR039808

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN001931974

(GO Reference Genome Project, 2011-)

involved_in homophilic cell-cell adhesion

inferred from electronic annotation with InterPro:IPR000233, InterPro:IPR002126

(InterPro Project Members, 2004-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in axon

inferred from direct assay

(Hsu et al., 2009)

located_in cell-cell junction

inferred from direct assay

(Iwai et al., 1997)

located_in dendrite

inferred from direct assay

(Hsu et al., 2009)

located_in plasma membrane

inferred from direct assay

(Melani et al., 2008)

inferred from direct assay

(Dottermusch-Heidel et al., 2012, Biersmith et al., 2011)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in cell-cell junction

inferred from biological aspect of ancestor with PANTHER:PTN001931974

(GO Reference Genome Project, 2011-)

located_in membrane

inferred from sequence or structural similarity with MGI:MGI:88355

(Iwai et al., 1997)

inferred from electronic annotation with InterPro:IPR002126, InterPro:IPR015919

(InterPro Project Members, 2004-)

located_in plasma membrane

inferred from sequence or structural similarity with FLYBASE:shg; FB:FBgn0003391

(Iwai et al., 1997)

inferred from electronic annotation with InterPro:IPR020894

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

CADHERINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CADHERINS -: The cadherin superfamily represent a diverse group of transmembrane receptors which mediate cell-cell adhesion. Cadherins are defined by the presence of cadherin domains, typically organised in tandem repeats, which mediate calcium-dependent homophilic interactions between cadherin molecules. (Adapted from FBrf0146675).

Protein Function (UniProtKB)

(UniProt, O15943)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

l(2)36Da

Larval lethal.

Summary (Interactive Fly)

cadherin - cell aggregation - regulates axon pathfinding - sequoia-induced axon targeting is mediated - through the ubiquitously expressed Cadherin-N cell adhesion molecule - Cooperates with E-cadherin to regulate the cell motility process of ommatidial rotation

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CadN for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry O15943)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CadN-RA

FBtr0081013

NM_165229

10412

3096

CadN-RB

FBtr0081020

NM_165225

10412

3096

CadN-RC

FBtr0081014

NM_165228

10409

3095

CadN-RD

FBtr0081015

NM_165227

13384

3097

CadN-RE

FBtr0081016

NM_165231

13228

3097

CadN-RF

FBtr0081017

NM_165226

10412

3096

CadN-RG

FBtr0081018

NM_165230

10412

3096

CadN-RH

FBtr0081019

NM_165224

10409

3095

CadN-RI

FBtr0100313

NM_001032109

13237

3100

CadN-RJ

FBtr0100314

NM_001032108

10421

3099

CadN-RK

FBtr0100315

NM_001032107

13237

3100

CadN-RL

FBtr0100316

NM_001032106

10427

3101

Additional Transcript Data and Comments

Reported size (kB)

15 (northern blot)

(Iwai et al., 1997)

>10 (northern blot)

(Casal and Leptin, 1996)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CadN-PA

FBpp0080566

346.7

3096

4.64

NP_724073

AAN10996

CadN-PB

FBpp0080573

346.9

3096

4.64

NP_724069

AAN10993

CadN-PC

FBpp0080567

346.5

3095

4.68

NP_724072

AAN10995

CadN-PD

FBpp0080568

347.2

3097

4.67

FBpp0080569

347.1

3097

4.67

NP_724075

AAN10998

CadN-PF

FBpp0080570

347.0

3096

4.71

NP_724070

AAN10994

CadN-PG

FBpp0080571

346.8

3096

4.71

NP_724074

AAN10997

CadN-PH

FBpp0080572

346.6

3095

4.68

NP_724068

AAN10992

CadN-PI

FBpp0099718

347.2

3100

4.64

FBpp0099719

346.9

3099

4.68

FBpp0099720

347.3

3100

4.71

FBpp0099721

347.5

3101

4.67

Q4ABE7

NP_001027277

AAZ66476

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

3097 (aa); 300 (kD observed)

(Iwai et al., 1997)

Comments

External Data

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

(UniProt, O15943)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CadN using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.46

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 5

mesoderm anlage

(Casal and Leptin, 1996)

embryonic stage 6 -- 17

mesoderm

(Casal and Leptin, 1996)

embryonic stage 11 -- 17

larval ventral nerve cord

(Casal and Leptin, 1996)

oogenesis stage S1 -- S9

follicle cell

(Zartman et al., 2009)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Iwai et al., 1997)

larval neuron

(Iwai et al., 1997)

mesoderm

(Iwai et al., 1997)

Additional Descriptive Data

CadN transcripts are first seen in nuclei of presumptive mesodermal cells prior to stage 5. Transport to the cytoplasm begins at around stage 6-7. By stage 8, transcripts are distributed throughout the nucleus.

(Zartman et al., 2009, Iwai et al., 1997)

CadN transcripts are most abundant in embryos on northern blots. CadN transcripts are expressed in developing neural cells, presumably at their postmitotic stage.

(Iwai et al., 1997)

Marker for

Subcellular Localization

CV Term

cytoplasm

nucleus

(Iwai et al., 1997)

