FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Sec5
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General Information
Symbol
Dmel\Sec5
Species
D. melanogaster
Name
Secretory 5
Annotation Symbol
CG8843
Feature Type
protein_coding_gene
FlyBase ID
FBgn0266670
Gene Model Status
Current
Stock Availability
13 publicly available
Gene Summary
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (UniProt, Q9VQQ9)
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
23F3-23F3
Sequence location
Recombination map
2-10
RefSeq locus
NT_033779 REGION:3457302..3460367
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (32 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables small GTPase binding
inferred from physical interaction with FLYBASE:Rab11; FB:FBgn0015790
(Beronja et al., 2005)
inferred from physical interaction with FLYBASE:Rab30; FB:FBgn0031882
(Gillingham et al., 2014)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (21 terms)
Terms Based on Experimental Evidence (17 terms)
CV Term
Evidence
References
involved_in anterograde axonal protein transport
inferred from mutant phenotype
(Murthy et al., 2003)
inferred from direct assay
(Murthy et al., 2003)
involved_in border follicle cell migration
inferred from mutant phenotype
(Assaker et al., 2010)
involved_in branch fusion, open tracheal system
inferred from mutant phenotype
(Kakihara et al., 2008, Jiang et al., 2007)
involved_in cellularization
inferred from mutant phenotype
(Murthy et al., 2010)
involved_in endocytic recycling
inferred from mutant phenotype
(Langevin et al., 2005, Sommer et al., 2005)
involved_in Golgi to plasma membrane protein transport
inferred from mutant phenotype
(Murthy et al., 2005)
involved_in Golgi to plasma membrane transport
inferred from mutant phenotype
(Murthy et al., 2003)
involved_in innate immune response
inferred from direct assay
(Chien et al., 2006)
involved_in oocyte development
inferred from mutant phenotype
(Sommer et al., 2005)
involved_in positive regulation of Golgi vesicle fusion to target membrane
inferred from mutant phenotype
(Murthy et al., 2003)
involved_in protein localization to adherens junction
inferred from mutant phenotype
(Langevin et al., 2005)
involved_in protein localization to cell cortex
inferred from mutant phenotype
(Langevin et al., 2005)
involved_in protein localization to membrane
inferred from direct assay
(Mavor et al., 2016)
involved_in protein localization to plasma membrane
inferred from mutant phenotype
(Langevin et al., 2005)
involved_in regulation of synapse maturation
inferred from mutant phenotype
(Murthy et al., 2003)
inferred from direct assay
(Murthy et al., 2003)
involved_in transcytosis
inferred from mutant phenotype
(Langevin et al., 2005)
involved_in vesicle-mediated transport
inferred from mutant phenotype
(Jones et al., 2014)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
involved_in exocytosis
inferred from biological aspect of ancestor with PANTHER:PTN000315823
(GO Reference Genome Project, 2011-)
involved_in Golgi to plasma membrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000315823
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR029175
(InterPro Project Members, 2004-)
involved_in neurotransmitter secretion
non-traceable author statement
(Lloyd et al., 2000)
involved_in synaptic vesicle docking
non-traceable author statement
(Lloyd et al., 2000)
involved_in synaptic vesicle targeting
non-traceable author statement
(Lloyd et al., 2000)
involved_in vesicle-mediated transport
inferred from sequence or structural similarity
(Littleton, 2000)
Cellular Component (10 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
located_in annulate lamellae
inferred from direct assay
(Jiang et al., 2007)
located_in cell cortex
inferred from direct assay
(Langevin et al., 2005)
located_in clathrin-coated vesicle
inferred from direct assay
(Sommer et al., 2005)
located_in cytoplasm
inferred from direct assay
(Murthy et al., 2010, Beronja et al., 2005, Sommer et al., 2005)
part_of exocyst
inferred from direct assay
(Beronja et al., 2005, Langevin et al., 2005, Sommer et al., 2005)
is_active_in neuromuscular junction
inferred from mutant phenotype
(Murthy et al., 2003)
inferred from direct assay
(Murthy et al., 2003)
located_in plasma membrane
inferred from direct assay
(Beronja et al., 2005, Murthy et al., 2005, Sommer et al., 2005)
located_in recycling endosome
inferred from direct assay
(Langevin et al., 2005)
located_in rhabdomere
inferred from direct assay
(Beronja et al., 2005)
part_of subapical complex
inferred from direct assay
(Murthy et al., 2010)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of exocyst
inferred from electronic annotation with InterPro:IPR029175
(InterPro Project Members, 2004-)
non-traceable author statement
(Lloyd et al., 2000)
inferred from biological aspect of ancestor with PANTHER:PTN000315823
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity
(Littleton, 2000)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the SEC5 family. (Q9VQQ9)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
EXOCYST -
The exocyst complex is composed of eight proteins. It is involved tethering secretory vesicles to the plasma membrane and may regulate other aspects of intracellular trafficking such as SNARE assembly, cytokinesis and endocytic recycling. The exocyst complex is a member of the Complex Associated with Tethering Containing Helical Rods (CATCHR) family. (Adapted from FBrf0219543).
Protein Function (UniProtKB)
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
(UniProt, Q9VQQ9)
Summary (Interactive Fly)

