FlyBase Allele Report: Dmel\uzip[RNAi.Sym.UAS]

General Information

Symbol

Dmel\uzip^RNAi.Sym.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0249055

Feature type

allele

Associated gene

Dmel\uzip

Associated Insertion(s)

Carried in Construct

P{Sym-UAS-uzip}

Key Links

Transgenic product class

RNAi_reagent

(Ding et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ding et al., 2011)

Mutagen

in vitro construct

(Ding et al., 2011)

Progenitor genotype

Carried in construct

P{Sym-UAS-uzip}

Cytology

Description

Sense-antisense transcription of full-length uzip (driven by two convergent arrays of UAS sequence) results in double stranded RNA (dsRNA) expression.

(Ding et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

uzip

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

uzip^RNAi.Sym.UAS/Scer\GAL4^repo is an enhancer of abnormal neuroanatomy phenotype of CadN^M19

(Ding et al., 2011)

Scer\GAL4^elav-C155/uzip^RNAi.Sym.UAS is an enhancer of abnormal neuroanatomy phenotype of CadN^M19

(Ding et al., 2011)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^elav-C155/uzip^RNAi.Sym.UAS is an enhancer of larval anterior commissure phenotype of CadN^M19

(Ding et al., 2011)

Scer\GAL4^elav-C155/uzip^RNAi.Sym.UAS is an enhancer of presumptive embryonic/larval central nervous system phenotype of CadN^M19

(Ding et al., 2011)

uzip^RNAi.Sym.UAS/Scer\GAL4^repo is an enhancer of MP1 tract phenotype of CadN^M19

(Ding et al., 2011)

Scer\GAL4^elav-C155/uzip^RNAi.Sym.UAS is an enhancer of larval MP1 neuron phenotype of CadN^M19

(Ding et al., 2011)

Scer\GAL4^elav-C155/uzip^RNAi.Sym.UAS is an enhancer of dMP2 neuron phenotype of CadN^M19

(Ding et al., 2011)

Scer\GAL4^elav-C155/uzip^RNAi.Sym.UAS is an enhancer of MP1 tract phenotype of CadN^M19

(Ding et al., 2011)

uzip^RNAi.Sym.UAS/Scer\GAL4^repo is an enhancer of larval anterior commissure phenotype of CadN^M19

(Ding et al., 2011)

uzip^RNAi.Sym.UAS/Scer\GAL4^repo is an enhancer of presumptive embryonic/larval central nervous system phenotype of CadN^M19

(Ding et al., 2011)

uzip^RNAi.Sym.UAS/Scer\GAL4^repo is an enhancer of larval MP1 neuron phenotype of CadN^M19

(Ding et al., 2011)

uzip^RNAi.Sym.UAS/Scer\GAL4^repo is an enhancer of dMP2 neuron phenotype of CadN^M19

(Ding et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Neuronal knockdown of uzip through expression of uzip^{dsRNA.Sym.Scer\UAS} under the control of Scer\GAL4^elav-C155 slightly (but not significantly) increases axonal defects in CadN^M19 mutants.

Glial knockdown through expression of uzip^{dsRNA.Sym.Scer\UAS} under the control of Scer\GAL4^repo, increases the axonal defects found in CadN^M19 mutants.

Neuronal knockdown of uzip through expression of uzip^Sym.Scer\UAS and uzip^{a.Sym.Scer\UAS} under the control of Scer\GAL4^elav-C155 slightly (but not significantly) increases axonal defects in CadN^M19 mutants. Glial knockdown through expression of uzip^Sym.Scer\UAS and uzip^{a.Sym.Scer\UAS} under the control of Scer\GAL4^repo, increases the axonal defects found in CadN^M19 mutants.

(Ding et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

uzip^RNAi.Sym.UAS

uzip^Sym.Scer\UAS

uzip^{dsRNA.Sym.Scer\UAS}

uzip^{dsRNA.Sym.UAS}

Name Synonyms

Secondary FlyBase IDs

FBal0249056

References (2)

Report Sections

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