Polypeptide Expression

immuno-electron microscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

optic cartridge

• synaptic membrane

(Iwai et al., 2002)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

larval posterior commissure

(Iwai et al., 1997)

myoblast

(Iwai et al., 1997)

larval longitudinal connective

(Iwai et al., 1997)

larval anterior commissure

(Iwai et al., 1997)

presumptive embryonic/larval nervous system

(Iwai et al., 1997)

neuron

• axon

(Iwai et al., 1997)

motor neuron

(Iwai et al., 1997)

embryonic stage 9 -- 17

mesoderm

(Iwai et al., 1997)

embryonic stage 16

larval intersegmental nerve

(Kurusu et al., 2012)

larval segmental nerve

(Kurusu et al., 2012)

larval intersegmental nerve branch ISNb of A1-7

(Kurusu et al., 2012)

first instar larval stage

calyx of larval mushroom body | intense

(Gross et al., 2013)

embryonic/larval mushroom body

(Gross et al., 2013)

first instar larval stage -- third instar larval stage

neuron of mushroom body | faint

(Kurusu et al., 2012)

second instar larval stage | male & third instar larval stage | male

neuron of mushroom body | subset

(Kurusu et al., 2012)

third instar larval stage

photoreceptor neuron

• axon

(Iwai et al., 1997)

embryonic precursor cell of adult muscle

(Iwai et al., 1997)

ommatidial precursor cluster

(Iwai et al., 2002)

eye photoreceptor cell

• axon

(Iwai et al., 2002)

larval neuron | subset of medulla anlage

• cell body

(Hasegawa et al., 2011)

calyx of larval mushroom body | intense

(Gross et al., 2013)

embryonic/larval mushroom body

(Gross et al., 2013)

neuron of core layer of the larval mushroom body | subset

• axon

(Kurusu et al., 2012)

type I bouton | subset

(Kurusu et al., 2012)

embryonic/larval neuromuscular junction

• type Ib terminal bouton

(Kurusu et al., 2012)

tarsal segment 5

(Tajiri et al., 2007)

early third instar larval stage

pretarsus

(Tajiri et al., 2007)

pupal stage

cone cell

• adherens junction

(Hayashi and Carthew, 2004)

cone cell

• adherens junction

(Hayashi and Carthew, 2004)

pupal stage P6 -- pharate adult stage P11

outer medulla | restricted

(Nern et al., 2008)

pupal stage P6 -- pharate adult stage P14

lamina monopolar neuron

Comment: growth cone

(Nern et al., 2008)

pupal stage P7

lamina

Comment: reference states 40% pupal development

(Iwai et al., 2002)

medulla

Comment: reference states 40% pupal development

(Iwai et al., 2002)

pharate adult stage P11 -- P14

medulla layer M2

(Nern et al., 2008)

pharate adult stage P11 -- adult stage

optic cartridge

Comment: reference states 75% pupal development

(Iwai et al., 2002)

adult stage

mushroom body modulatory input neuron | restricted

• synapse

Comment: postsynaptic localization

(Kurusu et al., 2012)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Axons in the core layer of the larval mushroom body of first and second instar larvae intensely expressed CadN, while expression in surrounding mature axons was much weaker.

(Kurusu et al., 2012)

Strong CadN immunoreactivity was detected in the cell bodies of developing MB neurons, as well as in the core axons of peduncles and lobes. In contrast, CadN expression was dramatically downregulated in the cell bodies of mature neurons, and in axons located at the periphery of the peduncles and lobes. In the adults, all mature MB neurons exhibited reduced expression of CadN.

(Kurusu et al., 2012)

CadN signals straddle the region between the mushroom body dendritic regions and the presynaptic fields of olfactory projection neurons labeled with anti-Syn.

(Kurusu et al., 2012)

CadN protein is expressed in the cell bodies of neurons of the medulla anlage in third instar larva, but it is more strongly expressed in the inner domain, where hth is expressed.

(Hasegawa et al., 2011)

At 25 hr APF, CadN is strongly expressed between the R7 and R8 growth cones that mark the boundaries of the outer medulla at this stage. By 48 hr APF, the region has divided into two CadN-rich regions divided by a zone of weaker staining. At 75 hr APF prominent CadN expression is seen in a single layer in the distal part of the outer medulla. Strong CadN expression is seen in M2 in later pual stages. CadN is strongly expressed on growth cones of lamina neurons during development.

(Nern et al., 2008)

Distal CadN expression was first faintly

(Tajiri et al., 2007)

detected in the future pretarsus region. These pretarsus signals became stronger during early third instar. CadN expression in tarsal segment 5 could be discerned in the region surrounding the central pretarsus expression domain from mid-third instar onwards.

(Tajiri et al., 2007)

CadN is localized to the adherens junctions of the cell-cell interfaces of cone cells.

(Hayashi and Carthew, 2004)

In adults, immunogold-labeled antibodies to CadN cluster at the periphery of the synaptic cleft, juxtaposed to the active zones, in the optic cartridges. The affected synapses appear to be between R1--R6 axons and spines of L-cells (lamina monopolar neurons).

(Iwai et al., 2002)

Marker for

cone cell

(Hayashi and Carthew, 2004)

Subcellular Localization

CV Term

Evidence

References

located_in axon

inferred from direct assay

(Hsu et al., 2009)

located_in cell-cell junction

inferred from direct assay

(Iwai et al., 1997)

located_in dendrite

inferred from direct assay

(Hsu et al., 2009)

located_in plasma membrane

inferred from direct assay

(Melani et al., 2008)

inferred from direct assay

(Dottermusch-Heidel et al., 2012, Biersmith et al., 2011)

Expression Deduced from Reporters

Reporter: P{ST.lexA::HG}CadN^LH-3

Stage

Tissue/Position (including subcellular localization)

Reference

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CadN in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CadN

View exonic expression by tissue for Dmel\CadN

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35070/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015609

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015609

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015609

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7100

Flygut - An atlas of the Drosophila adult midgut

FBgn0015609

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 45 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 23 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CadN

Transgenic constructs containing regulatory region of CadN

Aberrations (Deficiencies and Duplications) ( 38 )

Inferred from experimentation ( 38 )

Gene disrupted in

Df(2L)A33

(Hardy, 2005.6.1)

Df(2L)BSC148

(Christensen and Cook, 2006.3.8)

Df(2L)Δ6

(Prakash et al., 2005)

Df(2L)Δ12

(Prakash et al., 2005)

Df(2L)E48

(Schäfer et al., 2014)

Df(2L)Exel7069

(Ryder, 2004.4.26)