a member of the exocyst complex - promotes vesicular trafficking involved in cell growth and membrane protein insertion - required for membrane traffic and polarity in the oocyte - mediates embryo cellularization

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Sec5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VQQ9)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.52

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Sec5-RA
FBtr0077519
NM_134936
2885
894
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Sec5-PA
FBpp0077208
100.7
894
5.62
Q9VQQ9
NP_608780
AAF51106
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

The exocyst complex is composed of Sec3/Exoc1, Sec5/Exoc2, Sec6/Exoc3, Sec8/Exoc4, Sec10/Exoc5, Sec15/Exoc6, Exo70/Exoc7 and Exo84/Exoc8.

(UniProt, Q9VQQ9)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sec5 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.71

Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
first instar larval stage -- third instar larval stage
neuropil of larval ventral nerve cord
(Murthy et al., 2005)
oogenesis stage S3 -- S4
nurse cell
(Murthy et al., 2005)
oocyte
(Murthy et al., 2005)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data

Sec5 protein is heavily concentrated in the neuropil of the larval ventral nerve cord. In the developing egg chamber, Sec5 protein concentrates in membanes, and is enriched at the boundary between the oocyte and the posterior follicle cells.

(Murthy et al., 2005)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in annulate lamellae
inferred from direct assay
(Jiang et al., 2007)
located_in cell cortex
inferred from direct assay
(Langevin et al., 2005)
located_in clathrin-coated vesicle
inferred from direct assay
(Sommer et al., 2005)
located_in cytoplasm
inferred from direct assay
(Murthy et al., 2010, Beronja et al., 2005, Sommer et al., 2005)
part_of exocyst
inferred from direct assay
(Beronja et al., 2005, Langevin et al., 2005, Sommer et al., 2005)
is_active_in neuromuscular junction
inferred from mutant phenotype
(Murthy et al., 2003)
inferred from direct assay
(Murthy et al., 2003)
located_in plasma membrane
inferred from direct assay
(Beronja et al., 2005, Murthy et al., 2005, Sommer et al., 2005)
located_in recycling endosome
inferred from direct assay
(Langevin et al., 2005)
located_in rhabdomere
inferred from direct assay
(Beronja et al., 2005)
part_of subapical complex
inferred from direct assay
(Murthy et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Sec5 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Sec5
Transgenic constructs containing regulatory region of Sec5
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(2L)Exel7016
(Ryder, 2004.4.26)
Df(2L)tim-02
(Murthy et al., 2003)
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
cell lethal | recessive | somatic clone
cell lethal | somatic clone | heat sensitive
cell lethal | somatic clone | third instar larval stage | heat sensitive, with Scer\GAL4en-e16E
lethal, with Scer\GAL4grh.D4
lethal | recessive
lethal - all die before end of larval stage (with Df(2L)tim-02)
lethal - all die before end of larval stage | recessive
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female fertile | germline clone
female sterile | germline clone
Other Phenotypes
Allele
abnormal developmental rate | larval stage, with Scer\GAL4phtm.PO
abnormal neuroanatomy | larval stage, with Scer\GAL4elav.PU
abnormal neuroanatomy | somatic clone | third instar larval stage
abnormal size | cell non-autonomous | heat sensitive, with Scer\GAL4en-e16E
decreased body size | larval stage, with Scer\GAL4grh.D4
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
some die during larval stage, with Scer\GAL4phtm.PO
some die during larval stage (with Df(2L)tim-02)
some die during larval stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
visible | dominant
visible | larval stage, with Scer\GAL4grh.D4
visible | recessive
visible | recessive | somatic clone
visible | somatic clone
visible | somatic clone | heat sensitive
Phenotype manifest in
Allele
border follicle cell, with Scer\GAL4c306
bouton
centrosome | somatic clone
clathrin-coated vesicle & oocyte | germ-line clone
coated pit & oocyte | germ-line clone
cytoplasmic vesicle & oocyte | germ-line clone
dorsal appendage | germline clone
dorsal tracheal branch primordium
