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Ding, Z.Y., Wang, Y.H., Luo, Z.K., Lee, H.F., Hwang, J., Chien, C.T., Huang, M.L. (2011). Glial cell adhesive molecule unzipped mediates axon guidance in Drosophila.  Dev. Dyn. 240(1): 122--134.
FlyBase ID
FBrf0212620
Publication Type
Research paper
Abstract

Axon guidance needs help from the glial cell system during embryogenesis. In the Drosophila embryonic central nervous system (CNS), longitudinal glia (LG) have been implicated in axon guidance but the mechanism remains unclear. We identified the protein encoded by the Drosophila gene unzipped (uzip) as a novel cell adhesion molecule (CAM). Uzip expressed in Drosophila S2 cells triggered cell aggregation through homophilic binding. In the embryonic CNS, Uzip was mainly produced by the LG but was also located at axons, which is consistent with the secretion of Uzip expressed in cultured cells. Although uzip mutants displayed no axonal defect, loss of uzip enhanced the axonal defects in the mutant of N-cadherin (CadN) and the Wnt gene family member wnt5. Overexpression of uzip could rescue the phenotype in the CadNuzip(D43) mutant. Thus, Uzip is a novel CAM from the LG regulating axon guidance.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Dyn.
    Title
    Developmental Dynamics
    Publication Year
    1992-
    ISBN/ISSN
    1058-8388
    Data From Reference
    Aberrations (1)
    Alleles (17)
    Genes (10)
    Cell Lines (1)
    Natural transposons (1)
    Insertions (6)
    Experimental Tools (3)
    Transgenic Constructs (7)