Df(2L)H20

(Brumby et al., 2004, Steward and Nusslein-Volhard, 1986)

Df(2L)H68

(Steward and Nusslein-Volhard, 1986)

Df(2L)I131

(Hardy, 2005.6.1)

Df(2L)M36F18

(Steward and Nusslein-Volhard, 1986)

Df(2L)M36F-S5

(Brumby et al., 2004, Iwai et al., 1997, Steward and Nusslein-Volhard, 1986)

Df(2L)T317

(Caldwell et al., 2007, Steward and Nusslein-Volhard, 1986)

Df(2L)TW119

(Caldwell et al., 2007, Iwai et al., 1997, Steward and Nusslein-Volhard, 1986, Wright et al., 1976)

Df(2L)TW137

(Brumby et al., 2004, Steward and Nusslein-Volhard, 1986, Wright et al., 1976)

Df(2L)TW330

(Steward and Nusslein-Volhard, 1986)

Df(2L)VA18

(Steward and Nusslein-Volhard, 1986)

Gene partially disrupted in

Df(2L)CadN^Δ4

(Prakash et al., 2005)

Df(2L)CadN^Δ14

(Prakash et al., 2005)

Inferred from location ( 2 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

lethal - all die before end of pupal stage

CadN^Δ18A

lethal - all die during embryonic stage (with CadN⁴⁰⁵)

CadN^M19

lethal - all die during embryonic stage (with CadN^M19)

CadN⁴⁰⁵

lethal - all die during embryonic stage | recessive

CadN^M19

lethal - all die during larval stage, with Scer\GAL4^how-24B

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CadN^GD161

viable, with Scer\GAL4^Mef2.PR

CadN^GD161

viable, with Scer\GAL4^pnr-MD237

CadN^GD161

viable, with Scer\GAL4^tin.CΔ4

CadN^GD161

Sterility

Allele

sterile, with CadN⁴⁰⁵/CadN^M19, Scer\GAL4^elav.PU

sterile (with CadN⁴⁰⁵), with CadN^{7b-13a-18a.UAS}, Scer\GAL4^elav.PU

CadN^M19

sterile (with CadN⁴⁰⁵), with CadN^{7b-13b-18a.UAS}, Scer\GAL4^elav.PU

CadN^M19

sterile (with CadN^M19), with CadN^{7b-13a-18a.UAS}, Scer\GAL4^elav.PU

CadN⁴⁰⁵

sterile (with CadN^M19), with CadN^{7b-13b-18a.UAS}, Scer\GAL4^elav.PU

CadN⁴⁰⁵

Other Phenotypes

Allele

abnormal body size | larval stage, with Scer\GAL4^how-24B

abnormal cell polarity, with Scer\GAL4^hs.2sev

CadN^UAS.cIa

abnormal cell polarity | somatic clone, with Scer\GAL4^hs.2sev

CadN^UAS.cIa

abnormal courtship behavior | male, with Scer\GAL4^fru.P1.D

abnormal locomotor behavior

CadN^M12

abnormal locomotor behavior | larval stage, with Scer\GAL4^how-24B

abnormal neuroanatomy

abnormal neuroanatomy | adult stage, with Scer\FLP1^FLPo.ato, Scer\GAL4^FRT.Act5C

CadN^RNAi.UAS.cUa

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR9B08

CadN^RNAi.UAS.cUa

abnormal neuroanatomy | adult stage | somatic clone

abnormal neuroanatomy | larval stage, with Scer\GAL4^bsh.M.PT

CadN^UAS.cIa

abnormal neuroanatomy | larval stage, with Scer\GAL4^sens.F2

abnormal neuroanatomy | larval stage, with Scer\GAL4^sev.PM181

abnormal neuroanatomy | larval stage | somatic clone

CadN^M19

abnormal neuroanatomy | larval stage | somatic clone, with Scer\FLP1^G5.20C11, Scer\GAL4^GMR.PC

abnormal neuroanatomy | larval stage | somatic clone, with Scer\FLP1^G5.sens.PC, Scer\GAL4^GMR.PC

abnormal neuroanatomy | larval stage | somatic clone, with Scer\GAL4^bsh.M.PT

CadN^UAS.cIa

abnormal neuroanatomy | larval stage | somatic clone, with Scer\GAL4^GMR.PC

CadN^JF02653

abnormal neuroanatomy | P-stage | somatic clone

CadN^Δ14

abnormal neuroanatomy | pupal stage | somatic clone

CadN^Δ14

abnormal neuroanatomy | recessive | somatic clone

abnormal neuroanatomy | somatic clone

abnormal neuroanatomy | somatic clone, with Scer\GAL4^GH146

CadN^UAS.cIa

abnormal optomotor response

abnormal optomotor response | somatic clone

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CadN^GD161

decreased cell number, with Scer\GAL4^NP7397

CadN^NIG.7100R

decreased cell number | adult stage

CadN^M12

some die during embryonic stage | recessive

CadN^M19

some die during pupal stage

CadN^Δ18A

uncoordinated

CadN^M12

visible, with Scer\GAL4^pnr-MD237

CadN^GD161

Phenotype manifest in

Allele

adult antennal lobe, with Scer\FLP1^FLPo.ato, Scer\GAL4^FRT.Act5C

CadN^RNAi.UAS.cUa

adult antennal lobe glomerulus, with Scer\FLP1^FLPo.ato, Scer\GAL4^FRT.Act5C

CadN^RNAi.UAS.cUa

adult brain | somatic clone

adult olfactory receptor neuron Or67d, with Scer\FLP1^FLPo.ato, Scer\GAL4^FRT.Act5C

CadN^RNAi.UAS.cUa

adult olfactory receptor neuron Or88a, with Scer\FLP1^FLPo.ato, Scer\GAL4^FRT.Act5C