egg | germline clone
embryo | embryonic stage 5 | germline clone | non-rescuable maternal effect
embryonic/larval dorsal tracheal branch 1
embryonic/larval dorsal tracheal branch 2
embryonic/larval dorsal tracheal branch 3
embryonic/larval dorsal tracheal branch 4
embryonic/larval dorsal tracheal branch 5
embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4elav.PU
embryonic/larval posterior spiracle | larval stage, with Scer\GAL4grh.D4
embryonic/larval tracheal dorsal trunk | first instar larval stage, with Scer\GAL4grh.D4
external sensory organ precursor cell I | somatic clone
eye | somatic clone
eye | somatic clone | heat sensitive
eye disc | somatic clone | third instar larval stage | heat sensitive, with Scer\GAL4en-e16E
eye photoreceptor cell | somatic clone | heat sensitive
female germline cell | germline clone
follicle cell | germline clone
furrow canal | germline clone | non-rescuable maternal effect
Golgi stack | germline clone
larval multidendritic class IV neuron | somatic clone | third instar larval stage
mesonotum | P-stage | somatic clone
muscle cell of A1-7 ventral longitudinal muscle 3
neurite
NMJ bouton | increased number | larval stage, with Scer\GAL4elav.PU
nurse cell & actin filament | germ-line clone
nurse cell & plasma membrane | germ-line clone
nurse cell ring canal | germline clone
oocyte | germline clone
oocyte nucleus | germline clone
polar follicle cell | germline clone
presynaptic active zone | larval stage, with Scer\GAL4elav.PU
recycling endosome | somatic clone
ring canal | germline clone
wing disc | somatic clone | third instar larval stage | heat sensitive, with Scer\GAL4en-e16E
yolk | germline clone
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\EXOC2
14 of 14
Yes
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Exoc2
13 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Exoc2
13 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\exoc2
8 of 13
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\exoc2
14 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\sec-5
14 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP001733
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\SEC5B
11 of 13
Yes
Yes
Atha\SEC5A
10 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\SEC5
6 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPCC622.10c
2 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Sec5. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Sec5E10
    exacerbates  muscular dystrophy
    modeled by DgO86
    (Yatsenko et al., 2021)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    EXOC2; exocyst complex component 2
    14 of 14
    615329
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Sec5
      enhanceable
      dnd
      (Kakihara et al., 2008)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      dnd
      enhanceable
      Sec5
      (Kakihara et al., 2008)
      Exo84
      enhanceable
      Sec5
      (Blankenship et al., 2007)
      Rala
      enhanceable
      Sec5
      (Balakireva et al., 2006)
      External Data
      Subunit Structure (UniProtKB)
      The exocyst complex is composed of Sec3/Exoc1, Sec5/Exoc2, Sec6/Exoc3, Sec8/Exoc4, Sec10/Exoc5, Sec15/Exoc6, Exo70/Exoc7 and Exo84/Exoc8.
      (UniProt, Q9VQQ9 )
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2L
      Recombination map
      2-10
      Cytogenetic map
      23F3-23F3
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      23F3-23F3
      Limits computationally determined from genome sequence between P{lacW}Madk00237 and P{lacW}Pdswk10101
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.
      (Lloyd et al., 2000)
      23F-24A
      (Lloyd et al., 2000)
      Experimentally Determined Recombination Data
      Location

      2-10

      (FlyBase, 2016)

      2-8.3

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (13)
      Genomic Clones (9)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (13)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            S2 cells treated with dsRNA directed against sec5 show normal binding and internalization of E.coli and normal binding but significantly decreased internalization of S.aureus in a phagocytosis assay.

            (Stuart et al., 2007)

            The sec5 product negatively regulates dac expression in the embryonic head.

