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Mehta, S.Q., Hiesinger, P.R., Beronja, S., Zhai, R.G., Schulze, K.L., Verstreken, P., Cao, Y., Zhou, Y., Tepass, U., Crair, M.C., Bellen, H.J. (2005). Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components.  Neuron 46(2): 219--232.
FlyBase ID
FBrf0188181
Publication Type
Research paper
Abstract

The exocyst is a complex of proteins originally identified in yeast that has been implicated in polarized secretion. Components of the exocyst have been implicated in neurite outgrowth, cell polarity, and cell viability. We have isolated an exocyst component, sec15, in a screen for genes required for synaptic specificity. Loss of sec15 causes a targeting defect of photoreceptors that coincides with mislocalization of specific cell adhesion and signaling molecules. Additionally, sec15 mutant neurons fail to localize other exocyst members like Sec5 and Sec8, but not Sec6, to neuronal terminals. However, loss of sec15 does not cause cell lethality in contrast to loss of sec5 or sec6. Our data suggest a role of Sec15 in an exocyst-like subcomplex for the targeting and subcellular distribution of specific proteins. The data also show that functions of other exocyst components persist in the absence of sec15, suggesting that different exocyst components have separable functions.

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Personal communication to FlyBase

Correction of sec15[1] molecular data and sec15[+t5] rescue allele primers.
Mehta, 2013.11.4, Correction of sec15[1] molecular data and sec15[+t5] rescue allele primers. [FBrf0223205]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference
    Aberrations (2)
    Alleles (10)
    Genes (15)
    Natural transposons (1)
    Transgenic Constructs (5)