CadN^RNAi.UAS.cUa

antennal lobe glomerulus | somatic clone

antennal lobe glomerulus DA1 | somatic clone

CadN^M19

antennal lobe glomerulus DL1 | somatic clone

CadN^M19

antennal lobe glomerulus DL3 | somatic clone

CadN^M19

antennal lobe glomerulus VM7 | somatic clone

CadN^M19

axon terminus | larval stage, with Scer\GAL4^bsh.M.PT

CadN^UAS.cIa

axon terminus | larval stage, with Scer\GAL4^sens.F2

axon terminus | larval stage, with Scer\GAL4^sev.PM181

axon terminus | larval stage | somatic clone

CadN^M19

axon terminus | larval stage | somatic clone, with Scer\FLP1^G5.20C11, Scer\GAL4^GMR.PC

axon terminus | larval stage | somatic clone, with Scer\FLP1^G5.sens.PC, Scer\GAL4^GMR.PC

axon terminus | larval stage | somatic clone, with Scer\GAL4^bsh.M.PT

CadN^UAS.cIa

axon terminus | larval stage | somatic clone, with Scer\GAL4^GMR.PC

CadN^JF02653

cone cell | cell non-autonomous | somatic clone, with Scer\GAL4^Act5C.PI

CadN^UAS.cIa

cone cell | somatic clone

CadN^M19

cyst progenitor cell | adult stage

CadN^M12

dMP2 neuron

CadN^M19

eye photoreceptor cell

CadN^Δ14

eye photoreceptor cell & axon | somatic clone | cell autonomous

CadN^unspecified

hub cell | adult stage

CadN^M12

inner medulla | adult stage | somatic clone

inner medulla | P-stage | somatic clone

CadN^Δ14

lamina

CadN^Δ14

lamina monopolar neuron

lamina monopolar neuron L1 | adult stage | somatic clone

CadN^Δ14

lamina monopolar neuron L1 | P-stage | somatic clone

CadN^Δ14

lamina monopolar neuron L2 | adult stage | somatic clone

CadN^Δ14

lamina monopolar neuron L3 | adult stage, with Scer\GAL4^GMR9B08

CadN^RNAi.UAS.cUa

lamina monopolar neuron L3 | adult stage | somatic clone

lamina monopolar neuron L3 | P-stage | somatic clone

CadN^Δ14

lamina monopolar neuron L4 | adult stage | somatic clone

CadN^Δ14

lamina monopolar neuron L5 | P-stage | somatic clone

CadN^Δ14

lamina monopolar neuron L5 | somatic clone

CadN^M19

lamina plexus | somatic clone

CadN⁴⁰⁵

larval anterior commissure

CadN^M19

larval longitudinal connective

CadN^M19

larval MP1 neuron

CadN^M19

lateral longitudinal fascicle

CadN⁴⁰⁵

male accessory gland secondary cell, with Scer\GAL4^NP7397

CadN^NIG.7100R

male germline stem cell | adult stage

CadN^M12

medulla

medulla | larval stage, with Scer\GAL4^bsh.M.PT

CadN^UAS.cIa

medulla | larval stage, with Scer\GAL4^sens.F2

medulla | larval stage, with Scer\GAL4^sev.PM181

CadN^GD161

medulla | larval stage | somatic clone

CadN^M19

medulla | larval stage | somatic clone, with Scer\FLP1^G5.20C11, Scer\GAL4^GMR.PC

medulla | larval stage | somatic clone, with Scer\FLP1^G5.sens.PC, Scer\GAL4^GMR.PC

medulla | larval stage | somatic clone, with Scer\GAL4^bsh.M.PT

CadN^UAS.cIa

medulla | larval stage | somatic clone, with Scer\GAL4^GMR.PC

CadN^JF02653

medulla | somatic clone

CadN⁴⁰⁵

medulla intrinsic neuron Mi1 | larval stage, with Scer\GAL4^bsh.M.PT

CadN^UAS.cIa

medulla intrinsic neuron Mi1 | larval stage, with Scer\GAL4^sev.PM181

CadN^GD161

medulla intrinsic neuron Mi1 | larval stage | somatic clone, with Scer\GAL4^bsh.M.PT

CadN^UAS.cIa

medulla intrinsic neuron Mi1 | somatic clone

medulla layer M2 | somatic clone

CadN^M19

medulla layer M3

CadN⁴⁰⁵

medulla layer M5 | somatic clone

CadN^M19

medulla layer M6

CadN⁴⁰⁵

medulla layer M6 | adult stage | somatic clone

medulla layer M6 | P-stage | somatic clone

CadN^Δ14

medulla layer M10 | somatic clone

CadN^M19

mesonotum, with Scer\GAL4^pnr-MD237

CadN^GD161

MP1 tract

CadN^M19

olfactory receptor neuron | somatic clone

ommatidial precursor cluster, with Scer\GAL4^hs.2sev

CadN^UAS.cIa

ommatidium | somatic clone, with Scer\GAL4^hs.2sev

CadN^UAS.cIa

optic cartridge

CadN^Δ14

outer medulla | adult stage | somatic clone

CadN^Δ14

photoreceptor cell R1 & axon | somatic clone

CadN^unspecified

photoreceptor cell R2 & axon | somatic clone

CadN^unspecified

photoreceptor cell R3 & axon | somatic clone

CadN^unspecified

photoreceptor cell R4 & axon | somatic clone

CadN^unspecified

photoreceptor cell R4 | cell non-autonomous | somatic clone

CadN^Δ14

photoreceptor cell R4 | pupal stage | somatic clone

CadN^Δ14

photoreceptor cell R4 | somatic clone

CadN⁴⁰⁵

photoreceptor cell R5 & axon | somatic clone

CadN^unspecified

photoreceptor cell R6 & axon | somatic clone

CadN^unspecified

photoreceptor cell R7

photoreceptor cell R7 & axon | somatic clone

CadN^unspecified

photoreceptor cell R7 | larval stage, with Scer\GAL4^sens.F2

CadN^UAS.cIa

photoreceptor cell R7 | larval stage, with Scer\GAL4^sev.PM181

photoreceptor cell R7 | larval stage | somatic clone

CadN^M19

photoreceptor cell R7 | larval stage | somatic clone, with Scer\FLP1^G5.20C11, Scer\GAL4^GMR.PC

