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FB2026_01
,
released March 12, 2026
Dliprin-α, Liprin, Dliprin, oos
scaffolding protein that physically interacts with LAR and is essential for R7 axon targeting
Please see the JBrowse view of Dmel\Liprin-α for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.45
Stop-codon suppression (UGA) postulated; FBrf0216884.
Gene model reviewed during 5.44
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
The group(s) of polypeptides indicated below share identical sequence to each other.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Liprin-α using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Liprin-α transcripts are abundant in embryos from the cellular blastoderm stage through to hatching. Highest transcript levels are seen in the developing peripheral and central nervous systems. Late in embryogenesis, no Liprin-α transcripts are observed outside of the nervous system. Expression is also observed in the larval body wall muscle and CNS.
In late embryos, the highest levels of Liprin-α protein are observed in the neuropil of the ventral nerve cord. It is present in both longitudinal and commissural neuropil in stage 16 but becomes restricted to longitudinal neuropil in stage 17 embryos and first instar larvae. In larvae, Liprin-α is found at neuromuscular junctions. It is present in synapses and not along axons. It is abundant both on presynaptic and postsynaptic sides of the neuromuscular junction. It is also observed in the larval CNS.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Liprin-α in JBrowse2-22
2-21.6
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Liprin-α activity is required cell-autonomously in R cell axons, acting before synapse formation, to allow axons to extend to their targets in the lamina.
Mutations in Liprin-α prevent R7 photoreceptor axons from reaching their normal target layer. R7 photoreceptors lacking Liprin-α differentiate correctly, as monitored by their rhabdomere position and the expression of their characteristic opsins, R3 and R4. However, R7 axons stop precociously in the R8 terminal layer. Differentiation of R1 to R6 and their termination in the lamina are not affected in Liprin-α mutants.
Identification: Binding partner to the cytoplasmic domain of Lar in a yeast two hybrid screen.
Source for merge of: Liprin-α oos CG11199