            (Anderson et al., 2006)

            sec5 heterozygotes are viable but exhibit a reduced immune response to fungal invasion.

            (Chien et al., 2006)

            In sec5 mutant epithelial cells, lateral shg protein is not recycled to the adherens junctions but instead accumulates in recycling endosomes.

            (Langevin et al., 2005)

            dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.

            (Echard et al., 2004)

            dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

            (Kiger et al., 2003)
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: Sec5 sec5

            (FlyBase, 1992-)
            Additional comments
            Nomenclature History
            Source for database identify of

            Source for identity of: Sec5 sec5

            (FlyBase, 2009-)

            Source for identity of: sec5 CG8843

            (Verstreken and Bellen, 2000.9.4)
            Nomenclature comments
            Etymology

            Named "Sec5" after the S. cerevisiae ortholog.

            (FlyBase, 2009-)
            Synonyms and Secondary IDs (11)
            Reported As
            Symbol Synonym
            CG8843
            (National Institute of Genetics Fly Stocks, 2022-, Laffafian and Tepass, 2019, Hosono et al., 2015, Cammarato et al., 2011, Ni et al., 2010.12.1, Perkins et al., 2009, Gandhi et al., 2007, Stuart et al., 2007)
            SEC5
            (Mirey et al., 2003)
            Sec-5
            (Kirby et al., 2004)
            Sec5
            (Torabi-Marashi et al., 2025, Dennis et al., 2024, Jiang, 2024, Lee et al., 2024, Sanal et al., 2023, Sebastian et al., 2022, Swope et al., 2022, van de Leemput et al., 2022, Wang et al., 2022, Allen et al., 2021, Camelo and Luschnig, 2021, Chan et al., 2021, Evans et al., 2021, Ricolo et al., 2021, Yatsenko et al., 2021, Wen et al., 2020, Chaudhary and Boutros, 2019, Laffafian and Tepass, 2019, Lopez-Gonzalez et al., 2019, Mao et al., 2019, Schroeder et al., 2019, Chlamydas et al., 2016, Fear et al., 2016, Lee and Schwarz, 2016, Roman-Fernandez and Bryant, 2016, Giansanti et al., 2015, Ng and Jackson, 2015, Yamanaka et al., 2015, Chabu and Xu, 2014, Gillingham et al., 2014, Jones et al., 2014, Tan et al., 2014, Yashiro et al., 2014, Wan et al., 2013, Gault et al., 2012, Hallacli et al., 2012, Heider and Munson, 2012, Michel et al., 2011, Otani et al., 2011, Raja et al., 2010, Lee and Cooley, 2007, Chien et al., 2006, Shimada et al., 2006, Beronja et al., 2005, Sommer et al., 2005, Sommer et al., 2005, Littleton, 2000)
            Sec5p
            (Littleton, 2000)
            dsec5
            (Lloyd et al., 2000)
            pdig4
            (Geisbrecht et al., 2013)
            sec5
            (Maruzs et al., 2023, Aguilar-Aragon et al., 2020, Liu et al., 2019, Pinheiro et al., 2017, Calero-Cuenca et al., 2016, Sarov et al., 2016, Tracy et al., 2016, Chang et al., 2015, Tsai et al., 2014, Geisbrecht et al., 2013, Jauffred et al., 2013, Teodoro et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Lesch and Page, 2012, Gerhold et al., 2011, Halbsgut et al., 2011, Seong et al., 2011, Andersen et al., 2010, Assaker et al., 2010, Murthy et al., 2010, Windler and Bilder, 2010, FlyBase, 2009-, Kelkar and Dobberstein, 2009, Kakihara et al., 2008, Leibfried et al., 2008, Blankenship et al., 2007, Coutelis and Ephrussi, 2007, Jiang et al., 2007, Stuart et al., 2007, Anderson et al., 2006, Balakireva et al., 2006, van IJzendoorn, 2006, Classen et al., 2005, Langevin et al., 2005, Mehta et al., 2005, Mehta et al., 2005, Murthy et al., 2005)
            Name Synonyms
            Sec5 ortholog
            Secretory 5
            par-1 dominant interacting gene 4
            (Geisbrecht et al., 2013)
            sec5
            (Cammarato et al., 2011, Gerhold et al., 2011)
            Secondary FlyBase IDs
            • FBgn0266610
            • FBgn0031537
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 34 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            References (144)