photoreceptor cell R7 | somatic clone

photoreceptor cell R8 | larval stage, with Scer\GAL4^sens.F2

photoreceptor cell R8 | larval stage, with Scer\GAL4^sev.PM181

photoreceptor cell R8 | larval stage | somatic clone

CadN^M19

photoreceptor cell R8 | larval stage | somatic clone, with Scer\FLP1^G5.sens.PC, Scer\GAL4^GMR.PC

photoreceptor cell R8 | somatic clone

CadN⁴⁰⁵

photoreceptor neuron | pupal stage | somatic clone

CadN^Δ14

photoreceptor neuron | somatic clone

CadN^Δ18A

presumptive embryonic/larval central nervous system

CadN^M19

primary pigment cell | somatic clone, with Scer\GAL4^Act5C.PI

CadN^UAS.cIa

vMP2 neuron

CadN^M19

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (69)

Hsap\CDH1

2 of 14

Yes

Hsap\CDH2

2 of 14

Yes

Hsap\CDH4

2 of 14

Yes

Hsap\CDH5

2 of 14

Yes

Hsap\CDH6

2 of 14

Yes

Hsap\CDH7

2 of 14

Yes

Hsap\CDH8

2 of 14

Yes

Hsap\CDH9

2 of 14

Yes

Hsap\CDH10

2 of 14

Yes

Hsap\CDH11

2 of 14

Yes

Hsap\CDH12

2 of 14

Yes

Hsap\CDH15

2 of 14

Yes

Hsap\CDH18

2 of 14

Yes

Hsap\CDH19

2 of 14

Yes

Hsap\CDH20

2 of 14

Yes

Hsap\CDH22

2 of 14

Yes

Hsap\CDH23

2 of 14

Yes

Hsap\CDH24

2 of 14

Yes

Hsap\DCHS1

2 of 14

Yes

Hsap\DCHS2

2 of 14

Yes

Hsap\DSC1

2 of 14

Yes

Hsap\FAT1

2 of 14

Yes

Hsap\FAT2

2 of 14

Yes

Hsap\FAT3

2 of 14

Yes

Hsap\FAT4

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\DSC3

1 of 14

Yes

Hsap\DSG1

1 of 14

Yes

Hsap\DSG2

1 of 14

Yes

Hsap\DSG3

1 of 14

Yes

Hsap\DSG4

1 of 14

Yes

Hsap\EGFLAM

1 of 14

Hsap\EREG

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\PCDHGA9

1 of 14

Yes

Hsap\SLIT1

1 of 14

Hsap\SLIT2

1 of 14

Hsap\SLIT3

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (48)

Rnor\Cdh1

2 of 14

Yes

Rnor\Cdh2

2 of 14

Yes

Rnor\Cdh6

2 of 14

Yes

Rnor\Cdh7

2 of 14

Yes

Rnor\Cdh8

2 of 14

Yes

Rnor\Cdh9

2 of 14

Yes

Rnor\Cdh10

2 of 14

Yes

Rnor\Cdh11

2 of 14

Yes

Rnor\Cdh12

2 of 14

Yes

Rnor\Cdh15

2 of 14

Yes

Rnor\Cdh18

2 of 14

Yes

Rnor\Cdh19

2 of 14

Yes

Rnor\Cdh20

2 of 14

Yes

Rnor\Cdh22

2 of 14

Yes

Rnor\Cdh24

2 of 14

Yes

Rnor\Dchs1

2 of 14

Yes

Rnor\Fat1

2 of 14

Yes

Rnor\Fat2

2 of 14

Yes

Rnor\Fat3

2 of 14

Yes

Rnor\Fat4

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (76)

Mmus\Cdh1

2 of 14

Yes

Mmus\Cdh2

2 of 14

Yes

Mmus\Cdh4

2 of 14

Yes

Mmus\Cdh6

2 of 14

Yes

Mmus\Cdh7

2 of 14

Yes

Mmus\Cdh8

2 of 14

Yes

Mmus\Cdh9

2 of 14

Yes

Mmus\Cdh10

2 of 14

Yes

Mmus\Cdh11

2 of 14

Yes

Mmus\Cdh12

2 of 14

Yes

Mmus\Cdh18

2 of 14

Yes

Mmus\Cdh19

2 of 14

Yes

Mmus\Cdh20

2 of 14

Yes

Mmus\Cdh22

2 of 14

Yes

Mmus\Cdh24

2 of 14

Yes

Mmus\Dchs1

2 of 14

Yes

Mmus\Dchs2

2 of 14

Yes

Mmus\Fat1

2 of 14

Yes

Mmus\Fat2

2 of 14

Yes

Mmus\Fat3

2 of 14

Yes

Mmus\Fat4

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Egfl6

1 of 14

Yes

Mmus\Egflam

1 of 14

Mmus\Ereg

1 of 14

Yes

Mmus\Gm37013

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Pcdh12

1 of 14

Yes

Mmus\Pcdh18

1 of 14

Yes

Mmus\Pcdh19

1 of 14

Yes

Mmus\Pcdha3

1 of 14

Yes

Mmus\Pcdha4

1 of 14

Yes

Mmus\Pcdha7

1 of 14

Yes

Mmus\Pcdha8

1 of 14

Yes

Mmus\Pcdha9

1 of 14

Yes

Mmus\Pcdha10

1 of 14

Yes

Mmus\Pcdha12

1 of 14

Yes

Mmus\Pcdhga1

1 of 14

Yes

Mmus\Pcdhga4

1 of 14

Yes

Mmus\Pcdhga10

1 of 14

Yes

Mmus\Pcdhgb1

1 of 14

Yes

Mmus\Pcdhgb2

1 of 14

Yes

Mmus\Pcdhgb4

1 of 14

Yes

Mmus\Pcdhgb7

1 of 14

Yes

Mmus\Pcdhgc3

1 of 14

Yes

Mmus\Pcdhgc4

1 of 14

Yes

Mmus\Pcdhgc5

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (41)

