FB2026_02 , released June 18, 2026
Allele: Dmel\Sec151
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General Information
Symbol
Dmel\Sec151
Species
D. melanogaster
Name
FlyBase ID
FBal0197840
Feature type
allele
Associated gene
Dmel\Sec15
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Mehta et al., 2005)
Progenitor genotype
Cytology
Description

Revision of amino acid replacement data reported in FBrf0188181.

(Mehta, 2013.11.4)

Amino acid replacement: K137term.

(Mehta, 2013.11.4)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:21,107,421..21,107,421 [-]
Nucleotide change:

A21107421T

Amino acid change:

K137term | Sec15-PA

Reported amino acid change:

K137term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Mehta, 2013.11.4)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  cancer
      modeled by Ras85DV12.UAS
      (Chabu and Xu, 2014)
      exacerbates  muscular dystrophy
      modeled by DgO86
      (Yatsenko et al., 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      adult optic lobe | somatic clone

      (Mehta et al., 2005)

      axon & photoreceptor cell R7 | somatic clone

      (Mehta et al., 2005)

      axon & photoreceptor cell R8 | somatic clone

      (Mehta et al., 2005)

      medulla | somatic clone

      (Mehta et al., 2005)

      nerve terminal & optic cartridge | somatic clone

      (Mehta et al., 2005)
      Detailed Description
      Statement
      Reference

      Sec151 mutant clones do not affect cell proliferation in eye-antenna imaginal discs and the size of Sec151 mutant clones is comparable to wild type. Sec151 mutant cells persist into the adult eye.

      (Chabu and Xu, 2014)

      Neuronal differentiation is normal in sec151 homozygous clones in the developing eye.

      (Mehta et al., 2005)

      Flies whose eyes are homozygous for sec151 (due to somatic clones induced using Scer\FRT and Scer\FLP1ey.PN) exhibit reduce phototaxis in response to red and blue light. Electro-retinograms of these animals show normal depolarization in response to light but an absence of on and off transients. Projections from photoreceptors are aberrant in the eyes of these flies: there is not regular array of terminals in the medulla and R7 and R8 target layering is highly aberrant. Neuropils in the optic lobes of these flies are abnormally shaped, but their size and arrangement are normal. On a gross level, long range pathfinding, extension and targeting of R7 axons appears to be normal. However R7 terminals fail to establish normal, local wiring patterns within their target neuropils.

      Most wild-type lamina cartridges have 6 photoreceptor terminals per cartridge, with a few showing 5, very occasionally, 7. Flies whose eyes are homozygous for sec151 (due to somatic clones induced using Scer\FRT and Scer\FLP1ey.PN), numbers of photoreceptor terminals per cartridge range from 2-8 and are relatively evenly distributed throughout this range (4-5 is most common, 2 less). However, these terminals form morphologically normal synapses in normal numbers per terminal. When somatic clones of sec151 homozygous cells are instead induced using Scer\FLP1ey.3.5.hs, mutant optic lobes still exhibit neuronal targeting defects but the distribution of terminal numbers per cartridge is less broad and on/off transients in electro-retinograms are reduced rather than eliminated.

      (Mehta et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Sec151 is a suppressor of eye disc | somatic clone phenotype of Ras85DV12.UAS, Scer\GAL4Act.PU

      (Chabu and Xu, 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Sec151/+;Arfip71/+ third instar larvae do not show a reduction in bouton number at the neuromuscular junction, compared to Sec151/+ heterozygotes.

      (Chang et al., 2015)

      Sec151 dramatically suppresses the overgrowth phenotype and pupal lethality seen in eye-antennal disc clones expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU. The increased secretion (dye clearance) seen in cells expressing Ras85DV12.Scer\UAS is also suppressed by Sec151. Cell death is no longer detected in the wild type cells surrounding the clones.

      Expression of bskDN.Scer\UAS suppresses the increased cell death seen in eye-antennal disc clones expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU in a Sec151 mutant background. Tumor growth is not restored to that seen in clones expressing Ras85DV12.Scer\UAS alone.

      (Chabu and Xu, 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Sec151 is rescued by Sec15UAS.Tag:HA

      (Mehta et al., 2005)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (14)