FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sec153
Open Close
General Information
Symbol
Dmel\Sec153
Species
D. melanogaster
Name
FlyBase ID
FBal0212243
Feature type
allele
Associated gene
Dmel\Sec15
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Jafar-Nejad et al., 2005)
Mutagen
ethyl methanesulfonate
(Jafar-Nejad et al., 2005)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q563term.

(Jafar-Nejad et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:21,106,079..21,106,079 [-]
Nucleotide change:

C21106079T

Amino acid change:

Q563term | Sec15-PA

Reported amino acid change:

Q563term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Jafar-Nejad et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      eo neuron & mesothoracic tergum & pupa | somatic clone | supernumerary

      (Jafar-Nejad et al., 2005)

      macrochaeta & mesothoracic tergum | somatic clone

      (Jafar-Nejad et al., 2005)

      thecogen cell & mesothoracic tergum & pupa | somatic clone

      (Jafar-Nejad et al., 2005)

      tormogen cell & mesothoracic tergum & pupa | somatic clone

      (Jafar-Nejad et al., 2005)
      Detailed Description
      Statement
      Reference

      Somatic clones of sec153 homozygous cells in the notum exhibit severe bristle loss. Analysis of developing notal bristles in these clones at 24-26 hours after puparium formation shows many have 4-6 neurons (as opposed to the normal 1), 0-2 sheath cells and, in most cases, no socket cell. These phenotypes are indicative of a PIIa to PIIb transformation. The resulting adult nota have patches which completely lack bristles.

      Apical-basal polarity in sensory organ precursor cells is not disrupted in sec153/sec153 somatic clones.

      (Jafar-Nejad et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Sec153 has macrochaeta & mesothoracic tergum | somatic clone phenotype, suppressible by NECN.UAS/Scer\GAL4sca-109-68

      (Jafar-Nejad et al., 2005)
      NOT Suppressor of
      Statement
      Reference

      Sec153 is a non-suppressor of macrochaeta & mesothoracic tergum | somatic clone phenotype of spdoG104

      (Jafar-Nejad et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Bristle loss in somatic clones of sec153 homozygous cells in the notum is suppressed by NECN.Scer\UAS; Scer\GAL4sca-109-68. Instead they have the bristle phenotype seen in NECN.Scer\UAS; Scer\GAL4sca-109-68 animals: two sockets and no shaft.

      (Jafar-Nejad et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Sec153
      sec15-3
      (Windler and Bilder, 2010)
      sec153
      (Giagtzoglou et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)