Xtro\LOC100493382

10 of 13

Yes

Xtro\LOC100494953

6 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\cdh23

1 of 13

Xtro\cdh24

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (57)

Drer\si:ch211-186j3.6

13 of 14

Yes

Drer\si:dkey-22o22.2

11 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\slit1a

1 of 14

Drer\slit1b

1 of 14

Drer\slit2

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (14)

Cele\hmr-1

11 of 14

Yes

Cele\cdh-4

3 of 14

Cele\cdh-1

2 of 14

Cele\Y52B11A.11

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\lin-12

1 of 14

Cele\mab-7

1 of 14

Yes

Cele\nlr-1

1 of 14

Cele\nrx-1

1 of 14

Anopheles gambiae (African malaria mosquito) (30)

Agam\AgaP_AGAP009716

5 of 12

Yes

Agam\AgaP_AGAP009717

5 of 12

Yes

Agam\AgaP_AGAP009723

5 of 12

Yes

Agam\AgaP_AGAP009726

5 of 12

Yes

Agam\AgaP_AGAP009711

4 of 12

Yes

Agam\AgaP_AGAP009715

4 of 12

Yes

Agam\AgaP_AGAP006731

3 of 12

Yes

Agam\AgaP_AGAP009710

3 of 12

Yes

Agam\AgaP_AGAP009725

3 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

Agam\AgaP_AGAP009713

2 of 12

Yes

Agam\AgaP_AGAP009714

2 of 12

Yes

Agam\AgaP_AGAP009721

2 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CadN. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (13)

CadN2

9 of 13

shg

4 of 13

3 of 13

2 of 13

kug

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

eys

1 of 13

Nrx-IV

1 of 13

SP2353

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

prostate cancer, N-cadherin-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

CadN^NIG.7100R

model of prostate cancer

CEA

(Ito et al., 2014)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CadN

bead aggregation assay, fluorescence microscopy, inferred by author, anti tag coimmunoprecipitation, western blot

(Nishiguchi and Oda, 2021, Cameron et al., 2013, Yonekura et al., 2006)

CadN - Iqsec

bimolecular fluorescence complementation, fluorescence microscopy, two hybrid

(Dottermusch-Heidel et al., 2012)

CadN - Lar

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation

(Kaur et al., 2019, Prakash et al., 2009)

CadN - Src42A

pull down, anti tag western blot

(Pütz, 2019)

CadN - Src64B

pull down, anti tag western blot

(Pütz, 2019)

CadN - arm

anti bait coimmunoprecipitation, western blot

(Loureiro and Peifer, 1998, Iwai et al., 1997)

CadN - α-Cat

anti bait coimmunoprecipitation, western blot

(Iwai et al., 1997)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

CadN

enhanceable

arm

(Mirkovic and Mlodzik, 2006)

CadN

suppressible

arm

(Mirkovic and Mlodzik, 2006)

CadN

enhanceable

Sema1a

(Pecot et al., 2013)

CadN

enhanceable

uzip

(Ding et al., 2011)

CadN

suppressible

uzip

(Ding et al., 2011)

CadN

suppressible

Wnt5

(Ding et al., 2011)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

CycE

suppressible

CadN

(Brumby et al., 2004)

Iqsec

suppressible

CadN

(Dottermusch-Heidel et al., 2012)

suppressible

(Lim et al., 2015)

enhanceable

(Lim et al., 2015)

enhanceable

(Prakash et al., 2009)

Liprin-α

enhanceable

CadN

(Prakash et al., 2009)

Liprin-α

suppressible

CadN

(Prakash et al., 2009)

Rich

enhanceable

CadN

(Tong et al., 2011)

Sema1a

enhanceable

CadN

(Pecot et al., 2013)

seq

suppressible

CadN

(Petrovic and Hummel, 2008)

shg

enhanceable

CadN

(Mirkovic and Mlodzik, 2006)

Wnt5

suppressible

CadN

(Ding et al., 2011)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

61066

DroID - A comprehensive database of gene and protein interactions.

FBgn0015609

MIST (genetic) - An integrated Molecular Interaction Database

35070

MIST (protein-protein) - An integrated Molecular Interaction Database

35070

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-53

Cytogenetic map

36D1-36D3

Sequence location

2L:17,647,053..17,778,340 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

36D1-36D3

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

36D-36D

(determined by in situ hybridisation)

(Uemura et al., 1997)

Experimentally Determined Recombination Data

Location

2-53

(FlyBase, 2016)

2-52.8

(Comeron et al., 2012)

2-53.1

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (151)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Korea

11925

P{VT009094-GAL4}attP2

12587

P{VT009068-GAL4}attP2

12855

P{VT009081-GAL4}attP2

15037

P{VT009076-GAL4}attP2

14596

P{VT009094-lexA}attP2

15968

P{GMR32A05-lexA}JK22C

16292

P{GMR31G11-lexA}attP40

16305

P{GMR31E06-lexA}attP40

7100R-3

7100R-4

v101642

v203999

P{VT009084-GAL4}attP2

More stocks available...

Genomic Clones (59)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (12)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

LD09349

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0015609

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0015609

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Nishiguchi and Oda, 2021, Hsu et al., 2009, Hayashi and Carthew, 2004, Iwai et al., 1997)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

The CadN protein, along with CadN2, acts to restrict ommatidial rotation.

(Mirkovic and Mlodzik, 2006)

ChEST reveals this is a target of Mef2.

(Junion et al., 2005)

Alternative exon 18A encodes for isoforms that are required for R1-R7 targeting.

(Nern et al., 2005)

CadN is required in both individual photoreceptors and their target neurons for photoreceptor axon extension. CadN and CadN2 appear to function redundantly in this process.

(Prakash et al., 2005)

CadN is necessary for shaping cone cell clusters in the retina.

(Hayashi and Carthew, 2004)

CadN plays a crucial role in protoglomerulus formation but is largely dispensible for targeting olfactory receptor neurons to the appropriate region of the antennal lobe.

(Hummel and Zipursky, 2004)

CadN does not have an instructive role in selecting dendritic targets in the projection neurons, but rather is essential for projection neurons to restrict their dendrites to single glomeruli. CadN appears to mediate dendro-dendritic interactions between projection neurons. CadN is also essential for the development of projection neuron axon terminal arbors at two distinct targets; regulating branch stability in the lateral horn and restricting high-order branching in the mushroom body.

(Zhu and Luo, 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

CadN has a role in regulating synaptic target specificity in the visual system.

(Lee et al., 2001)

Mutants exhibit various defects in axon fascicle formation.

(Iwai et al., 1997)

Mutant analysis suggests that processes of axon patterning critically depend on CadN-mediated axon-axon interactions.

(Iwai et al., 1997)

Isolated from a subtractive cDNA library enriched in sequences expressed in the mesoderm.

(Casal and Leptin, 1996)

A CadN cDNA has been cloned and sequenced. CadN is expressed in the early mesoderm.

(Casal and Leptin, 1996)

CadN is recognised by anti-C-NCAD(838-856), probe derived from the chicken N-cadherin.

(Lagunowich et al., 1990)

Relationship to Other Genes

Source for database merge of

Source for merge of: CadN anon- EST:CL32

(Bayraktaroglu, 2000.11.2)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: CadN CG7100

(Zhong, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (43)

Reported As

Symbol Synonym

(Casal and Leptin, 1996)

CG7100

(National Institute of Genetics Fly Stocks, 2022-, Rosa-Ferreira et al., 2015, Lee et al., 2013, Buendia et al., 2012, Neely et al., 2011, Khanna et al., 2010, Ni et al., 2010.12.1, Hsu et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Berger et al., 2008)

CT21941

(Hynes and Zhao, 2000, Hynes and Zhao, 2000)

Cad-N

(Rothenbusch-Fender et al., 2017, Lee et al., 2013)

CadN

(Bischoff et al., 2025, Li et al., 2025, Zhao et al., 2025, Ko et al., 2024, Lowe et al., 2024, Miao et al., 2024, Corthals et al., 2023, Sun et al., 2023, Voutyraki et al., 2023, Adashev et al., 2022, Albright et al., 2022, Beaver et al., 2022, Li et al., 2022, Miozzo et al., 2022, Weichselberger et al., 2022, DeAngelis et al., 2021, Fic et al., 2021, Kohrs et al., 2021, Kvon et al., 2021, Pang et al., 2021, Spierer et al., 2021, Uçkun et al., 2021, Chou et al., 2020, Kurmangaliyev et al., 2020, Liu et al., 2020, Rust et al., 2020, Zhao et al., 2020, Meltzer et al., 2019, Raza et al., 2019, Schumacher, 2019, Burow et al., 2018, Jin et al., 2018, Millard and Pecot, 2018, Peng et al., 2018, Stegeman et al., 2018, Suzuki et al., 2018, Hartenstein et al., 2017, Cannavò et al., 2016, Kidd and Lieber, 2016, Kockel et al., 2016, Aradska et al., 2015, Duff et al., 2015, Maartens and Brown, 2015, Özel et al., 2015, Ashwal-Fluss et al., 2014, Jalvingh et al., 2014, Neville et al., 2014, Yogev and Shen, 2014, Kwon et al., 2013, Mora et al., 2013, Pecot et al., 2013, Buendia et al., 2012, Dottermusch-Heidel et al., 2012, Hazelett et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Jin et al., 2012, Rodriguez et al., 2012, Venables et al., 2012, Ding et al., 2011, Graveley et al., 2011, Hadjieconomou et al., 2011, Hadjieconomou et al., 2011, Neely et al., 2011, Oda and Takeichi, 2011, Venken et al., 2011, Venken et al., 2011, Pereanu et al., 2010, Hsu et al., 2009, Liebl and Featherstone, 2008, Nern et al., 2008, Petrovic and Hummel, 2008, Magalhaes et al., 2007, Yonekura et al., 2007, Biemar et al., 2006, Yonekura et al., 2006, Prakash et al., 2005, Pickeral et al., 2000)

D-cad

(Oda et al., 1993)

(Hynes and Zhao, 2000)

DN-CAD

(Melani et al., 2008)

DN-CAd

(Mukherjee et al., 2012)

DN-Cad

(Schilling et al., 2019, Voog et al., 2014, Robinett et al., 2010, Sheng et al., 2009, Zartman et al., 2009, Hynes and Zhao, 2000, Van Etten, 1999)

DN-cad

(Sun et al., 2020, Kumar et al., 2009, Fung et al., 2008, Tanentzapf et al., 2000)

DN-cadherin

(Kamemura et al., 2021, Muria et al., 2021, Nishiguchi and Oda, 2021)

DNCad

(Cardona et al., 2009, Morante and Desplan, 2008)

DNcad

(Li et al., 2013, Mukherjee et al., 2012, Pereanu et al., 2010, Larsen et al., 2009, Pereanu et al., 2007, Tepass and Harris, 2007)

N-Cad

(Weiner et al., 2025, Isasti-Sanchez et al., 2021, Johnson, 2021, Gheisari et al., 2020, Kaur et al., 2019, Lee and Chen, 2019, Pütz, 2019, Lim et al., 2015, Zhang et al., 2014, Gross et al., 2013, Morillo Prado et al., 2012, Charlton-Perkins et al., 2011, Williamson et al., 2010, Berger et al., 2008, Ackley and Jin, 2004)

N-Cadh

(Prakash et al., 2009)

N-Cadherin

(Bischoff and Bogdan, 2021, Weiglein et al., 2021)

N-cad

(Eschbach et al., 2020, Sun et al., 2020, Ito et al., 2014, Schäfer et al., 2014, Hakeda-Suzuki et al., 2011, Prakash et al., 2009, Morey et al., 2005, Hummel and Zipursky, 2004)

N-cadherin

(Mallart et al., 2022, Bao, 2014, Muha and Müller, 2013, Giachello et al., 2012, Muñoz-Soriano et al., 2012, Nose, 2012)

NCAD

(Casper et al., 2011)

NCad

(Agi et al., 2024, Malin and Desplan, 2021, Vidaurre and Chen, 2021, Venugopal et al., 2020, Oliva et al., 2014, Schäfer et al., 2014, Hasegawa et al., 2011, Sweeney et al., 2011, Potter et al., 2010, Tajiri et al., 2007, Hsu et al., 2006)

S(DmcycE^JP)2.12

(Brumby et al., 2004)

anon-EST:CL32

cad1

(Mirkovic and Mlodzik, 2006)

cadN

(Sutton et al., 2024, Harrison et al., 2021, Chen et al., 2015, Mirkovic and Mlodzik, 2006)

l(2)36Da

(Uemura, 1997.3.28)

l(2)Bld

(Mahajan-Miklos and Cooley, 1994, Steward and Nusslein-Volhard, 1986, Woodruff and Ashburner, 1979, Wright et al., 1976)

n-cad

(Seppa et al., 2008)

ncad

(Gontang et al., 2011, Lee et al., 2001)

Name Synonyms

Cadherin-N

(Jin et al., 2018, Cannavò et al., 2016, Rembold et al., 2014, Venables et al., 2012, Choo et al., 2011, Graveley et al., 2011, Zartman et al., 2009, Petrovic and Hummel, 2008, Terry et al., 2006, Burnette et al., 2005, Cho et al., 2005, Oda et al., 1996)

CadherinN

(Kuzin et al., 2005)

DN cadherin

(Younossi-Hartenstein et al., 2006)

DN-CADHERIN

(Erclik et al., 2008)

DN-Cadherin

(Sekine et al., 2013, Robinett et al., 2010, Sheng et al., 2009, Spindler et al., 2009, Morante and Desplan, 2008, Hayashi and Carthew, 2004, Iwai et al., 2002, Patel and Van Vactor, 2002, Newsome et al., 1999)

DN-cadherin, N-cadherin

(Gross et al., 2013)

DN-cadherin1

(Durupt et al., 2007)

Drosophila neuronal cadherin

(Iwai et al., 1997)

N-CADHERIN

(Yang et al., 2012)

N-cadherin

(Bischoff et al., 2025, Long et al., 2025, Truman and Riddiford, 2023, Roberto and Emery, 2022, Ko and Martin, 2020, Weidner et al., 2020, Hamp et al., 2016, Okumura et al., 2016, Bao, 2014, Cameron et al., 2013, Li et al., 2013, Schwabe et al., 2013, Bulgakova et al., 2012, Hong et al., 2012, Gemp et al., 2011, Gontang et al., 2011, Hadjieconomou et al., 2011, Hakeda-Suzuki et al., 2011, Hasegawa et al., 2011, Shimizu et al., 2011, Spindler and Hartenstein, 2011, Chou et al., 2010, Khanna et al., 2010, Khanna et al., 2010, Riddiford et al., 2010, Akten et al., 2009, Dasgupta et al., 2009, Grillo-Hill and Wolff, 2009, Hong et al., 2009, Issigonis et al., 2009, Kurshan et al., 2009, Larsen et al., 2009, Prakash et al., 2009, Hilgenfeldt et al., 2008, Holbrook and Herman, 2008, Zhu et al., 2008, Bazigou et al., 2007, Käfer et al., 2007, Lecuit and Le Goff, 2007, Yonekura et al., 2007, Axelrod, 2006, Choe et al., 2006, Larsen et al., 2006, Siddall et al., 2006, Yonekura et al., 2006, Leptin, 2005, Mehta et al., 2005, Morey et al., 2005, Prakash and Clandinin, 2005, Prakash et al., 2005, Hallem and Carlson, 2004, Hayashi and Carthew, 2004, Jefferis et al., 2004, Zhu and Luo, 2004, Liu and Cadigan, 2003, Shook and Keller, 2003, Younossi-Hartenstein et al., 2003, Renfranz and Beckerle, 2002, Chase, 2001, Chiba, 2001, Wilson and Leptin, 2000, Leptin, 1999, Lagunowich et al., 1990)

NCadherin

(Mora et al., 2013)

lethal(2)36Da

n-cadherin

(Seppa et al., 2008)

nCadherin

(Kiral et al., 2020)

Secondary FlyBase IDs

FBgn0002007
FBgn0019859

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 93 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35070

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

O15943

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

O15943

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

O15943

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35070/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015609

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015609

FlyMine - An integrated database for Drosophila genomics

FBgn0015609

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7100

MARRVEL_MODEL - MARRVEL (model organism gene)

35070

PDB - An information portal to biological macromolecular structures

Linkouts

BioGRID - A database of protein and genetic interactions.

61066

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0015609

DroID - A comprehensive database of gene and protein interactions.

FBgn0015609

DRSC - Results frm RNAi screens

FBgn0015609

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015609

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0015609

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7100

Flygut - An atlas of the Drosophila adult midgut

FBgn0015609

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC033193

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

35070

MIST (protein-protein) - An integrated Molecular Interaction Database

35070

References (415)

The following external sites may use different assemblies or annotations than FlyBase.

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